The effect of thymoquinone on intractable pediatric seizures (pilot study)

Akhondian, Javad; Kianifar, Hamidreza; Raoofziaee, Mohammad; Moayedpour, Amir; Toosi, Mehran Beiraghi; Khajedaluee, Mohammad

doi:10.1016/j.eplepsyres.2010.10.010

Cited by 82 publications

(41 citation statements)

References 9 publications

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“…The blurred literature on α-thujone, a wrongly identified cannabinoid ligand but actually a GABA-A modulator [16], and the controversies surrounding the scientific bases of aromatherapy [15] might have substantially relegated the investigation on the neurological relevance of plant volatiles to the realm of olfaction, where their preeminence is unquestionable [21]. The study of TRPs and cannabinoid receptors [11], and the current clinical interest for essential oil constituents like thymoquinone [1] or menthol [8], are now bringing volatile compounds to the forefront of the biomedical research. Fig.…”

Section: Discussionmentioning

confidence: 98%

“…Pipette solution contained (millimolar): 100 K-Aspartate; 40 KCl; 2 MgCl 2 ; 4 Na 2 -ATP, 5 EGTA, and 1.2 CaCl 2 for buffering at 50 nM free Ca 2+ , 10 HEPES, and KOH to pH 7.2. [1]), its non-electrophilic derivates [2][3][4][5], and its naturally occurring analogs [6][7][8]. [ Statistical analyses Statistical analysis and graphical presentations were performed using the Origin ver.…”

Section: Methodsmentioning

confidence: 99%

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Umbellulone modulates TRP channels

Zhong

Minassi

Prenen

et al. 2011

Pflugers Arch - Eur J Physiol

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Inhalation of umbellulone (UMB), the offensive principle of the so-called "headache tree" (California bay laurel, Umbellularia californica Nutt.), causes a painful cold sensation. We therefore studied the action of UMB and some derivatives devoid of thiol-trapping properties on the "cold" transient receptor potential cation channels TRPA1 and TRPM8. UMB activated TRPA1 in a dose-dependent manner that was attenuated by cysteine-to-serine isosteric mutation in TRPA1 (C622S), while channel block was observed at higher concentration. However, although activation by mustard oil was completely prevented in these mutants, UMB still retained activating properties, indicating that it acts on TRPA1 only as a partial electrophilic agonist. UMB also activated TRPM8, but to a lower extent than TRPA1. Removing Michael acceptor properties of UMB (reduction or nucleophilic trapping) was detrimental for the activation of TRPA1, but increased the blocking potency. This was, however, attenuated by acetylation of the hydroxylated analogs. All UMB derivatives, except the acetylated derivatives, were also TRPM8 activators. They acted, however, in a bimodal manner, inhibiting the channel more potently than UMB, and with tetrahydro-UMB being the most potent TRPM8 activator. In conclusion, UMB is a bimodal activator of TRPA1 and a weak activator of TRPM8. Non-electrophilic derivatives of UMB are better TRPM8 activators than the natural product and also potent blockers of this channel as well as of TRPA1. The lack of effects of the acetylated UMB derivatives suggests that steric hindrance may prevent access to the recognition site for the bicyclic monoterpene pharmacophore on TRPA1 and TRPM8.

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Section: Discussionmentioning

confidence: 98%

Section: Methodsmentioning

confidence: 99%

Umbellulone modulates TRP channels

Zhong

Minassi

Prenen

et al. 2011

Pflugers Arch - Eur J Physiol

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“…In this double-blind crossover clinical study, the effects of TQ (1 mg/kg/day) adjuvant therapy on the frequency of seizures were compared with those of the placebo. TQ adjuvant therapy for 4 weeks reduced the frequency of seizures in comparison with baseline and placebo group, which showed its anticonvulsant effects (Akhondian et al, 2011). Table 4 shows a summary of the clinical effects of N. sativa and its constituents on neurological disorders.…”

Section: Effects On Neurological Disordersmentioning

confidence: 98%

Preclinical and clinical effects of Nigella sativa and its constituent, thymoquinone: A review

Gholamnezhad

Havakhah

Boskabady

2016

Journal of Ethnopharmacology

234

150

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“…Previous studies reported that TQ was a promising agent because of its anticarcinogenic, antioxidant, and antiepileptic properties. [6][7][8] Therapeutic effects of TQ have been evaluated in a wide variety of different systems, including lipid and cholesterol metabolism, glucose metabolism (antidiabetic), and the gastrointestinal, circulatory, and peripheral nervous systems, as well as its antioxidant and anticarcinogenic effects. Regarding lipid and cholesterol metabolism, TQ decreases levels of total cholesterol and low-density lipoprotein and increases the level of high-density lipoprotein; therefore, it reduces the risk of cardiovascular disease development.…”

Section: Discussionmentioning

confidence: 99%

“…[6][7][8][9] However, studies analyzing the effects of TQ on the peripheral nervous system have focused only on models of neuropathic pain. [10,11] To the best of our knowledge, no studies have assessed therapeutic effects of TQ on peripheral nerves following an acute crush injury.…”

mentioning

confidence: 99%