The Effect of Thyroid Hormone Supplementation on Hemodynamic Stability and Survival in an Endotoxin-Induced Model of Physiologic Stress

Glembot, Troy M.; Hill, Michael A.; Britt, L. D.

doi:10.1006/jsre.1996.0084

Search citation statements

Order By: Relevance

Paper Sections

Select...

Discussion1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2003

2011

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When the T4 levels were below 3 µg/dl, the mortality rate increased from 64% to 84%, whereas the mortality was only 22% at normal levels of serum T4. 21,46 Glembot et al 47 reported that the mortality did not decrease with thyroid hormone supplementation in an endotoxin-induced physiologic-stress model. This result suggests that thyroid hormones are not effective in endotoxin-induced physiologic stress, though they have a remarkable effect on the intracellular digestion and killing of bacteria in the neutrophil function.…”

Section: Discussionmentioning

confidence: 98%

Thyroid Hormone Supplementation in Sepsis: An Experimental Study

et al. 2003

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 98%

Thyroid Hormone Supplementation in Sepsis: An Experimental Study

et al. 2003

View full text Add to dashboard Cite

show abstract

Stability of thyroid hormones during continuous infusion

Golombek

Alpan²,

Frey³

et al. 2011

Journal of Perinatal Medicine

View full text Add to dashboard Cite

We investigated the stability of thyroid hormones during a mode of continuous drug infusion via polypropylene tubing using the same conditions that would be applied to treating patients in a hospital setting. The diluted thyroid hormones were prepared using aseptic technique, stored at 2-8°C (36-46°F) and tested within 24 h of preparation for stability and percent recovery from within plastic tubing. Experiments were done in duplicate with triplicate sets of readings for each assay point. Only T(4) prepared with 5% dextrose water (D5W) containing 1 mg/mL albumin remained constant, stable, predictable and accurate over time under various conditions. Other methods of preparation lost drug by adhering to the plastic containers and tubing by as much as 40% of starting concentration. T(3) recovery in the presence of 1 mg/mL of albumin was 107±2% (mean±standard error of the mean) of anticipated drug concentrations. We conclude from this series of experiments that to maintain an accurate and stable dosing of patients receiving intravenous thyroid hormones, 1 mg/mL of albumin must be added to the infusate to prevent lost on the plastic intravenous tubing.

show abstract

The Effect of Thyroid Hormone Supplementation on Hemodynamic Stability and Survival in an Endotoxin-Induced Model of Physiologic Stress

Cited by 2 publications

References 4 publications

Thyroid Hormone Supplementation in Sepsis: An Experimental Study

Thyroid Hormone Supplementation in Sepsis: An Experimental Study

Stability of thyroid hormones during continuous infusion

Contact Info

Product

Resources

About