The effect of topical sodium thiosulfate in experimentally induced myringosclerosis

Abstract

Our results show that sodium thiosulfate has a preventive role in the development of myringosclerosis in the experimental animal model.

Panel 8: Complications and Sequelae

“…Park et al 11 studied the effect of topical sodium thiosulfate (STS) in experimentally induced MS. Thirty Wistar albino rats were bilaterally myringotomized. The number of MS ears was significantly reduced in the STS group, and in tympanometric measurements, significantly reduced magnitudes of maximum admittance were observed in control and saline groups.…”

Pharmacokinetics of sodium thiosulfate in Guinea pig perilymph following middle ear application

“…This shows that intratympanic administration of STS may be a more effective method of delivering STS to the perilymph than intravenously. STS has been shown to be safely used ototopically in the prevention of myringosclerosis in rats at a concentration of 250 mg/mL (Park et al., 2010). Stocks et al., in 2004 found STS to be safe with application to the middle ear space of Guinea pigs at a concentration of 6% (Stocks et al., 2004).…”

“…These concentrations of STS were selected based on previous studies determining their safety. A 25% solution of STS has been used ototopically to prevent myringosclerosis in rat models and a 6% solution has also been used safely when administered ototopically in mice models (Park et al., 2010, Stocks et al., 2004). Each Guinea pig was placed under general anesthesia using inhaled 1–5% isoflurane for induction, then intubated endotracheally and placed on 2–4% isoflurane for maintenance anesthesia.…”