The Effect of Tranexamic Acid in Patients with Traumatic Brain Injury

Atia, Samir M; Nabeeh, Mostafa M.; Ahmed, M.; Elsokary, Ahmed

doi:10.21608/ejhm.2021.152975

The Egyptian Journal of Hospital Medicine

2021

DOI: 10.21608/ejhm.2021.152975

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The Effect of Tranexamic Acid in Patients with Traumatic Brain Injury

Samir M Atia¹,

Mostafa M. Nabeeh²,

M. Ahmed³

et al.

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2024

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Cited by 3 publications

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Management of Patients Suffering Acute Traumatic Brain Injuries

Jarrett,

Estes

2024

Critical Care Nursing Quarterly

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The objective of this literature review was to examine and summarize knowledge of best practices for the management of patients suffering traumatic brain injury based on studies using a variety of practices to improve outcomes published 2018 - 2021. From a clinical perspective, when a patient suffers an acute traumatic brain injury, providers and clinicians ask themselves and each other, “What else could we do? What could we have tried to improve the outcome with this patient?” Astute clinicians spend ample time reviewing contemporary studies to improve their patients’ outcomes. This project aimed not to find all studies about a specific treatment, but to review all studies about a topic to evaluate the studies for rigor and results to improve bedside patient care in times of crisis. A quality assessment model was used in four domains: design, bias, synthesis, and dissemination with a Quality Assessment Score assigned for each of the four domains. Ten studies met the rigor of the quality assessment evaluation. The highest ranked studies indicate a common theme of prevention of extension of injury.

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Management of Patients Suffering Acute Traumatic Brain Injuries

Jarrett,

Estes

2024

Critical Care Nursing Quarterly

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Effect of Tranexamic Acid in Patients with Traumatic Brain Injury

Fathey

Ghoneim

Afify

et al. 2021

The Egyptian Journal of Hospital Medicine

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Background: Traumatic brain injury (TBI) is a leading cause of death and disability. Intracranial hemorrhage secondary to TBI is associated with a high risk of coagulopathy and progress of intracranial hemorrhage (ICH). The hemostatic drug tranexamic acid (TXA) with anti-fibrinolytic activity is usually used in patients with trauma to reduce hematoma size. It has been considered a possible therapy to improve the clinical outcome in patients with TBI. Objective: To evaluate the effect of tranexamic acid on the volume of intracranial bleeding in patients with TBI admitted to Critical Care Unit at Menoufia University Hospital. Patients and methods: A prospective randomized placebo-controlled double blinded study in the Critical Care Unit, Menoufia University hospitals, through one year from January 2020 to January 2021. The study was carried out on 40 patients with TBI with Glasgow Coma Scale (GCS) of 4 to 12. They had a computerized tomography (CT) brain scan within 8 hours of injury and in whom there was no indication for immediate surgical intervention. We randomly assigned (1:1) patients to receive tranexamic acid (loading dose 1 g over 10 min then infusion of 1 g over 8 hours) or matching placebo. Results: There was statistically significant reduction in the volume of ICH after 48 hours (p = 0.021) in TXA group than in placebo group. While in placebo group, there was high statistically significant increase in volume of ICH after 48 hours compared to on admission. Moreover, TXA reduced the need of blood transfusion, surgical intervention and the incidence of complications with no evidence of increased risk of thromboembolic events. Conclusion: TXA may reduce the volume of ICH in patients with TBI with no evidence of increased risk of thromboembolic events.

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The efficacy and application of tranexamic acid in emergency medicine: Emergency Medicine Association of Türkiye clinical policy- 2024

Aksel,

Çorbacıoğlu,

İslam

et al. 2024

Turkish Journal of Emergency Medicine

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The clinical policy of the Emergency Medicine Association of Türkiye (EMAT) provides guidance on the use of tranexamic acid (TXA) in emergency settings. TXA, an antifibrinolytic drug, is used to control bleeding by inhibiting plasminogen. Its applications have expanded from hemophilia and severe menstrual bleeding to include various forms of trauma and surgery-related bleeding. Despite its potential benefits, the use of TXA in emergency settings must be carefully evaluated due to its associated risks, including venous thromboembolism. This policy aimed to offer evidence-based recommendations on the indications and contraindications of TXA in different clinical scenarios encountered in the emergency departments. The guidelines were developed using the “Grading of Recommendations, Assessment, Development, and Evaluations” approach, incorporating systematic literature reviews, and expert consensus from the EMAT Research Committee. This document focuses on critical clinical questions regarding the efficacy and safety of TXA in situations such as gastrointestinal bleeding, multitrauma, traumatic brain injury, nontraumatic intracranial hemorrhage, hemoptysis, and epistaxis. By addressing these issues, the policy seeks to assist emergency physicians in making informed decisions about the use of TXA, ultimately aiming to improve the patient outcomes.

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The Effect of Tranexamic Acid in Patients with Traumatic Brain Injury

Cited by 3 publications

References 8 publications

Management of Patients Suffering Acute Traumatic Brain Injuries

Management of Patients Suffering Acute Traumatic Brain Injuries

Effect of Tranexamic Acid in Patients with Traumatic Brain Injury

The efficacy and application of tranexamic acid in emergency medicine: Emergency Medicine Association of Türkiye clinical policy- 2024

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