The effect of tramadol on sneeze‐induced urethral continence reflex through μ‐opioid receptors in the spinal cord in rats

Ashikari, Asuka; Miyazato, Minoru; Kimura, Reiji; Oshiro, Takeshi; Saitoh, Sei–Ichi

doi:10.1002/nau.23518

Cited by 4 publications

(3 citation statements)

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“…These results suggest that glutamate stimulates both bladder and urethral functions. In our previous study, we reported that duloxetine, an inhibitor of norepinephrine‐ and serotonin‐reuptake, 22 and tramadol enhanced the sneeze‐induced urethral continence reflex in normal rats 13 . In the present study, residual urine was increased after tramadol administration in normal rats.…”

Section: Discussionsupporting

confidence: 63%

“…In our previous study, we reported that duloxetine, an inhibitor of norepinephrine-and serotoninreuptake, 22 and tramadol enhanced the sneeze-induced urethral continence reflex in normal rats. 13 In the present study, residual urine was increased after tramadol administration in normal rats. Thus, the activation of norepinephrine, serotonin, and µ-opioid receptor stimulation in the spinal cord can work as storage (i.e., inhibition of the bladder and stimulation of the urethra).…”

Section: Experiments 4: Evaluation Of the Ischemic Damagesupporting

confidence: 53%

“…However, few studies have examined the changes in urethra after CI. Recently, we reported that intravenous administration of tramadol, which has dual effects of µ‐opioid receptor stimulation and inhibition of norepinephrine and serotonin reuptake, enhanced both sympathetic innervated urethral smooth muscle and brain stem‐derived external urethral sphincter continence reflexes in normal rats 13 . Tramadol has an inhibitory effect on DO in CI rats 14 .…”

Section: Introductionmentioning

confidence: 99%

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Influence of cerebral infarction on both bladder and urethral activities and changes after tramadol administration in rats

Nagamine

Kamijo

Ashikari

et al. 2022

Neurourology and Urodynamics

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Aims: We investigated the changes in bladder and urethral function after cerebral infarction (CI) and the influence of tramadol on these functions. Methods: Twenty-eight female Sprague Dawley rats were divided into normal and CI groups. In the awake condition, metabolic cage study and blood pressure were evaluated. Under urethane anesthesia, the intravenous effect of tramadol (0.01-1 mg/kg), which has both µ-opioid receptor stimulation and inhibition of norepinephrine and serotonin reuptake, on continuous cystometry, and simultaneous measurements of bladder and urethral perfusion pressure (UPP) were recorded. Infarcted lesions were examined by staining with triphenyltetrazolium chloride, a marker of mitochondrial enzyme activity. Results: CI rats showed impaired sympathetic activity with Horner's syndrome and lower blood pressure. In metabolic cage study, urinary frequency during the dark phase was increased in CI rats. On bladder activity, in CI rats, the baseline pressure threshold for inducing bladder contractions was significantly lower (p < 0.01), and the intercontraction interval was prolonged after tramadol administration. On urethral activity, the baseline UPP was significantly lower in CI rats than in normal rats and it did not change after tramadol administration. Residual urine rate was significantly increased in normal rats, but not in CI rats. CI rats showed brain infarction including the cortex and hypothalamus, which is a center of the autonomic nervous system.Conclusions: CI-induced ischemic brain damage results in impairment of both bladder and urethral functions, in addition to decreased sympathetic activity. Bladder overactivity after CI can be improved by tramadol; however, urethral activity cannot be improved by it.

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Section: Discussionsupporting

confidence: 63%

Section: Experiments 4: Evaluation Of the Ischemic Damagesupporting

confidence: 53%