The effect of tranexamic acid on blood loss in orthognathic surgery: a randomized, placebo-controlled, equivalence study

Jozefowicz, Elsa; Sabourdin, Nada; Lambelin, V.; Lejeune, V.; Delassus, R.; Tavernier, B.

doi:10.1016/j.ijom.2021.08.018

Cited by 13 publications

(15 citation statements)

References 17 publications

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“…The operating time was calculated for each type of orthognathic procedure as the duration from the start time, when the local anesthetic solution was injected, to the end time, when the oral mucosal wound was closed. The intra-operative EBL for each procedure was calculated by weighing the surgical gauze swabs and measuring the contents of the suction bottle (with adjustments made for saline irrigation used) [17]. The hemoglobin level and hematocrit value (packed-cell volume) were obtained on the preoperative day and first postoperative day.…”

Section: Resultsmentioning

confidence: 99%

Assessing the Amount of Blood Losses and the Blood Needed in different types of Orthognathic Surgery (Corrective Jaw Surgery)

Mohammadpour¹

2021

ADOH

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Jaw surgery, also known as orthogenetic (or-thog-NATH-ik) surgery, corrects irregularities of the jawbones and realigns the jaws and teeth to improve the way they work. Making these corrections may also improve your facial appearance. Orthognathic surgeries play a large role They have hospital surgeries for blood loss, factors Numerous such as duration of surgery, surgical method, technique Anesthesia, homeostasis and surgeon skills on blood loss They are effective during surgery. In this study, all the conditions required in such surgeries were investigated. In addition, its results can be effective in the process of dental surgeries.

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Section: Resultsmentioning

confidence: 99%

Assessing the Amount of Blood Losses and the Blood Needed in different types of Orthognathic Surgery (Corrective Jaw Surgery)

Mohammadpour¹

2021

ADOH

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“…TXA can be administrated intravenously or topically irrigated. Eleven intravenous studies [18][19][20][21][22][23][24]26,[28][29][30] and 2 topical studies 25,27 were included in this study. Stratified analysis showed an effect of different modes of administration on orthognathic surgical blood loss.…”

Section: Discussionmentioning

confidence: 99%

“…Details of the anesthetic method were reported in all included studies. [17][18][19][20][21][22][23][24][25][26][27][28][29]…”

Section: Study Characteristicsmentioning

confidence: 99%

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The Efficacy of Tranexamic Acid in Craniomaxillofacial Surgery: A Systematic Review of Randomized Controlled Trials

Zhao,

Luo,

Guo

et al. 2023

Journal of Craniofacial Surgery

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This study aimed to evaluate the use of tranexamic acid in craniomaxillofacial surgery by meta-analysis. A comprehensive search was performed for randomized controlled trials (RCTs) mainly in 3 electronic databases (PubMed, EMBASE, and Cochrane Library) before August 2022. We collected and managed data for weighted mean difference of intraoperative blood loss, transfusion requirement, and operation time for the study. A total of 13 randomized controlled trials were included in the analysis. Compared with the control group, the tranexamic acid group showed a reduction in intraoperative blood loss of 198.67 ml (95% CI: −258.84 to −138.50 ml, P<0.00001), with blood transfusion requirement decreased by 7.77 ml/kg (95% CI: −10.80 to −4.73, P<0.0001) and less operation time (weighted mean difference= −10.39 min; 95% CI: −16.49 to −4.30 min, P=0.0008).

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“…Fibrinolysis in the oral cavity seems to contribute to increased blood loss. 5 TXA may be considered as a prophylactic hemostatic intervention in major orthognathic surgery because only 25% of oromaxillary surgeons currently use TXA. 3 FUNDING INFORMATION Not applicable.…”

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confidence: 99%

In response: Not all acute normovolemic hemodilutions are created equal

Zhong,

Butt,

Dautel

et al. 2023

Transfusion

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We read with great interest the work by Li et al. 1 The authors hypothesized that red blood cell (RBC) transfusions in orthognathic surgery could be reduced by acute normovolemic hemodilution (ANH); 187 patients were randomly assigned to conventional management or ANH. There is a renewed interest in ANH as part of perioperative multimodal blood conservation strategy. Their study is a welcome addition to the ANH literature; however, further discussion and comment are warranted for the study design and indication of ANH.

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The effect of tranexamic acid on blood loss in orthognathic surgery: a randomized, placebo-controlled, equivalence study

Cited by 13 publications

References 17 publications

Assessing the Amount of Blood Losses and the Blood Needed in different types of Orthognathic Surgery (Corrective Jaw Surgery)

Assessing the Amount of Blood Losses and the Blood Needed in different types of Orthognathic Surgery (Corrective Jaw Surgery)

The Efficacy of Tranexamic Acid in Craniomaxillofacial Surgery: A Systematic Review of Randomized Controlled Trials

In response: Not all acute normovolemic hemodilutions are created equal

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