The effect of treatment on monocyte and lymphocyte cytokine release in patients with aldosteronoma

Krysiak, Robert

doi:10.1038/hr.2011.142

Cited by 11 publications

(4 citation statements)

References 10 publications

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“…Of clinical importance, patients with aldosterone-producing adenomas and resistant arterial hypertension exhibit high levels of IL-1␤ and other cytokines (IL-6 and TNF-␣), and MR blockade with spironolactone or eplerenone, as well as adrenalectomy, decreases cytokine levels to levels seen in healthy control subjects (64). Our study showed that leukocytes from patients with hyperaldosteronism exhibit NLRP3 inflam-H994 masome activation and increased serum IL-1␤ levels compared with healthy human volunteers (20).…”

Section: Role Of Immune Cells In Aldosterone-induced Vascular Damagementioning

confidence: 55%

New roles of aldosterone and mineralocorticoid receptors in cardiovascular disease: translational and sex-specific effects

Davel

Jaffe

Tostes

et al. 2018

American Journal of Physiology-Heart and Circulatory Physiology

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Recent advances in the field of mineralocorticoid receptor (MR) and its ligand aldosterone expanded the role of this hormone and its receptor far beyond their initial function as a regulator of Na and K homeostasis in epithelial cells. The symposium "New Roles of Aldosterone and Mineralocorticoid Receptors in Cardiovascular Disease: Translational and Sex-Specific Effects" presented at the 38th World Congress of the International Union of Physiological Sciences (Rio de Janeiro, Brazil) highlighted the contribution of extrarenal MRs to cardiovascular disease. This symposium showcased how MRs expressed in endothelial, vascular smooth muscle, and immune cells plays a critical role in the development of vascular disease associated with aging, obesity, and chronic aldosterone stimulation and demonstrated that MR antagonism prevents the acute renal dysfunction and tubular injury induced by ischemia-reperfusion injury. It was also shown that the adipocyte-derived hormone leptin is a new direct regulator of aldosterone secretion and that leptin-mediated aldosterone production is a major contributor to obesity-associated hypertension in women. Sex differences in the role of aldosterone and of endothelial MR in the cardiovascular outcomes of obesity were highlighted. This review summarizes these important emerging concepts regarding the contribution of aldosterone and cell-specific MR to cardiovascular disease in male and female subjects and further supports sex-specific benefits of MR antagonist drugs to be tested in additional populations.

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Section: Role Of Immune Cells In Aldosterone-induced Vascular Damagementioning

confidence: 55%

New roles of aldosterone and mineralocorticoid receptors in cardiovascular disease: translational and sex-specific effects

Davel

Jaffe

Tostes

et al. 2018

American Journal of Physiology-Heart and Circulatory Physiology

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“…On the other hand, proinflammatory cytokines could also play an important role. Krysiak and Okopien reported that higher levels of tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), and interleukin 1 beta (IL-1β) from monocytes/macrophages and of interleukin 2 (IL-2), interferon gamma (IFN-γ), and TNF-α from lymphocytes were found in patients with APA than in patients with EH [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Risk of sepsis in patients with primary aldosteronism

Chan

Chen

et al. 2018

Crit Care

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BackgroundThe interaction between hyperaldosteronism and immune dysfunction has been reported and glucocorticoid co-secretion is frequently found in primary aldosteronism (PA). The aforementioned conditions raise the possibility of the infection risk; however, clinical episodes of sepsis have not been reported in PA.MethodsUsing Taiwan’s National Health Insurance Research Database between 1997 and 2009, we identified PA and aldosterone-producing adenoma (APA) matched with essential hypertension (EH) at a 1:1 ratio by propensity scores. The incidences of sepsis and mortality after the index date were evaluated, and the risk factors of outcomes were identified using adjusted Cox proportional hazards models and taking mortality as a competing risk.ResultsWe enrolled 2448 patients with PA (male, 46.08%; mean age, 48.4 years). There were 875 patients who could be ascertained as APA. Taking mortality as the competing risk, APA patients had a lower incidence of sepsis than their matched EH patients (hazard ratio (HR) 0.29; P < 0.001) after target treatments. Patients receiving adrenalectomy showed a benefit of decreasing the risk of sepsis (PA vs EH, HR 0.14, P = 0.001; APA vs EH, HR 0.16, P = 0.003), but mineralocorticoid receptor antagonist treatment may differ. Compared with matched control cohorts, patients with APA had a lower risk of all-cause mortality (PA, adjusted HR 0.84, P = 0.050; APA, adjusted HR 0.31, P < 0.001) after target treatments.ConclusionsOur study demonstrated that patients with PA/APA who underwent adrenalectomy could attenuate the risk of sepsis compared with their matched EH patients. We further found that APA patients with target treatments could decrease all-cause mortality compared with EH patients.Electronic supplementary materialThe online version of this article (10.1186/s13054-018-2239-y) contains supplementary material, which is available to authorized users.

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“…Krysiak et al. reported that the levels of tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), and interleukin 1 beta (IL-1β) from monocytes/macrophage and interleukin 2 (IL-2), interferon-gamma (IFN-γ), and TNF-α from lymphocytes were much higher in patients with aldosteronoma than those in EH individuals, suggesting an active T-cell immunity in APA patients ( 38 ). Additionally, it has been known that most of the APA patients harbor KCNJ5 somatic mutations, especially in Asian populations ( 39 , 40 ).…”

Section: Discussionmentioning

confidence: 99%

Divergent Characteristics of T-Cell Receptor Repertoire Between Essential Hypertension and Aldosterone-Producing Adenoma

Chang

Peng²,

Chan³

et al. 2022

Front. Immunol.

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Aldosterone-producing adenoma (APA) is a benign adrenal tumor that results in persistent hyperaldosteronism. As one major subtype of primary aldosteronism, APA leads to secondary hypertension that is associated with immune dysregulation. However, how the adaptive immune system, particularly the T-cell population, is altered in APA patients remains largely unknown. Here, we performed TCR sequencing to characterize the TCR repertoire between two age-matched groups of patients: one with APA and the other one with essential hypertension (EH). Strikingly, we found a significant reduction of TCR repertoire diversity in the APA group. Analyses on TCR clustering and antigen annotation further showed that the APA group possessed lower diversity in TCR clonotypes with non-common antigen-specific features, compared with the EH group. In addition, our results indicated that the strength of correlation between generation probabilities and frequencies of TCR clonotypes was significantly higher in the APA group than that in the EH group. Finally, we observed that clinical features, including plasma aldosterone level, aldosterone–renin ratio, and blood sodium level, were positively associated with the strength of correlation between generation and abundance of TCR clonotypes in the APA group. Our findings unveiled the correlation between T-cell immune repertoire and APA, suggesting a critical role of such adrenal adenoma in the T-cell immunity of patients with hypertension.

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The effect of treatment on monocyte and lymphocyte cytokine release in patients with aldosteronoma

Cited by 11 publications

References 10 publications

New roles of aldosterone and mineralocorticoid receptors in cardiovascular disease: translational and sex-specific effects

New roles of aldosterone and mineralocorticoid receptors in cardiovascular disease: translational and sex-specific effects

Risk of sepsis in patients with primary aldosteronism

Divergent Characteristics of T-Cell Receptor Repertoire Between Essential Hypertension and Aldosterone-Producing Adenoma

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