The effect of tourniquet application, tranexamic acid, and desmopressin on the procoagulant and fibrinolytic systems during total knee replacement

Ellis, Martin; Fredman, Brian; Zohar, Edna; Ifrach, Nisim; Jedeikin, Robert

doi:10.1016/s0952-8180(01)00319-1

Cited by 76 publications

(82 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Out of the 31 studies (Table 2), two were triple-blind [22,23], 20 were double-blind [8,[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42], three were single-blind [43][44][45], one study was non-blinded [46], and the blinding was unclear in five of the studies [47][48][49][50][51]. In one study, the randomization was performed by a person/ pharmacist/resident who was not involved in the study or the care of patients [35].…”

Section: Resultsmentioning

confidence: 99%

One step closer to sparing total blood loss and transfusion rate in total knee arthroplasty: a meta-analysis of different methods of tranexamic acid administration

Shemshaki

Nourian²,

Nourian

et al. 2015

Arch Orthop Trauma Surg

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

One step closer to sparing total blood loss and transfusion rate in total knee arthroplasty: a meta-analysis of different methods of tranexamic acid administration

Shemshaki

Nourian²,

Nourian

et al. 2015

Arch Orthop Trauma Surg

View full text Add to dashboard Cite

show abstract

“…In previous studies designed to decrease blood loss after TKR, the administration of tranexamic acid (TA) has been associated with significant postoperative allogeneic blood-sparing when compared with control and desmopressin-treated patients (1)(2)(3)(4). However, in these studies, TA was empirically administered via a continuous IV infusion.…”

mentioning

confidence: 99%

The Postoperative Blood-Sparing Efficacy of Oral Versus Intravenous Tranexamic Acid After Total Knee Replacement

Zohar

Ellis²,

Ifrach³

et al. 2004

Anesthesia & Analgesia

Self Cite

123

118

View full text Add to dashboard Cite

To assess the blood-sparing efficacy of tranexamic acid (TA) administered orally or via a variable IV infusion, 80 healthy patients undergoing elective total knee replacement were studied according to a prospective, controlled, randomized, single-blinded study design. Patients were allocated to one of four treatment groups. In group TA-long, 30 min before deflation of the limb tourniquet, an IV bolus dose of TA 15 mg/kg was administered over 30 min. Thereafter, a constant IV infusion of 10 mg . kg(-1) . h(-1) was administered until 12 h after final deflation of the limb tourniquet. In group TA-short, a similar regimen was followed; however, the constant IV infusion was discontinued 2 h after final deflation of the limb tourniquet (time of discharge from the postanesthesia care unit). Thereafter, oral TA 1 g was administered after 6 and 12 h. In group TA-oral, 60 min before surgery an oral dose of TA 1 g was administered. After surgery, a similar dose of TA was administered every 6 h for the next 18 h. In the control group, TA was not administered. At patient discharge, postoperative allogeneic blood administration was significantly more in group Control when compared with each of the three TA treatment groups. Because oral drug administration is simple and does not require specific infusion equipment, the authors suggest that oral TA is a superior blood-sparing strategy compared with IV drug administration.

show abstract

“…With the use of pneumatic tourniquet, the procedures are performed under ischaemic a condition which significantly activates coagulation and fibrinolysis, finally resulting in significant blood loss necessitating post operative allogenic blood transfusion [19] . It is proposed that avoiding the tourniquet use conserves blood; as coagulation process will occur in the bleeding tissues during the operation.…”

Section: Optimizing Operative Techniquementioning

confidence: 99%

“…Many studies have shown that it does not increase predisposition for clotting and thus incidence of thromboembolism is not significantly increased [25] . Tranexemic acid works mainly by interfering with fibrinolysis in the local environment and not systemically [26] . It can be given intravenously, orally or applied topically.…”

Section: Optimizing Operative Techniquementioning

confidence: 99%

Pearls to Prevent Peri-Operative Blood Loss in THR & TKR

Munde¹,

Kamra²,

Jha³

et al. 2017

AIMDR

View full text Add to dashboard Cite

Variations in the arterial pattern of the upper limb are very common as observed in many cadaveric and angiographic studies. Knowledge of variations in the origin and course of the radial artery is important because they are used for many diagnostic procedures as well as vascular and reconstructive surgeries like coronary angiography, percutaneous coronary intervention and coronary artery bypass surgery. During routine dissection in our institute, we observed a case of high origin of the radial artery in a 33 year old male cadaver. It was found to be unilateral; on left side, radial artery

show abstract

The effect of tourniquet application, tranexamic acid, and desmopressin on the procoagulant and fibrinolytic systems during total knee replacement

Cited by 76 publications

References 18 publications

One step closer to sparing total blood loss and transfusion rate in total knee arthroplasty: a meta-analysis of different methods of tranexamic acid administration

One step closer to sparing total blood loss and transfusion rate in total knee arthroplasty: a meta-analysis of different methods of tranexamic acid administration

The Postoperative Blood-Sparing Efficacy of Oral Versus Intravenous Tranexamic Acid After Total Knee Replacement

Pearls to Prevent Peri-Operative Blood Loss in THR & TKR

Contact Info

Product

Resources

About