The effect of the use of proton pump inhibitors, serotonin uptake inhibitors, antihypertensive, and anti‐inflammatory drugs on clinical outcomes of functional dental implants: A retrospective study

Corbella, Stefano; Morandi, Paolo; Alberti, Alice; Morandi, Benedetta; Francetti, Luca

doi:10.1111/clr.13964

Cited by 9 publications

(7 citation statements)

References 53 publications

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“…The smoking status was assessed at the time of first implant placement, through a questionnaire. Following a previous study [ 27 ], the periodontal status was assessed before the implant placement and during each follow-up visit by following the criteria by Tonetti et al [ 28 ]. site-related factors: implant location prosthesis-related factors (to be evaluated using the radiographs taken after placement of the prosthesis): prosthesis type (single crown or partial fixed denture), fixation methods (screwed or cemented), platform switching, crown height (I-CH), extension of prosthetic cantilever (only for single-tooth restorations) (mesial and / or distal) (C-M, C-D), angle of emergence profile (mesial and distal) (C-M-EP, C-D-EP) which is calculated as the angle between the implant axis and the line tangent to the prosthetic crown [ 18 ], presence of misfit between the prosthesis itself and the abutment.…”

Section: Methodsmentioning

confidence: 99%

The influence of implant position and of prosthetic characteristics on the occurrence of peri-implantitis: a retrospective study on periapical radiographs

Corbella,

Morandi,

Calciolari

et al. 2023

Clin Oral Invest

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Objective The present retrospective study aimed to investigate the influence of malposition on the occurrence of peri-implantitis. Materials and methods The study included clinical records of systemically healthy patients with single and partial implant-supported rehabilitations and at least 1-year post-loading follow-up. The parameters collected included implant-related factors, patient-related factors, site-related factors, and prosthesis-related factors. The radiographic measurements were taken by using a dedicated software and the diagnosis of peri-implantitis was made based on all the available clinical and radiographic data. Descriptive statistics were provided for all variables. Following an exploratory approach, an implant-level analysis of factors influencing the occurrence of peri-implantitis was done through a multilevel multivariate logistic regression (mixed). Results A total of 180 implants belonging to 90 subjects were randomly selected. Malposition showed no statistically significant association with the occurrence of peri-implantitis. According to the multi-level analysis, the parameters that were significantly associated with peri-implantitis included presence / history of periodontitis (OR = 5.945, 95% CI: 1.093 – 32.334, P = 0.039) and presence of an emergence profile angle ≥ 45° (OR = 9.094, 95% CI: 2.017 – 40.995, P = 0.005). Conclusions Implant malposition, as defined following Buser’s criteria (2004), did not influence the occurrence of peri-implantitis in the selected cohort. Conversely, history of periodontitis and presence of a prosthetic emergence profile with an angle ≥ 45° were correlated to an increased risk of peri-implantitis.

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Section: Methodsmentioning

confidence: 99%

The influence of implant position and of prosthetic characteristics on the occurrence of peri-implantitis: a retrospective study on periapical radiographs

Corbella,

Morandi,

Calciolari

et al. 2023

Clin Oral Invest

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“…Altay et al [ 1 ] reported negative effect on EIF in PPI users. Conversely, Corbella et al [ 18 ] reported that the use of PPIs, appeared to have no influence on implant survival.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Proton Pump Inhibitors on Early Implant Failure A Retrospective Cohort Study

Masri

Retzkin

Souza³

et al. 2023

Medicina

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Background and Objectives: Maintenance of a firm and long-term stable osseointegration is the primary goal of implant dentistry. Time is used to define implant failure characteristics. Early implant failure (EIF) occurs up to one year after loading. Recent studies indicated an association between proton pump inhibitors (PPI) therapy and failure of osseointegration. The present study assessed whether the use of PPIs is a risk factor to EIF. Materials and methods: A retrospective cohort study including 687 patients and 2971 dental implants. The study group (PPIs users) comprised 17.3% (119) individuals and 18.7% (555) implants. The remaining cohort (82.7% (568) individuals and 81.3% (2416) implants) served as control. The information was taken from the patients’ files. The following information was collected: age, gender, physical status, systemic diseases, HbA1C values before and after implant-supported prosthesis delivery in cases of diabetes mellitus, smoking, implant location, number of implants per individual, bone augmentation, implant brand, length and width, and EIF. EIF was defined as implant removal within a period of up to 12 months from loading. Results: EIF in PPIs vs. non-PPIs users was 19.3% vs. 14.3% (p = 0.16) at patient level and 5.4% vs. 3.5% at implant level (p = 0.03). Univariate analysis yielded factors significantly associated with PPIs use, including older age, physical status of the American Society of Anesthesiology (ASA) 3, hypertension, hyperlipidemia, diabetes mellitus, osteoporosis, cardiovascular accident (CVA), location (anterior mandible), shorter and narrower implants, and higher number of implants per individual. Multivariate analysis yielded statistically significant OR of 1.91; p = 0.01 for EIF following PPIs use and 2.3; p < 0.001 for location in anterior mandible. Conclusions: Patients and their healthcare providers are advised to carefully consider the potential risks of taking PPIs prior to dental implant surgery. Further research is needed to confirm these risks and elucidate systemic and local factors that may be involved in such outcomes.

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“…331 Another recent retrospective study 332 found that patients using nonsteroidal anti-inflammatory drugs (NSAIDs) presented significantly higher levels of peri-implantitis than control patients, whereas the researchers did not find an influence on implant survival or an augmented risk of peri-implantitis in patients taking SSRI drugs, proton pump inhibitors, or antihypertensive medications. 332 The authors concluded regarding SSRIs that even when the association between SSRIs and implant failure or peri-implantitis is biologically plausible, there is a need for more research to confirm these findings. 332 As stated above, serotonin can regulate osteoblast/osteoclast balance and so SSRIs may modify the activation and differentiation of osteoclasts 315 and reduce osteoblast differentiation and mineralization.…”

Section: Selectiveserotoninreuptakeinhibitorsmentioning

confidence: 99%

“…332 The authors concluded regarding SSRIs that even when the association between SSRIs and implant failure or peri-implantitis is biologically plausible, there is a need for more research to confirm these findings. 332 As stated above, serotonin can regulate osteoblast/osteoclast balance and so SSRIs may modify the activation and differentiation of osteoclasts 315 and reduce osteoblast differentiation and mineralization. 326 This negative impact on bone metabolism regulation was verified by a reduction of osteoblast marker genes like alkaline phosphatase, osteocalcin, and Osterix.…”

Section: Selectiveserotoninreuptakeinhibitorsmentioning

confidence: 99%

Emerging factors affecting peri‐implant bone metabolism

Insua,

Galindo‐Moreno,

Miron

et al. 2023

Periodontology 2000

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Implant dentistry has evolved to the point that standard implant osseointegration is predictable. This is attributed in part to the advancements in material sciences that have led toward improvements in implant surface technology and characteristics. Nonetheless, there remain several cases where implant therapy fails (specifically at early time points), most commonly attributed to factors affecting bone metabolism. Among these patients, smokers are known to have impaired bone metabolism and thus be subject to higher risks of early implant failure and/or late complications related to the stability of the peri‐implant bone and mucosal tissues. Notably, however, emerging data have unveiled other critical factors affecting osseointegration, namely, those related to the metabolism of bone tissues. The aim of this review is to shed light on the effects of implant‐related factors, like implant surface or titanium particle release; surgical‐related factors, like osseodensification or implanted biomaterials; various drugs, like selective serotonin reuptake inhibitors, proton pump inhibitors, anti‐hypertensives, nonsteroidal anti‐inflammatory medication, and statins, and host‐related factors, like smoking, diet, and metabolic syndrome on bone metabolism, and aseptic peri‐implant bone loss. Despite the infectious nature of peri‐implant biological complications, these factors must be surveyed for the effective prevention and management of peri‐implantitis.

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The effect of the use of proton pump inhibitors, serotonin uptake inhibitors, antihypertensive, and anti‐inflammatory drugs on clinical outcomes of functional dental implants: A retrospective study

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 9 publications

References 53 publications

The influence of implant position and of prosthetic characteristics on the occurrence of peri-implantitis: a retrospective study on periapical radiographs

The influence of implant position and of prosthetic characteristics on the occurrence of peri-implantitis: a retrospective study on periapical radiographs

The Effect of Proton Pump Inhibitors on Early Implant Failure A Retrospective Cohort Study

Emerging factors affecting peri‐implant bone metabolism

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