The effect of topography of polymer surfaces on platelet adhesion

Koh, Li Buay; Rodríguez, Isabel; Venkatraman, Subbu S.

doi:10.1016/j.biomaterials.2009.11.022

Cited by 173 publications

(178 citation statements)

References 65 publications

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“…pillars [53], lenses [54] and struts [55]. All the data taken together suggests that reducing the size of surface features (pillars, lenses, struts, or here fibers) might lead to a reduction of the contacting blood activation.…”

Section: Discussionmentioning

confidence: 90%

“…All the data taken together suggests that reducing the size of surface features (pillars, lenses, struts, or here fibers) might lead to a reduction of the contacting blood activation. Still, not only the size of the surface features matters, but also their aspect ratio, distribution and packing density [53]. Concerning electrospun fibers, aspect ratio doesn't vary with fiber diameter, but to some extent, it is possible to adjust the fiber distribution and density [56].…”

Section: Discussionmentioning

confidence: 99%

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Influence of the fiber diameter and surface roughness of electrospun vascular grafts on blood activation

et al. 2012

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Influence of the fiber diameter and surface roughness of electrospun vascular grafts on blood activation

et al. 2012

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“…Independent contributions from surface chemistry (70 %) and surface nanoroughness (30 %) were found to mediate the fibronectin adsorption [52]. Koh and coworkers demonstrated that the surface topographical features can be used to control the platelet-biomaterial interactions [61]. Surface nanoroughness is also applicable to enhance cell adhesion and growth on biomaterials [62].…”

Section: Annealing Effectmentioning

confidence: 96%

Surface characteristics and blood compatibility of PVDF/PMMA membranes

Wang

et al. 2012

J Mater Sci

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Poly(vinylidene fluoride) (PVDF)/poly(methyl methacrylate) (PMMA) membranes have important applications as biomaterials. In this study, PVDF/PMMA with varying ratios is blown into membranes, the surface property and blood compatibility of which are thoroughly investigated. Membrane surface characteristics including composition and topography exert considerable influence on the blood compatibility. Introduction of PMMA disturbs PVDF crystallization, however, favors the b phase crystal formation. PVDF content, crystallization ability, and surface enrichment have decisive effects on the membrane surface composition. Meanwhile, with increased PMMA fraction, the membrane surface roughness is also increased, and subsequently results in decreased hemocompatibility. While the membranes with PMMA content lower than 30 wt% show good blood compatibility, those with higher PMMA fraction exhibit obvious platelet adhesion to the surface. Thermal annealing promotes the formation of b phase PVDF and generates much smoother surface, thus endowing the membranes with greatly enhanced blood compatibility. These results show the prospect for optimization of processability, surface property, and blood compatibility of PVDF/PMMA membranes through facile modulation of PMMA content and fabrication process.

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“…Therefore, it is necessary to further modify the surface properties with other approaches, such as the immobilization of biomolecules, to reduce the hemolysis rate. Generally speaking, human plasma proteins firstly adsorb in seconds to the biomaterials surface when a biomaterial makes contact with blood [31]. Subsequently, the platelets will be attached on the surface followed by complement activation and other blood cell responses, finally leading to thrombus formation [32].…”

Section: Anticoagulationmentioning

confidence: 99%

Improving Corrosion Resistance and Biocompatibility of Magnesium Alloy by Sodium Hydroxide and Hydrofluoric Acid Treatments

et al. 2016

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Abstract:Owing to excellent mechanical property and biodegradation, magnesium-based alloys have been widely investigated for temporary implants such as cardiovascular stent and bone graft; however, the fast biodegradation in physiological environment and the limited surface biocompatibility hinder their clinical applications. In the present study, magnesium alloy was treated by sodium hydroxide (NaOH) and hydrogen fluoride (HF) solutions, respectively, to produce the chemical conversion layers with the aim of improving the corrosion resistance and biocompatibility. The results of attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and X-ray photoelectron spectroscopy (XPS) indicated that the chemical conversion layers of magnesium hydroxide or magnesium fluoride were obtained successfully. Sodium hydroxide treatment can significantly enhance the surface hydrophilicity while hydrogen fluoride treatment improved the surface hydrophobicity. Both the chemical conversion layers can obviously improve the corrosion resistance of the pristine magnesium alloy. Due to the hydrophobicity of magnesium fluoride, HF-treated magnesium alloy showed the relative better corrosion resistance than that of NaOH-treated substrate. According to the results of hemolysis assay and platelet adhesion, the chemical surface modified samples exhibited improved blood compatibility as compared to the pristine magnesium alloy. Furthermore, the chemical surface modified samples improved cytocompatibility to endothelial cells, the cells had better cell adhesion and proliferative profiles on the modified surfaces. Due to the excellent hydrophilicity, the NaOH-treated substrate displayed better blood compatibility and cytocompatibility to endothelial cells than that of HF-treated sample. It was considered that the method of the present study can be used for the surface modification of the magnesium alloy to enhance the corrosion resistance and biocompatibility.

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The effect of topography of polymer surfaces on platelet adhesion

Cited by 173 publications

References 65 publications

Influence of the fiber diameter and surface roughness of electrospun vascular grafts on blood activation

Influence of the fiber diameter and surface roughness of electrospun vascular grafts on blood activation

Surface characteristics and blood compatibility of PVDF/PMMA membranes

Improving Corrosion Resistance and Biocompatibility of Magnesium Alloy by Sodium Hydroxide and Hydrofluoric Acid Treatments

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