1978
DOI: 10.1210/endo-103-5-1759
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The Effect of Thyroidectomy, Hypophysectomy, and Hormone Replacement on the Formation of Triiodothyronine from Thyroxine in Rat Liver and Kidney*

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1979
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Cited by 54 publications
(18 citation statements)
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“…These effects of thyroid status on placental deiodinating activity seemed to be placenta specific, because there were significant changes in T4 to T3 deiodination in the liver and kidney in pregnant rats in the present study as well as in the previous reports on non-pregnant rats (Balsam et al, 1978;Kaplan et al, 1978;Harris et al, 1978). In human placenta, we also reported that there was no significant change in the placental deiodinating activity in hyperthyroid patients (Yoshida et al, 1985).…”
Section: Discussionsupporting
confidence: 76%
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“…These effects of thyroid status on placental deiodinating activity seemed to be placenta specific, because there were significant changes in T4 to T3 deiodination in the liver and kidney in pregnant rats in the present study as well as in the previous reports on non-pregnant rats (Balsam et al, 1978;Kaplan et al, 1978;Harris et al, 1978). In human placenta, we also reported that there was no significant change in the placental deiodinating activity in hyperthyroid patients (Yoshida et al, 1985).…”
Section: Discussionsupporting
confidence: 76%
“…Balsam et al (1978) demonstrated that the T4 metabolism in slices of rat liver and kidney was greatly affected by both thyroidectomy and hypophysectomy and that these effects were apparently due to the lack of thyroid hormone since they could be recovered by the administration of thyroid hormone. Our results in rat liver and kidney are in good concordance with those previously reported.…”
Section: Discussionmentioning
confidence: 99%
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“…Peripheral conversion of T4 to T3 is modulated by several conditions, such as thyroid hormone excess and deficiency (2,5,15,17,18), stress (8,9), age (13,15,36), sex (14) and dietary effects (3, 4, 12, 15, 19, 29, 30, 33). In each situation, however, the mechanism by which conversion of T4 to T3 is regulated may be different.…”
Section: Discussionmentioning
confidence: 99%
“…T3-neogenesis in rat liver (36,37), and, in the rat, thyroid hypofunction is a consequence of fasting (33,38).…”
mentioning
confidence: 99%