The effect of tri-iodothyronine in combination with imipramine on [3H]-cyclic AMP production in slices of rat cerebral cortex

Frazer, Alan; Pandey, Ghanshyam N.; Mendels, J.; Neeley, Scott P.; Kane, Michael J.; Hess, Marilyn E.

doi:10.1016/0028-3908(74)90063-x

Cited by 92 publications

(16 citation statements)

References 38 publications

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“…Although the major emphasis of the work of Schmidt and Schultz ( 1985) is on cortical cyclic AMP generating systems, and not the beta-adrenoceptor per se, their finding that T, or T 4 down-regulates cortical beta-receptors in some strains of rats seems discordant with the present report and that of Perumal et al (1984), as well as with earlier studies by Frazer et al (1974) and Gross et al (1980b) on the effects of thyroid status on the cortical adenylate cyclase system. Nevertheless, in the light of theories that advocate down-regulation ofbeta-adrenergic receptorcoupled adenylate cyclase systems as the mechanism of action of antidepressant drugs, their findings are consistent with the clinical observation that small doses of thyroid hormones can potentiate the action of antidepressant drugs.…”

Section: Discussionsupporting

confidence: 66%

The effects of thyroid state on beta-adrenergic and serotonergic receptors in rat brain

Mason

Bondy

Nemeroff

et al. 1987

Psychoneuroendocrinology

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Section: Discussionsupporting

confidence: 66%

The effects of thyroid state on beta-adrenergic and serotonergic receptors in rat brain

Mason

Bondy

Nemeroff

et al. 1987

Psychoneuroendocrinology

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“…12,16,17 We have found that those antidepressants that cause this effect do so most robustly in certain amygdaloidal nuclei, such as its basolateral nucleus. 18 Moreover, down-regulation of ␤ 1 adrenoceptors is only produced by drugs that acutely enhance noradrenergic function; SSRIs, for example, do not produce this effect ( Figure 2).…”

Section: Delayed Pharmacological Effects Of Antidepressantsmentioning

confidence: 99%

Delayed pharmacological effects of antidepressants

2002

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Although antidepressants may not be primary mood stabilizers, they are efficacious in the prophylaxis of recurrent depressive illnesses, as well as in the treatment of acute episodes. Pharmacological effects that may contribute to the prophylactic effects of these drugs are not understood. Studies have been carried out in which antidepressants have been given to laboratory animals, such as rats, for periods of up to 3-4 weeks. Data obtained in such studies are thought to be important for their beneficial effects in depressive episodes, but also may be relevant to their prophylactic effects. Results are presented showing that when selective inhibitors of serotonin or norepinephrine uptake are given for such time periods, they still produce selective effects on serotonergic or noradrenergic parameters. For example, longterm administration of selective norepinephrine reuptake inhibitors causes a down-regulation of ␤ 1 adrenoceptors. Selective serotonin reuptake inhibitors do not produce this effect. Longterm administration of selective serotonin reuptake inhibitors causes down-regulation of the serotonin transporter, but not the norepinephrine transporter. In contrast, selective norepinephrine reuptake inhibitors down-regulate the norepinephrine transporter but not the serotonin transporter. Substantial loss of serotonin transporter binding sites takes 15 days to occur and is accompanied by a marked reduction of serotonin transporter function in vivo. Molecular Psychiatry (2002) 7, S23-S28.

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“…Down-regulation of J3-adrenergic receptors after long-term administration of tricyclic antidepressant drugs (Frazer et al 1974;Banerjee et al 1977) and elec troconvulsive shock (Bergstrom and Kellar, 1977) may depend not only on the input from NE neurons (Wolfe et al 1978), but also on 5-HT innervation (Brunello et al 1982;Janowsky et al 1982). Since selective lesions 5-HT and NE Uptake Inhibitor 31 of 5-HT terminals with 5,7-dihydroxytryptamine, but not merely inhibition of 5-HT synthesis by p-chloro phenylalanine, prevent down-regulation of J3-adren ergic receptors by antidepressant treatments, a factor present in 5-HT terminals other than 5-HT itself may be involved (Nimgaonkar et al 1985).…”

Section: Food Intake Studiesmentioning

confidence: 99%

LY248686, A New Inhibitor of Serotonin and Norepinephrine Uptake

Wong

Bymaster

Mayle

et al. 1993

Neuropsychopharmacol

210

136

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LY248686 is an inhibitor of serotonin (S-hydroxytryptamine; 5-HT) and norepinephrine (NE) uptake in synaptosomal preparations of hypothalamus and cerebral cortex, and 5-HT uptake in human blood platelets, with inhibitor constants near nanomolar concentrations. Upon administration to rats 1 hour before sacrifi ce, LY248686 caused dose-dependent and parallel decreases of 5-HT and NE uptake in hypothalamus homogenates ex vivo. LY248686 is a positive enantiomer and was slightly more potent than its negative isomer, LY248685, as an inhibitor of 5-HT uptake. Both isomers were only weak inhibitors of dopamine (DA) uptake in striatal synaptosomes. The inhibitory effects on 5-HT and NE uptake after a single administration of LY248686 KEY WORDS: Uptake; Inhibitor; Serotonin; Norepineph rineThe extent of inhibition of serotonin (5-hydroxytrypta mine; 5-HT) and norepinephrine (NE) uptake by the tricyclic tertiary amine-containing antidepressant drugs depends on their relative degrees of metabolic N-demethylation. Amitriptyline, an inhibitor of 5-HT and NE uptake in nerve-ending preparations (synap tosomes), is converted in vivo to nortriptyline, a po tent and selective inhibitor of NE uptake, while imipra mine, a selective inhibitor of 5-HT uptake, is converted to desipramine, another potent and selective inhibitor

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The effect of tri-iodothyronine in combination with imipramine on [3H]-cyclic AMP production in slices of rat cerebral cortex

Cited by 92 publications

References 38 publications

The effects of thyroid state on beta-adrenergic and serotonergic receptors in rat brain

The effects of thyroid state on beta-adrenergic and serotonergic receptors in rat brain

Delayed pharmacological effects of antidepressants

LY248686, A New Inhibitor of Serotonin and Norepinephrine Uptake

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