The effect of Translationally Controlled Tumour Protein (TCTP) on programmed cell death in plants

Hoepflinger, Marion C.; Reitsamer, Johannes; Geretschlaeger, Anja; Mehlmer, Norbert; Tenhaken, Raimund

doi:10.1186/1471-2229-13-135

Cited by 53 publications

(44 citation statements)

References 41 publications

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“…TCTP overexpression also promoted biomass production and it protected plants against salt and osmotic stress. These observations are also consistent with an earlier study that demonstrated the ability of Arabidopsis thaliana TCTP to protect tobacco leafs against induction of programmed cell death (Hoepflinger et al 2013). …”

Section: Note Added In Proofsupporting

confidence: 93%

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Bommer

2017

Results and Problems in Cell Differentiation

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The Translational Controlled Tumour Protein TCTP (gene symbol TPT1, also called P21, P23, Q23, fortilin or histamine-releasing factor, HRF) is a highly conserved protein present in essentially all eukaryotic organisms and involved in many fundamental cell biological and disease processes. It was first discovered about 35 years ago, and it took an extended period of time for its multiple functions to be revealed, and even today we do not yet fully understand all the details. Having witnessed most of this history, in this chapter, I give a brief overview and review the current knowledge on the structure, biological functions, disease involvements and cellular regulation of this protein. TCTP is able to interact with a large number of other proteins and is therefore involved in many core cell biological processes, predominantly in the response to cellular stresses, such as oxidative stress, heat shock, genotoxic stress, imbalance of ion metabolism as well as other conditions. Mechanistically, TCTP acts as an anti-apoptotic protein, and it is involved in DNA-damage repair and in cellular autophagy. Thus, broadly speaking, TCTP can be considered a cytoprotective protein. In addition, TCTP facilitates cell division through stabilising the mitotic spindle and cell growth through modulating growth signalling pathways and through its interaction with the proteosynthetic machinery of the cell. Due to its activities, both as an anti-apoptotic protein and in promoting cell growth and division, TCTP is also essential in the early development of both animals and plants. Apart from its involvement in various biological processes at the cellular level, TCTP can also act as an extracellular protein and as such has been involved in modulating whole-body defence processes, namely in the mammalian immune system. Extracellular TCTP, typically in its dimerised form, is able to induce the release of cytokines and other signalling molecules from various types of immune cells. There are also several examples, where TCTP was shown to be involved in antiviral/antibacterial defence in lower animals. In plants, the protein appears to have a protective effect against phytotoxic stresses, such as flooding, draught, too high or low temperature, salt stress or exposure to heavy metals. The finding for the latter stress condition is corroborated by earlier reports that TCTP levels are considerably up-regulated upon exposure of earthworms to high levels of heavy metals. Given the involvement of TCTP in many biological processes aimed at maintaining cellular or whole-body homeostasis, it is not surprising that dysregulation of TCTP levels may promote a range of disease processes, foremost cancer. Indeed a large body of evidence now supports a role of TCTP in at least the most predominant types of human cancers. Typically, this can be ascribed to both the anti-apoptotic activity of the protein and to its function in promoting cell growth and division. However, TCTP also appears to be involved in the later stages of cancer progression, such ...

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Section: Note Added In Proofsupporting

confidence: 93%

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Bommer

2017

Results and Problems in Cell Differentiation

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“…Many studies carried out showed that TCTP took part in various cellular processes (e.g. cell growth, cell cycle progression, microtubule organization, and protection against apoptosis) (Hoepflinger et al 2013). So we designed a series of experiments to demonstrate our assumption.…”

Section: Discussionmentioning

confidence: 94%

Expression and clinical role of TCTP in epithelial ovarian cancer

et al. 2015

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The aim of this study is to investigate the potential role and prognostic significance of translationally controlled tumor protein (TCTP) in human epithelial ovarian cancer (EOC). Western blot was used to evaluate the expression of TCTP in eight fresh EOC tissues. Immunohistochemistry was performed on formalin-fixed paraffin-embedded sections of 119 cases of ovarian cancers. Kaplan-Meier method indicated the relation between TCTP and EOC patients' overall survival rate. Starvation and re-feeding was used to assess cell cycle. Knocking down of TCTP and CCK8 assay showed the role of TCTP in HO8910 cell cycle. We found that TCTP was overexpressed in carcinoma tissues compared with normal tissues. Immunohistochemistry revealed that TCTP expression was significantly associated with clinicopathologic variables. Kaplan-Meier analysis revealed that high TCTP expression was significantly related to poor prognosis of the patients. Starvation and re-feeding suggested TCTP played a critical role in HO8910 cell proliferation. Interference of TCTP and CCK8 assay showed that the TCTP-siRNA treated HO8910 cells grew more slowly than the control group. CCK-8 assays and terminal-deoxynucleoitidyl transferase mediated nick end labeling assays were also performed to demonstrate the cisplatin could inhibit the survival of HO8910 cells and promote their apoptosis. All the experiments we have done showed that TCTP could promote the progression of EOC and reduce the sensitiveness of HO8910 cells to cisplatin.

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“…TCTP is related to interact with a large number of different proteins, however, its binding partners are not well conserved in eukaryotes, and therefore its alternative functions may differ from an organism to another (Wu et al, 2015). It was first identified in mice (Yenofsky et al, 1982) and humans (Gross et al, 1989), and then in other organisms such as yeasts, invertebrates and plants (Bonnet et al, 2000;Gnanasekar et al, 2002;Rao et al, 2002;Hoepflinger et al, 2013). TCTP has been identified in the secretions of animal-parasitic nematodes , and of Meloidogyne enterolobii, a plant parasitic nematode (Zhuo et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Research Article In silico modeling and characterization of phytoparasitic nematodes translationally-controlled tumor proteins.

Filho¹,

Menezes²,

Martins³

2017

Genet. Mol. Res.

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ABSTRACT. Plant parasitic nematodes infect a wide range of hosts representing the largest source of biotic stress experienced by plants. Meloidogyne genus comprises the most important parasitic nematodes, also known as root-knot nematodes. These parasitic organisms obtain nutrients to support their development through complex interactions with their hosts. The translationally-controlled tumor protein (TCTP) is widely expressed in eukaryotic organisms, and is related to a great diversity of biological processes such as calcium binding, cell proliferation and growth, pluripotency, regulation of apoptosis, microtubules stabilization, and histamine release. TCTP has been identified in the secretions of plant-parasitic nematodes, and may play a role in suppressing the plant immunity and programmed cell, hence promoting nematode parasitism. Our results revealed a high conservation of the evaluated protein sequences and little variation in their physicochemical characteristics, such as isoelectric points and hidropathicity. Phylogenetic analysis also revealed the presence of three main groups of TCTPs, corresponding to plant parasitic, animal parasitic and freeliving nematodes. Six plant parasitic TCTPs tertiary structure models were generated by homology modeling. The constructed models were highly similar and most of the structural variations occurred outside the characterized functional domains. To our knowledge, these are the first theoretical models of plant parasitic nematodes TCTPs and these results may provide a theoretical basis for future studies of host plant resistance to nematode infection.

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The effect of Translationally Controlled Tumour Protein (TCTP) on programmed cell death in plants

Cited by 53 publications

References 41 publications

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Expression and clinical role of TCTP in epithelial ovarian cancer

Research Article In silico modeling and characterization of phytoparasitic nematodes translationally-controlled tumor proteins.

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