The Effect of Titanium Surface Modifications on Dental Implant Osseointegration

Annunziata, Marco; Guida, Luigi

doi:10.1159/000381694

Cited by 61 publications

(49 citation statements)

References 57 publications

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“…[1][2][3][4] Titanium and medical-grade Ti6Al4V alloy are the most popular materials, and have been widely used to fabricate dental implants owing to their favorable mechanical properties and intrinsic ability for promoting osseointegration, among other characteristics. [5][6][7][8] The main problem in dental implant therapy lies in a poor and delayed osseointegration, which might lead to failure of the dental implant therapy. [9][10][11] The success rate of dental implants significantly depends on the osseointegration ability of the implants.…”

Section: Introductionmentioning

confidence: 99%

Enhanced growth and osteogenic differentiation of MC3T3-E1 cells on Ti6Al4V alloys modified with reduced graphene oxide

Lin

Wang

2017

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Enhanced growth and osteogenic differentiation of MC3T3-E1 cells on Ti6Al4V alloys modified with reduced graphene oxide

Lin

Wang

2017

RSC Adv.

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“…Titanium and medical grade Ti6Al4V alloy are the most prevalent materials used to fabricate dental and orthopaedic implants, primarily due to their suitable mechanical properties and intrinsic ability to support osseointegration 1 . The effectiveness of this process is governed by the interactions that occur at the outermost surface layer over a few atomic distances with the host extracellular matrix and local cell population.…”

mentioning

confidence: 99%

Self-assembled monolayers of alendronate on Ti6Al4V alloy surfaces enhance osteogenesis in mesenchymal stem cells

Rojo

Gharibi

McLister³

et al. 2016

Sci Rep

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Phosphonates have emerged as an alternative for functionalization of titanium surfaces by the formation of homogeneous self-assembled monolayers (SAMs) via Ti-O-P linkages. This study presents results from an investigation of the modification of Ti6Al4V alloy by chemisorption of osseoinductive alendronate using a simple, effective and clean methodology. The modified surfaces showed a tailored topography and surface chemistry as determined by SEM microscopy and RAMAN spectroscopy. X-ray photoelectron spectroscopy revealed that an effective mode of bonding is created between the metal oxide surface and the phosphate residue of alendronate, leading to formation of homogenous drug distribution along the surface. In-vitro studies showed that alendronate SAMs induce differentiation of hMSC to a bone cell phenotype and promote bone formation on modified surfaces. Here we show that this novel method for the preparation of functional coatings on titanium-based medical devices provides osseoinductive bioactive molecules to promote enhanced integration at the site of implantation.

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“…(i,j) ALP protein expression in four groups of hBMSCs at day 7. Error bars are the mean ± SD, *p < 0.05; **p < 0.01, n = 3 the surface of Ti include plasma spraying, anodizing, sand blasting, acid etching or sand blasting and acid etching (Annunziata & Guida, 2015). SLA implants with microtopography are the most commonly used implants in the clinic.…”

Section: Discussionmentioning

confidence: 99%

Microarray analysis reveals that lncRNA PWRN1‐209 promotes human bone marrow mesenchymal stem cell osteogenic differentiation on microtopography titanium surface in vitro

Wang

Zheng

et al. 2020

J Biomed Mater Res

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Sandblasted, large‐grit, and acid‐etched (SLA) titanium (Ti) with microtopography is currently one of the most widely used implant materials to accelerate osseointegration. Numerous long noncoding RNAs (lncRNAs) have been involved in bone remodeling, with their role in osseointegration, and the underlying mechanisms remain largely unclear. Here, microarrays of human bone marrow mesenchymal stem cells (hBMSCs) were used to identify differentially expressed lncRNAs during early cell differentiation stages (0–7 days) on SLA Ti and polished Ti surfaces. The function of lncRNAs in the osteogenic differentiation of hBMSCs was identified by RNA silencing and overexpression assays. RT‐PCR and Western blot were used to detect RNA and protein expression. Alkaline phosphatase (ALP) protein activity was tested by ALP staining. Altogether, 4112 differentially expressed lncRNAs were identified from day 0 to day 7 on SLA Ti with a novel lncRNA, Prader‐willi region non‐coding RNA 1‐209 (PWRN1‐209) upregulated. We then proved that PWRN1‐209 promoted osteogenic differentiation in hBMSCs by genetic tools. The upregulation of PWRN1‐209 was further confirmed to be related to the surface topography of Ti by comparing SLA Ti and polished Ti. Interestingly, this trend seems to have a certain correlation with the mRNA expression level of integrins (α2, αV, β1, β2) and the phosphorylation of focal adhesion kinase (FAK). Taken together, the lncRNA PWRN1‐209 was upregulated by the SLA microtopography Ti surface, which may regulate osteogenic differentiation of hBMSCs through integrin‐FAK‐ALP signaling. Our results provide new insights into the relationship between surface topography and osseointergration.

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The Effect of Titanium Surface Modifications on Dental Implant Osseointegration

Cited by 61 publications

References 57 publications

Enhanced growth and osteogenic differentiation of MC3T3-E1 cells on Ti6Al4V alloys modified with reduced graphene oxide

Enhanced growth and osteogenic differentiation of MC3T3-E1 cells on Ti6Al4V alloys modified with reduced graphene oxide

Self-assembled monolayers of alendronate on Ti6Al4V alloy surfaces enhance osteogenesis in mesenchymal stem cells

Microarray analysis reveals that lncRNA PWRN1‐209 promotes human bone marrow mesenchymal stem cell osteogenic differentiation on microtopography titanium surface in vitro

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