The effect of three-month topical testosterone gel application on semen quality in men with oligozoospermia and low serum testosterone levels

Abstract

Objective: The effects of daily topical application of testosterone gel on semen characteristics in infertile men with oligozoospermia and hypogonadism were assessed. Methods: Sixteen infertile men were included in this prospective study. A daily morning application of 25 mg transdermal testosterone (T) gel was used for 3 months. Semen parameters, serum follicular stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E) and T levels, and seminal plasma E and T levels were measured before treatment and once monthly for three months during the therapy. Results: The baseline median sperm concentration was 5.5 × 106/mL. Median sperm concentrations at the first, second and third months were 9 × 106, 8 × 10 6, and 4 × 106/mL, respectively. The sperm concentrations at the first and second months after starting therapy significantly (p < 0.001) increased compared with the baseline. However, sperm volume, pH, motility, viability and morphology were similar to baseline. Serum T significantly (p < 0.001) increased, while serum FSH significantly (p < 0.001) decreased from baseline. Seminal T and T/E ratios were raised significantly (p = 0.008 and p = 0.004, respectively) after gel application, whereas the seminal E level was not affected. Conclusions: Daily 25 mg T gel applications for oligospermic infertile men with hypogonadism increased the sperm concentration at the first and second months and raised the serum T level to the normal adult male range. Nevertheless, the sperm concentration had a decreasing trend after the third month.

Kết Quả Điều Trị Bằng Testosterone Thay Thế Trên Bệnh Nhân Suy Sinh Dục Nam Tại Bệnh Viện Trường Đại Học Y Dược Cần Thơ

“…Tất cả các nhóm đều đáp ứng với điều trị, giãn tĩnh mạch tinh độ III thì đáp ứng thấp nhất (từ 5,56 lên 5,92 nmol/L). Tác giả Thanaboonyawat ghi nhận tỷ lệ testosterone tăng lên đáng kể (p = 0,008) sau khi bôi gel 3 tháng liên tiếp [10]. Tác giả Ramasamy R ghi nhận tỷ lệ testosterone tăng lên đáng sau khi bôi gel 3 tháng liên tiếp (p<0,05) [11].…”