The Effect of Topical Cyclopentolate on Anterior Segment Parameters in Patients with Keratoconus

Abstract

Keratoconus is characterized by progressive thinning of the cornea, corneal steepening, and irregular astigmatism. 1 The mechanical and structural changes that take place in the corneas of patients with keratoconus lead to biomechanical weakening of the cornea. The factors that cause this include changes in collagen and extracellular matrix structure and keratocyte apoptosis. 2,3 Although patients with manifest keratoconus can be diagnosed based on slit-lamp findings such as corneal steepening, Vogt lines, Fleischer ring due to iron deposition, and fractures in Bowman's membrane that appear in advanced disease, corneal topography is currently the gold standard diagnostic method. 4 Fellow eyes of patients with manifest keratoconus that do not display the typical findings of the disease and corneas that