The effect of transcutaneous vagus nerve stimulation on pain perception – An experimental study

Busch, Volker; Zeman, Florian; Heckel, A.; Menne, Felix; Ellrich, Jens; Eichhammer, Peter

doi:10.1016/j.brs.2012.04.006

Cited by 207 publications

(196 citation statements)

References 44 publications

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“…The afferents of the vagus nerve are usually able to inhibit the activity of the second order nociceptive neurons of the spinal cord, through spinotalamic and spinoreticular tracts and in the trigeminal nuclei [31]. The vagus nerve has the ability to transmit painful information, particularly visceral pain, to the supraspinal centers [17].…”

Section: New Hypotheses and Considerations On Chronic Pain And Psychimentioning

confidence: 99%

“…The vagus nerve has the ability to transmit painful information, particularly visceral pain, to the supraspinal centers [17]. This can happen thanks to a retrograde transport of biochemicals through the nerve [31]. The same nerve collaborates to the formation and maintenance of the central pain memory, modulating inhibitory descendant pathways to nociceptive areas in the spinal cord [31].…”

Section: New Hypotheses and Considerations On Chronic Pain And Psychimentioning

confidence: 99%

“…This can happen thanks to a retrograde transport of biochemicals through the nerve [31]. The same nerve collaborates to the formation and maintenance of the central pain memory, modulating inhibitory descendant pathways to nociceptive areas in the spinal cord [31]. Complete information are not available on these ascendant mechanisms (probably involving NTS, parabrachial nuclei, periaqueductal grey area, hypothalamus, limbic area, magnum raphe, locus ceruleus), as well as on descendant ones, but we can state that the vagal tone has an important influence on pain perception [32].…”

Section: New Hypotheses and Considerations On Chronic Pain And Psychimentioning

confidence: 99%

See 2 more Smart Citations

Depression, anxiety and chronic pain in patients with chronic obstructive pulmonary disease: the influence of breath

Bordoni

Marelli²,

Bruno

et al. 2017

Monaldi Arch Chest Dis

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Chronic obstructive pulmonary disease (COPD) is a major public health problems, causing significant mortality and morbidity in the world. It is a complex and progressive disease, characterized by chronic inflammation and dysfunction of the respiratory airways. The article reviews the available information on the potential role of the diaphragm in this disease. The purpose is to identify a potential correlation between symptoms such as depression, anxiety and chronic pain, frequently observed in COPD, with the activity of the diaphragm. The morphology and metabolism of the diaphragm are usually modified in the presence of COPD: a correlation between this symptoms and a pathological adaptation of breathing can be hypothesized. The management of these conditions should always be multidisciplinary, in order to have a global vision of the patient.

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Section: New Hypotheses and Considerations On Chronic Pain And Psychimentioning

confidence: 99%

Section: New Hypotheses and Considerations On Chronic Pain And Psychimentioning

confidence: 99%

Section: New Hypotheses and Considerations On Chronic Pain And Psychimentioning

confidence: 99%

See 1 more Smart Citation

Depression, anxiety and chronic pain in patients with chronic obstructive pulmonary disease: the influence of breath

Bordoni

Marelli²,

Bruno

et al. 2017

Monaldi Arch Chest Dis

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“…In recent years the major sites of interest for delivering electrical stimulation to the ABVN have been the inner surface of the tragus (Busch et al, 2013;Clancy et al, 2014;Kraus et al, 2013;Stavrakis et al, 2015;Weise et al, 2015;Zhou et al, 2016), the concha (Ay et al, 2015b;Fang et al, 2015;He et al, 2013b;Liu et al, 2013), and the cymba concha (Frangos et al, 2015;Kreuzer et al, 2014). In parallel with these ear studies, a method said to allow non-invasive cervical vagus nerve stimulation through the skin of the neck has also been developed and is under investigation in patients with cluster headache (Nesbitt et al, 2015) and migraine (Barbanti et al, 2015).…”

Section: Cardiac Effects Of Tvnsmentioning

confidence: 99%

The strange case of the ear and the heart: The auricular vagus nerve and its influence on cardiac control

Murray

Atkinson

Mahadi

et al. 2016

Autonomic Neuroscience

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The human ear seems an unlikely candidate for therapies aimed at improving cardiac function, but the ear and the heart share a common connection: the vagus nerve. In recent years there has been increasing interest in the auricular branch of the vagus nerve (ABVN), a unique cutaneous subdivision of the vagus distributed to the external ear. Non-invasive electrical stimulation of this nerve through the skin may offer a simple, cost-effective alternative to the established method of vagus nerve stimulation (VNS), which requires a surgical procedure and has generated mixed results in a number of clinical trials for heart failure. This review discusses the available evidence in support of modulating cardiac activity using this strange auricular nerve.

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“…There is a fast growing interest in the transcutaneous vagal nerve stimulation (t-VNS), first proposed by Ventureira, 1 which is a promising treatment of refractory epilepsy, pain, depression and other neuropsychiatric diseases [2][3][4][5] and special stimulating devices are constructed for its application. 6 This method represents a noninvasive, safer and cheaper alternative of the cervical vagal nerve stimulation, studies that started in 1938 with cat experiments of Bailey and Bremmer 7 and established the vagal nerve as an important route in the central nervous system, which can be used for brain neuromodulation by the nonspecific stimulation information carried by vagal afferents.…”

Section: Introductionmentioning

confidence: 99%

Effects of Acute Transcutaneous Vagal Stimulation on the EEG Power Maps, EEG Sources Distribution and Steadiness of Quiet and Sensory-conflicted Stance

Dimitrov¹,

Gatev²

2015

Posture, Balance and the Brain

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Transcutaneous vagal stimulation (t-VNS) is a prospective method as a cheap and noninvasive alternative of surgical cervical vagal stimulation widely used for treatment of refractory epilepsy, depression etc. Data on its application in healthy people are scarce. A lot of problems concerning the acting mechanisms and cortical representation are unsolved. We did acute t-VNS and studied the standing balance steadiness, EEG absolute power maps and sources distribution. We found improvement of the steadiness of standing with eyes open (EO), but no changes in the eyes closed (EC) series.In EO Delta and Theta power in the right frontal area increased and Beta and Gamma bands of EEG absolute power in the left and right parieto-occipital areas also increased, which sustained for 20 min after t-VNS. The distribution of maxima of EEG sources revealed by LORETA showed shifts to the right and occipital direction after t-VNS, while 20 min later the maxima were symmetrically located, but the occipital shift was preserved. Pre-treatment sources during EO were in multisensory fields: the inferior parietal lobule, superior temporal gyrus and precuneus, after t-VNS they were in the inferior parietal lobule, middle temporal gyrus, right posterior cingulate, precuneus, cuneus and right lingual gyrus. After 20 min the maxima of EEG sources were in the inferior parietal lobule, superior and middle temporal gyrus and left insula.In EC following t-VNS Delta power first decreased in the right frontal and occipital areas and in the central parietal area, 20 min later it was greater than in pre-treatment series in these areas. The results showed an increase of EEG absolute power in the Beta and Gamma ranges mainly in the occipital area and less expressed in the postero-parietal one. The increase was more expressed for Gamma than Beta band similarly to the EO series. However, this increase in Beta and Gamma EEG power in EC was mainly located in the left side of the cortex. After t-VNS we observed shifts of electrical sources locations to the occipital and top parts of the brain. Unlike, during the EO series we observed shift to the lower frequencies in the absolute power cortical maps. After 20 min a tendency to return to the pre-treatment coordinates occurred, the power, increased immediately after t-VNS, dropped much lower than its initial value. The locations of maxima of electrical sources during EC before t-VNS were in the middle and inferior frontal gyrus, right inferior parietal lobule, cingulate and precuneus. Immediately after t- Bozhidar Dimitrov and Plamen Gatev 46VNS these locations were in the superior temporal gyrus, middle temporal gyrus, precuneus, cuneus and left inferior parietal lobule. After 20 min the locations of the maxima of electrical sources were in the anterior cingulate cortex, medial frontal gyrus, precuneus, cuneus and lingual gyrus.Our results show that cortical processing of the t-VNS information and its effect on standing balance are quite different during standing with EO compared to standing with...

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The effect of transcutaneous vagus nerve stimulation on pain perception – An experimental study

Cited by 207 publications

References 44 publications

Depression, anxiety and chronic pain in patients with chronic obstructive pulmonary disease: the influence of breath

Depression, anxiety and chronic pain in patients with chronic obstructive pulmonary disease: the influence of breath

The strange case of the ear and the heart: The auricular vagus nerve and its influence on cardiac control

Effects of Acute Transcutaneous Vagal Stimulation on the EEG Power Maps, EEG Sources Distribution and Steadiness of Quiet and Sensory-conflicted Stance

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