The Effect of Total Thyroidectomy Upon Experimental Diabetes Insipidus in Dogs

Mahoney, W. A.; Sheehan, Donal

doi:10.1152/ajplegacy.1935.112.2.250

Cited by 28 publications

(5 citation statements)

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“…Thyroid extracts increase urine flow in man and laboratory animals [40,44,56,92], most of the increment apparently being free water [58], Thus, thyroxine injections enhance the ability o f the kidney to excrete a water load [79] and protect the animals from water intoxi cation [58]. This diuretic effect is even more marked when urine flows are already high: The polyuria of diabetes insipidus is strikingly augmented by thyroid hormone and improved by thyroidectomy [15,66,94,144].…”

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confidence: 99%

Thyroid Hormone and the Kidney

Katz

Emmanouel

Lindheimer

1975

Nephron

174

127

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Thyroid hormones affect both renal morphology and function. They are required for kidney growth and development, and thyroid deficiency results in decreased renal plasma flow and glomerular filtration rate and in impaired urinary concentration and dilution. Thyroid hormones also influence membrane transport and electrolyte metabolism, and alterations in mineral metabolism in hyperthyroidism frequently cause calcium nephropathy which affects renal function adversely. The kidney plays an important role in the peripheral metabolism of iodine and thyroid hormones, and thyroid function is altered in certain kidney diseases, particularly chronic renal failure. The pathogenesis of these alterations is currently under active investigation.

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confidence: 99%

Thyroid Hormone and the Kidney

Katz

Emmanouel

Lindheimer

1975

Nephron

174

127

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“…Total thyroidectomy has relieved diabetes insipidus in experimental animals 113 and in human beings. Blotner and Cutler 114 reported that thyroidectomy produced a marked and persistent (for five years at least) improvement in both the diabetes insipidus and the Parkinson's disease of 2 young men whose symptoms followed encephalitis.…”

Section: The Posterior Lobe Of the Pituitarymentioning

confidence: 99%

Review of the Literature on the Pituitary Gland (1940 and 1941)

Hildebrand¹

1943

Arch Intern Med

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“…Several authors have reported improvement of polyuria in experimental diabetes insipidus after ablation of the thyroid gland, and reversal of this effect after thyroid dministration (9,5), observations that were the basis for the proposal of thyroidectomy in the treatment of diabetes insipidus in humans (1). Weston et al (16) reported their observations in five hyperthyroid patients that failed to present the anticipated response in antidiuresis and total urinary solute concentration when given betahypophamine, and postulated a decrease in renal tubular response to this hormone as the most likely explanation for this phenomenon.…”

Section: Introductionmentioning

confidence: 99%

Urinary Concentrating Ability in Rats Treated with Thyroxine

Torretti¹,

Marusic²,

Martinez³

1968

Nephron

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The maximal antidiuretic response of thyroxine treated rats fed normal and low sodium diets was studied by analyzing urine volume, sodium, potassium, urea and total solute concentrations in urine, and plasma. Sodium, potassium, ammonia and urea were also measured in kidney cortex, medulla and papilla of rats fed a low sodium diet. The volume of urine collected, Cosm and T^CH₂O were significantly higher in treated than in control rats; whereas no significant difference could be demonstrated in the other parameters studied, except in V × U/P urea, which was significantly higher in thyroxine treated rats, suggesting an increase in GFR. These results support the hypothesis that the increased urine flow observed in thyroxine treated rats is the result of an osmotic diuresis. The conservation of the urinary concentrating ability in spite of the osmotic diuresis may be due either to the fact that the flow attained is not sufficiently high as to limit the urinary concentrating process, or because the concentrating mechanism of these rats is more efficient than that of the controls, a possibility which could be explained by the greater urea excretion of these animals or by an increase of the amount of sodium transported by the ascending limb of the loops of Henle.

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The Effect of Total Thyroidectomy Upon Experimental Diabetes Insipidus in Dogs

Cited by 28 publications

References 0 publications

Thyroid Hormone and the Kidney

Thyroid Hormone and the Kidney

Review of the Literature on the Pituitary Gland (1940 and 1941)

Urinary Concentrating Ability in Rats Treated with Thyroxine

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