The effect of the type of dietary protein on the development of ovarian cancer

Taha, Ahmed A.A; Koshiyama, Masafumi; Matsumura, Noriomi; Abiko, Kaoru; Yamaguchi, Ken; Hamanishi, Junzo; Baba, Tsukasa; Kharma, Budiman; Mohamed, Ibrahim Hassanin; Ameen, Magdy Mohamed; Ismail, Salah A.; Konishi, Ikuo; Mandai, Masaki

doi:10.18632/oncotarget.25253

Cited by 13 publications

(17 citation statements)

References 53 publications

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“…26 Structural proteins like meat and fish proteins are less efficient in elevating the insulin and IGF-1 plasma concentrations than milk proteins. 27,28 Milk contains leucine, glutamine, palmitate that promote more than others the activation of mTORC1 (serine and threonine protein kinase that regulates cell growth, proliferation, motility and survival, synthesis protein, and transcription). 29,30 3.9% of the milk composition is also characterized by fats, 98% of which by triglycerides, (approximately 65% of the total is made up of saturated fatty acids, mainly represented by palmitic acid which accounts for approximately 30% by weight of the total fatty acids, myristic acid and stearic acid.…”

Section: Nutrition In Cancer Carementioning

confidence: 99%

Integrative Treatment of Lung Cancer Patients: Observational Study of 57 Cases

Anelli¹,

Nardo²,

Bonucci³

2021

ASJO

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Introduction A retrospective clinical study was performed to identify the characteristics of patients with lung cancer treated with integrative cancer treatment in addition to conventional medicine. Materials and Methods We reviewed medical records for lung cancer patients who visited a single integrative setting in Rome, Italy. A total of 57 patients were included, and the majority had advanced-stage cancer. All of them underwent integrative therapy with nutrition and phytotherapy indications. The diet was designed to reduce most of possible factors promoting cancer proliferation, inflammation, and obesity. Foods with anti-inflammatory, prebiotic, antioxidant, and anticancer properties had been chosen. Herbal supplements with known effects on lung cancer were prescribed. In particular, astragal, apigenine, fucosterol, polydatin, epigallocatechin gallate, cannabis, curcumin, and inositol were used. Furthermore, medical mushrooms and other substances were used to improve the immune system and to reduce chemotherapy side effects. Five key parameters have been evaluated for 2 years starting at the first surgery: nutritional status, immune status, discontinuation of therapy, quality of life, and prognosis of the disease. Results A relevant improvement in parameters relative to nutritional status, immune status, and quality of life has been observed after integrative therapy compared with the same parameters at the first medical visit before starting such approach. Conclusion The results suggest that integrative therapy may have benefits in patients with lung cancer. Even though there are limitations, the study suggests that integrative therapy could improve nutritional status and quality of life, with possible positive effect on overall survival.

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Section: Nutrition In Cancer Carementioning

confidence: 99%

Integrative Treatment of Lung Cancer Patients: Observational Study of 57 Cases

Anelli¹,

Nardo²,

Bonucci³

2021

ASJO

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“…High-grade serous carcinoma reflects the classic clinical picture of ovarian cancer that is highly sensitive to anticancer drugs. More than 90% of cases have TP53 mutations, and about half are thought to originate from the fallopian tube [9,10]. On the other hand, low-grade serous carcinoma is thought to occur in the background of serous borderline malignant tumors, with few cases of advanced disease; however, proliferative activity and anticancer drug sensitivity are low.…”

Section: Appendices I Serous Carcinomamentioning

confidence: 99%

“…On the other hand, low-grade serous carcinoma is thought to occur in the background of serous borderline malignant tumors, with few cases of advanced disease; however, proliferative activity and anticancer drug sensitivity are low. Low-grade serous carcinoma has been reported to have many cases with KRAS and BRAF somatic mutations [9,10]. Although the estrogen receptor is positive, the effectiveness of hormonal therapy has not been verified in clinical studies [9,10].…”

Section: Appendices I Serous Carcinomamentioning

confidence: 99%

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Potential Novel Ovarian Cancer Treatment Targeting Myeloid-Derived Suppressor Cells

Hayashi¹,

Abiko²,

Yamaguchi³

et al. 2020

CROGR

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Diagnosis by biopsy is difficult in the ovary, since it is located deep in the abdomen. As a result, ovarian cancer is mostly found insidiously during exploratory laparotomy. Consequently, early diagnosis of ovarian cancer is often difficult. The likelihood of peritoneal dissemination increases with the progress of ovarian cancer. With further progression, ovarian cancer metastasizes to the omentum, retroperitoneal lymph nodes, large intestine, small intestine, diaphragm, spleen, and other organs. Ovarian cancer has been considered a tumor that has a favourable response to chemotherapy, but more effective treatments are still being explored. Tumors use their own immune escape mechanism to evade host immunity. The immune checkpoint (IC) mechanism, one of the immune escape mechanisms, is established by programmed cell death-1 (PD-1)/PDligand-1 (PD-L1) communication. It has been shown that inhibiting PD-1/PD-L1 communication in various malignancies produces antitumor effects. However, the antitumor effect of ICI monotherapy on ovarian cancer is limited in actual clinical practice. In this review, we describe a novel cancer immunotherapeutic agent that targets myeloid-derived suppressor cells (MDSCs).

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“…In another population-based case-control study in the USA, an increased whole milk consumption and the intake of lactose was associated with a higher risk of developing ovarian cancer (highest quartile vs. lowest: OR = 1.97 p = 0.008). Using mouse models, our group evaluated whether different dietary protein qualities involving animal (casein: extracted from milk) or plant protein (soy protein) could inhibit ovarian cancer growth [130]. We found that the PI3K/AKT/mTOR pathway, a downstream signaling pathway of IGF-1, was more strongly activated by the intake of animal protein (casein) than the intake of plant protein (soy protein) in mice with ovarian cancer.…”

Section: Ovarian Cancermentioning

confidence: 99%

The Effects of the Dietary and Nutrient Intake on Gynecologic Cancers

Koshiyama

2019

Healthcare

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The contribution of diet to cancer risk has been considered to be higher in advanced countries than in developing countries. In this paper, I review the current issues (a review of the relevant literature), and the effects of the dietary and nutrient intake on three types of gynecologic cancer (cervical, endometrial and ovarian cancers). In cervical cancer, the most important roles of diet/nutrition in relation to cancer are prophylaxis and countermeasures against human papillomavirus (HPV) infection. The main preventive and reductive factors of cervical cancer are antioxidants, such as vitamin A, C, D and E, carotenoids, vegetables and fruits. These antioxidants may have different abilities to intervene in the natural history of diseases associated with HPV infection. For endometrial cancer, the increase in peripheral estrogens as a result of the aromatization of androgens to estrogens in adipose tissue in obese women and insulin resistance are risk factors. Thus, we must mainly take care to avoid the continuous intake of fat energy and sugar. In ovarian cancer, the etiology has not been fully understood. To the best of our knowledge, the long-term consumption of pro-inflammatory foods, including saturated fat, carbohydrates and animal proteins is a risk factor. The intake of acrylamide is also a risk factor for both endometrial and ovarian cancer. Most papers have been epidemiological studies. Thus, further research using in vitro and in vivo approaches is needed to clarify the effects of the dietary and nutrient intake in detail.

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The effect of the type of dietary protein on the development of ovarian cancer

Cited by 13 publications

References 53 publications

Integrative Treatment of Lung Cancer Patients: Observational Study of 57 Cases

Integrative Treatment of Lung Cancer Patients: Observational Study of 57 Cases

Potential Novel Ovarian Cancer Treatment Targeting Myeloid-Derived Suppressor Cells

The Effects of the Dietary and Nutrient Intake on Gynecologic Cancers

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