The effect of triclosan-coated sutures in wound healing. A double blind randomised prospective pilot study

PURPOSE Previously published guidelines are available that provide comprehensive recommendations for detecting and preventing healthcare-associated infections (HAIs). The intent of this document is to highlight practical recommendations in a concise format designed to assist acute care hospitals in implementing and prioritizing their surgical site infection (SSI) prevention efforts. This document updates “Strategies to Prevent Surgical Site Infections in Acute Care Hospitals,”1 published in 2008. This expert guidance document is sponsored by the Society for Healthcare Epidemiology of America (SHEA) and is the product of a collaborative effort led by SHEA, the Infectious Diseases Society of America (IDSA), the American Hospital Association (AHA), the Association for Professionals in Infection Control and Epidemiology (APIC), and The Joint Commission, with major contributions from representatives of a number of organizations and societies with content expertise. The list of endorsing and supporting organizations is presented in the introduction to the 2014 updates.2

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“…166 In addition, one small study raised concern about higher rates of wound dehiscence while using these sutures. 167 …”

Section: Section 4 : Recommended Strategies For Ssi Preventionmentioning

confidence: 99%

Strategies to Prevent Surgical Site Infections in Acute Care Hospitals: 2014 Update

Anderson

Podgorny

Berríos-Torres

et al. 2014

Infect. Control Hosp. Epidemiol.

824

447

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“…The resultant herbal soap formulations also demonstrated suitable pH and foam stability properties, and could therefore serve as a substitute for soaps containing synthetic antiseptic agents especially triclosan, which has become controversial because of its untoward effects in humans (Deliaert et al, 2008) and the environment (Chalew and Halden, 2009). …”

Section: Discussionmentioning

confidence: 99%

“…Studies on triclosan, an antimicrobial agent popularly used in antiseptic toiletries, have raised questions on its possible hazard to human health (Deliaert et al, 2008;Zorrilla et al, 2009) and its contribution to development of antibiotic-resistant germs in the environment (Chalew and Halden, 2009). In the United States of America, the Food and Drug Administration (FDA) has announced the prohibition of sale of "consumer antiseptic washes" containing triclosan effective September, 2017(FDA, 2016.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical properties and antimicrobial activities of soap formulations containing Senna alata and Eugenia uniflora leaf preparations

Ojo¹,

Ezekiel²,

Doyinsola³

et al. 2017

J. Med. Plants Res.

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Senna alata leaf extract demonstrates antimicrobial properties that promise utility for treatment of topical infections. Its combination with similarly bioactive Eugenia uniflora leaf extract in soap formulation could enhance anti-infective efficacy. The objective of this study was to develop potent antiseptic herbal soap formulations (HSFs) with the combined leaf extracts of the two plants. A soap base having suitable physicochemical properties (emolliency, foaming potential, and pH) was selected from a series of trial formulations produced from basic soap ingredients. Into this was incorporated three different preparations (namely, the methanolic fresh leaf extract (FLE), methanolic dry leaf extract (DLE), and the pulverized dry leaf sample (DLP) of S. alata and E. uniflora, respectively, singly or combined in 1:1 (w/w) ratio; to produce HSFs containing 5, 9, or 11%w/w concentrations of the leaf preparations. The physicochemical properties of the HSFs were determined as well as their antimicrobial activities by hole-in-plate agar diffusion assay against Staphylococcus aureus, Bacillus subtilis and Candida albicans. The selected soap base exhibited highest-rank emolliency, satisfactory stable froth production, and pH value. The physicochemical properties of the resulting HSFs were similar. The HSFs containing combinations of the DLEs at 9 and 11% concentrations demonstrated antimicrobial activities against S. aureus and C. albicans comparable (p>0.05) to those of the comparator commercial antiseptic soap containing 0.30% triclosan. B. subtilis was less sensitive (p<0.05) to the HSFs. On the other hand, when used singly, the DLEs as well as the FLEs and DLPs were significantly less potent (p<0.05) than the DLEs combined in the soap formulations. In conclusion, the HSFs containing S. alata and E. uniflora DLEs combined (1:1 w/w) at 9 and 11% concentrations exhibited satisfactory physicochemical properties and potent antimicrobial activities similar to the comparator commercial antiseptic soap employed in the study.

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“…16 In another study, conducted on breast cancer patients, TC coated sutures displayed increased wound dehiscence rate when compared with uncoated. 17 Furthermore, apart from the prevention of infection, TC coated sutures inhibits the bacterial colonization, alters the cytokine levels which may prelude to accelerated wound healing. 11 In our study, the based on the Southampton wound scoring system there was no significant improvement in the wound healing in patients treated with TC coated sutures as that of the conventional sutures.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of antimicrobial sutures in reducing surgical site infection during hernia surgery: a comparative study

Karikazi¹,

Kolhar²,

Shirbur³

2016

Int Surg J

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The effect of triclosan-coated sutures in wound healing. A double blind randomised prospective pilot study

Cited by 65 publications

References 7 publications

Strategies to Prevent Surgical Site Infections in Acute Care Hospitals: 2014 Update

Strategies to Prevent Surgical Site Infections in Acute Care Hospitals: 2014 Update

Physicochemical properties and antimicrobial activities of soap formulations containing Senna alata and Eugenia uniflora leaf preparations

Efficacy of antimicrobial sutures in reducing surgical site infection during hernia surgery: a comparative study

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