The effect of topical olive oil on the healing of foot ulcer in patients with type 2 diabetes: a double-blind randomized clinical trial study in Iran

Nasiri, Morteza; Fayazi, Sedigheh; Jahani, Simin; Yazdanpanah, Leila; Haghighizadeh, Mohammad Hossein

doi:10.1186/s40200-015-0167-9

Cited by 40 publications

(61 citation statements)

References 31 publications

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“…Therefore, it was difficult to be certain of the robustness of the findings. One small RCT on topical olive oil reported beneficial effect on complete healing rate ( P = .003) at 4 weeks in a per‐protocol analysis . In addition to the study where unsupervised exercise was investigated in no‐option ischaemia, we also found another nonblinded study on foot exercise, which reported a benefit at 12 weeks in a per‐protocol analysis .…”

Section: Systemic Including Medical and Nutritional Therapiesmentioning

confidence: 85%

Effectiveness of interventions to enhance healing of chronic foot ulcers in diabetes: a systematic review

Vas

Rayman

Dhatariya

et al. 2020

Diabetes Metabolism Res

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The management of diabetic foot ulcers (DFU) remains a challenge, and there is continuing uncertainty concerning optimal approaches to wound healing. The International Working Group of the Diabetic Foot (IWGDF) working group on wound healing has previously published systematic reviews of the evidence in 2008, 2012 and 2016 to inform protocols for routine care and to highlight areas which should be considered for further study. The working group has now updated this review by considering papers on the interventions to improve the healing of DFU's published between June 2014 and August 2018. Methodological quality of selected studies was independently assessed by a minimum of two reviewers using the recently published 21‐point questionnaire as recommended by IWGDF/European Wound Management Association, as well as the previously incorporated Scottish Intercollegiate Guidelines Network criteria. Of the 2275 papers identified, 97 were finally selected for grading following full text review. Overall, there has been an improvement in study design and a significant rise in the number of published studies. While previous systematic reviews did not find any evidence to justify the use of newer therapies, except for negative pressure wound therapy in post‐surgical wounds, in this review we found additional evidence to support some interventions including a sucrose‐octasulfate dressing, the combined leucocyte, fibrin and platelet patch as well as topical application of some placental membrane products, all when used in addition to usual best care. Nonetheless, the assessment and comparison of published trials remains difficult with marked clinical heterogeneity between studies: in patient selection, study duration, standard of usual care provision and the timing and description of the clinical endpoints.

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Section: Systemic Including Medical and Nutritional Therapiesmentioning

confidence: 85%

Effectiveness of interventions to enhance healing of chronic foot ulcers in diabetes: a systematic review

Vas

Rayman

Dhatariya

et al. 2020

Diabetes Metabolism Res

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“…The present results demonstrate that the therapeutic safety profile of topical treatment with olive oil is equivalent to that of HOFA treatments. No adverse effects were observed in our olive oil group, similar to findings of other studies on the topical application of olive oil on healthy skin and diabetic foot ulcers . Olive oil can therefore be considered a safe product for topical application.…”

Section: Discussionmentioning

confidence: 99%

“…These molecules endow olive oil with exceptional skincare properties, improving hydration and exerting a protective, emollient, and regenerating action . Experimental studies have demonstrated that olive oil exerts beneficial effects on the skin and promotes ulcer healing . Nevertheless, there has been no research on the efficacy of topical olive oil application for PU prevention.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness and safety of olive oil preparation for topical use in pressure ulcer prevention: Multicentre, controlled, randomised, and double‐blinded clinical trial

Díaz-Valenzuela

García-Fernández

Fernández

et al. 2019

International Wound Journal

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This non‐inferiority, multicentre, randomised, controlled, and double‐blinded clinical trial compared the therapeutic effectiveness of the topical application of an olive oil solution with that of a hyperoxygenated fatty acid compound for the prevention of pressure ulcers in at‐risk nursing home residents. The study population comprised 571 residents of 23 nursing homes with pressure ulcer risk, randomly assigned to a hyperoxygenated fatty acid group (n = 288) or olive oil solution group (n = 283). Both solutions were applied on at‐risk skin areas every 12 hours for 30 days or until pressure ulcer onset. The main outcome variable was the pressure ulcer incidence. The absolute risk difference was estimated (with 95% CI) using Kaplan‐Meier survival and Cox regression curves. The groups did not significantly differ in any study variable at baseline. The pressure ulcer incidence was 4.18% in the olive oil group vs 6.57% in the control group, with an incidence difference of −2.39% (95% CI = −6.40 to 1.56%), which is within the pre‐established non‐inferiority margin of ±7%, thus supporting the study hypothesis. We present the first evidence of the effectiveness and safety of the topical application of olive oil to prevent pressure ulcers in the institutionalised elderly.

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“…Liquid formula Oral Antimicrobial and pro-angiogenic properties [108] Sida cordifolia Linn. Hydrogel Local Antimicrobial and pro-angiogenic properties [109] Polyherbal Cream Local Antimicrobial and pro-angiogenic properties [117] Olive oil Topic Local Antimicrobial and pro-angiogenic properties [118] Nigella sativa Gel Local Antimicrobial and pro-angiogenic properties [119] Neem and Haridra Liquid formula, gel Local, oral Antimicrobial and pro-angiogenic properties [120] Hypericum and neem oil Unguent Local Antimicrobial and pro-angiogenic properties [110] Tragia involucrata In vitro study -Antimicrobial properties [111,121] Oral doses of extracts of citrus peel (lemon, grapefruit, and orange) in diabetic rats were evaluated to examine if these extracts could be beneficial in the regeneration of ulcers. The authors obtained positive outcomes in the reduction of glucose in the blood and wound healing rate and introduced this therapy as a potential therapeutic alternative for the treatment of DFUs [108].…”

Section: Plant Extract Presentation Route Of Administration Action Rementioning

confidence: 99%

“…Kiwi fruits also showed antimicrobial and pro-angiogenic features on neuropathic DFUs [113]. Finally, the impact of topical olive oil on the healing of DFUs showed a significant decrease in the DFU area [118], whereas a combination of the neem and Haridra plants to treat wounds that do not normally heal conferred healing effects when combining neem in its topical form with Haridra via oral presentation [120].…”

Section: Plant Extract Presentation Route Of Administration Action Rementioning

confidence: 99%

Diabetic Foot Ulcers: Current Advances in Antimicrobial Therapies and Emerging Treatments

et al. 2019

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Diabetic foot ulcers (DFUs) are very important diabetes-related lesions that can lead to serious physical consequences like amputations of limbs and equally severe social, psychological, and economic outcomes. It is reported that up to 25% of patients with diabetes develop a DFU in their lifetime, and more than half of them become infected. Therefore, it is essential to manage infection and ulcer recovery to prevent negatives outcomes. The available information plays a significant role in keeping both physicians and patients aware of the emerging therapies against DFUs. The purpose of this review is to compile the currently available approaches in the managing and treatment of DFUs, including molecular and regenerative medicine, antimicrobial and energy-based therapies, and the use of plant extracts, antimicrobial peptides, growth factors, ozone, devices, and nano-medicine, to offer an overview of the assessment of this condition.2 of 32 history [2]. DFUs are one of the most severe complications of diabetes, and more than half of those ulcers become infected. Every single one of these infected lesions has the potential to get worse and compromise the integrity of the lower limbs. To avoid amputations and improve the patient's quality of life, it is very important to implement a strict program for the prevention and treatment of ulcers, as well as proper management of infections [3]. Thus, it is critical to keep diabetes patients aware of new therapies and treatments and their availability in the healthcare system. The treatment of DFUs requires a multidisciplinary approach with proper medical tools, skills, and knowledge. This starts from patient education, with the application of new classifications to guide the treatment to prevent amputations. New diagnosis methods should become available, such as the 16S ribosomal DNA sequence in bacteria, to provide a better understanding of the microbiota in DFUs. It is reported that DFU has a polymicrobial nature, and, according to its geographical location, certain marked differences, wound characteristics, antibiograms according to local epidemiology, individualized antimicrobial guided therapy, regular debridement, regular assessment of wounds, and change of dressings. The latter characteristics are also aided by new biological and molecular therapies that were proven to improve infection control, the regulation of the local inflammatory profile, and improved quality of the cicatrizing process. In the next sections, this review presents an approach for the diagnosis and treatment of DFUs, focusing on the current advances in antimicrobial therapies, such as dressings,

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The effect of topical olive oil on the healing of foot ulcer in patients with type 2 diabetes: a double-blind randomized clinical trial study in Iran

Cited by 40 publications

References 31 publications

Effectiveness of interventions to enhance healing of chronic foot ulcers in diabetes: a systematic review

Effectiveness of interventions to enhance healing of chronic foot ulcers in diabetes: a systematic review

Effectiveness and safety of olive oil preparation for topical use in pressure ulcer prevention: Multicentre, controlled, randomised, and double‐blinded clinical trial

Diabetic Foot Ulcers: Current Advances in Antimicrobial Therapies and Emerging Treatments

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