The Effect of the Thickness of the Cortical Bone on Bone Formation by Osteoperiosteal Grafts:<i>A Comparative Study Employing Routine Histological Stains and Triple Fluorochrome Labelling</i>

Poussa, Mikko; Rubak, Jens M.; Ritsilä, Veijo

doi:10.3109/17453678008990765

Cited by 6 publications

(3 citation statements)

References 11 publications

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“…This conception was confirmed in studies with periosteal grafts in muscle tissue (Poussa 1980). However, other factors are also essential for formation of new bone, but these are less known and thought to be humorally mediated or based on close interactions between the graft and the recipient bed cells (Urist et al 1967, Saxen 1972.…”

supporting

confidence: 53%

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Differentiation of the Osteochondrogenic Cells of the Periosteum in Chondrotrophic Environment

Poussa

Rubak

Ritsilä

1981

Acta Orthopaedica Scandinavica

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supporting

confidence: 53%

“…In earlier periosteal transplantation studies (Poussa & Ritsila 1979, Poussa et al 1980) bone formation occurred enchondrally, i.e. through a cartilage interphase.…”

Section: Discussionmentioning

confidence: 99%

Differentiation of the Osteochondrogenic Cells of the Periosteum in Chondrotrophic Environment

Poussa

Rubak

Ritsilä

1981

Acta Orthopaedica Scandinavica

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“…Using histomorphology and ultrastructure CT examinations, several researchers have found that removing periosteum from living autogenous bone leads to a 73% decrease in new bone and cartilage, a 10-fold decrease in new vessels, and a 75% decrease in osteoclasts [ 12 ]. Poussa et al [ 13 ] examined microangiographic technology and found that capillaries formed, without a blood supply, in the first day after free periosteum grafting. Capillaries can enter directly into the germinal layer of the free periosteum through the surrounding soft tissues and support the osteogenesis.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Combined Therapy of Periosteum and Bone Allograft in a Critical-Sized Defect Model in New Zealand White Rabbits

Zhang

Huang

et al. 2014

Med Sci Monit

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BackgroundLarge segmental bone defects caused by trauma, infection, or bone tumor resection are difficult to cure and have been a problem in the field of bone repair for decades. The objective of this study was to discuss the efficacy of combined therapy of free periosteum and bone allograft in treating bone defects and to provide a theoretical basis for clinical application of this therapy.Material/MethodsA unilateral tibia cortical defect model in New Zealand white rabbits was established according to Girolamo method. Total 48 rabbits were randomized into 3 groups: a simple bone defect group (n=16), an autogenous bone graft group (n=16), and a periosteum and bone allograft combined therapy group (n=16). The efficacy was evaluated by imaging inspections and scoring, HE staining, and RT-PCR in postoperative weeks 2, 4, 8, and 12.ResultsThe results of imaging and histopathological inspections in the study indicated that in postoperative weeks 4, 8, and 12 the experimental and control groups had statistically significant differences in Lane-Sandhu radiographic scoring and relative bone density when compared with the simple bone defect group (P<0.05). The RT-PCR results suggested that the expression of SPP-1, BMP-2, and VEGF in the experimental group was higher than in the control group (P<0.05) and the expression of Col Iα1 in the control group was higher than in the experimental group (P<0.05).ConclusionsEfficacies of the combined therapy (periosteum combined with bone allografting) and the criterion standard therapy (autogenous bone grafting) are equivalent in treating bone defects in New Zealand white rabbits.

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Autogenous osteoperiosteal grafts in the reconstruction of full-thickness joint surface defects

Korkala

Kuokkanen

1991

International Orthopaedics

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Free, autogenous periosteal grafts from the medial metaphysis of the proximal tibia have been used to reconstruct full thickness cartilage defects of the articular surfaces of the knee joint. If there was a bone defect, it was initially filled with cancellous bone graft. The method is illustrated by six patients, three with acute traumatic patellar defects and three with local sclerotic osteochondritis of the medial femoral condyle. The latter had loose fragments unsuitable for fixation and single excision would have left a large and deep defect. The grafts have given satisfactory results, 14 to 59 months after the procedures. Clinical grading of the defects has been monitored by radiographs with arthroscopy of two knees and CT scan of one knee.

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The Effect of the Thickness of the Cortical Bone on Bone Formation by Osteoperiosteal Grafts:A Comparative Study Employing Routine Histological Stains and Triple Fluorochrome Labelling

Cited by 6 publications

References 11 publications

Differentiation of the Osteochondrogenic Cells of the Periosteum in Chondrotrophic Environment

Differentiation of the Osteochondrogenic Cells of the Periosteum in Chondrotrophic Environment

Efficacy of Combined Therapy of Periosteum and Bone Allograft in a Critical-Sized Defect Model in New Zealand White Rabbits

Autogenous osteoperiosteal grafts in the reconstruction of full-thickness joint surface defects

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