The effect of triglycerides in the associations between physical activity, sedentary behavior and depression: An interaction and mediation analysis

Huang, Yanhong; Xu, Peng; Fu, Xiangying; Ren, Zhiqiang; Cheng, Jinqun; Lin, Ziqiang; Tan, Jianyi; Huang, Baoying; Huang, Zhenhui; Xu, Huafu; Zhang, Dongmei; Gao, Yanhui

doi:10.1016/j.jad.2021.09.005

Cited by 29 publications

(18 citation statements)

References 57 publications

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“…Secondly, depression data and LPA assessment in our study were based on self–reported questionnaire. However, PHQ9 and PAQ were regarded as “gold standard” criteria for large population–based studies, which has been applied in several previous publications ( 75 , 76 ). In addition, DII score calculated by 24–h dietary recall may not only cause imprecise estimates due to inability in measuring day–to–day variability in dietary intake, but also characterize population or group intake rather than a measure of individual intake ( 77 ).…”

Section: Discussionmentioning

confidence: 99%

Relationship between leisure-time physical activity and depressive symptoms under different levels of dietary inflammatory index

et al. 2022

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Depressive symptoms are major public health problems. Leisure-time Physical activity (LPA) and dietary inflammatory preference are emerging factors that tends to affect the mental health status. There is limited evidence regarding the joint influence of LPA and dietary status on the prevalence of depression. This study was a cross-sectional study, which used a nationwide represented sample from the National Health and Nutrition Examination Survey (NHANES) to assess the relationship among LPA, diet status and depression. Depression and LPA status was reported by the 9-item Patient Health Questionnaire (PHQ-9) and Physical Activity Questionnaire (PAQ), respectively. To assess dietary inflammatory preferences, dietary inflammatory index (DII) was applied based on a 24-h dietary recall interview. A total of 11,078 subjects was included in this study and weighted participants were 89,682,020. Weighted multivariable linear regression showed that DII was negatively associated with LPA after full adjustment, with β (95% CI): −0.487 (−0.647, −0.327). Weighted multivariable logistic regression showed that LPA was significantly associated with depressive symptoms after full adjustment, with odds ratios OR (95% CIs): 0.986 (0.977, 0.995). By DII stratification analysis, this phenomenon was also existed in groups with anti-inflammatory diet. Mediation effect analysis was further performed, which showed that DII significantly mediating the association between LPA and depression with proportion mediated as 3.94%. Our findings indicated the mediating role of DII in the association between LPA condition and incident depression. More well-designed studies are still needed to validate the causal relationship.

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Section: Discussionmentioning

confidence: 99%

Relationship between leisure-time physical activity and depressive symptoms under different levels of dietary inflammatory index

et al. 2022

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“…A two‐sample Mendelian randomization (MR) analysis suggested that high TG levels might be a causal risk factor for depression and its associated characteristics 30 . In the NHANES study, the reference interaction effect of greater TG levels played an important role in the association between sedentary behavior and depression 31 . A meta‐analysis of case‐control studies showed that first‐episode MDD was significantly associated with increased triglyceride levels 13,32 .…”

Section: Discussionmentioning

confidence: 99%

“…30 In the NHANES study, the reference interaction effect of greater TG levels played an important role in the association between sedentary behavior and depression. 31 A metaanalysis of case-control studies showed that first-episode MDD was significantly associated with increased triglyceride levels. 13,32 A smallscale clinical trial reported that treating severe hypertriglyceridemia improved depression.…”

Section: Discussionmentioning

confidence: 99%

Association between triglyceride glucose index and depression in hypertensive population

Zhang,

Zhao,

Guo

et al. 2024

J of Clinical Hypertension

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Growing evidence suggests that hypertensive individuals have a greater risk of developing depression, and depression can also increase the incidence of hypertension. In the hypertensive population, the association between triglyceride glucose (TyG) index and depression remains unclear. This study aimed to assess the association between TyG index and depression in hypertensive people through the cross‐sectional study of the National Health and Nutrition Examination Survey (2007–2018). To assess the relationship between TyG index and depression in hypertensive population, we conducted weighted multiple logistic regression models and used a generalized additive model to probe for nonlinear correlations. In addition, we employed a recursive algorithm to determine the inflection point and established a two‐piece linear regression model. This study enrolled 5897 individuals. In the model adjusted for all covariates, the ORs (95% CI) for the relationship between TyG index and depression in hypertensive population were 1.32 (1.12–1.54). A nonlinear association was found between TyG index and depression, with an inflection point at 8.7. After the inflection point, the ORs (95% CI) were 1.44 (1.15–1.79). Only the interaction with the obese population was statistically significant. Our study highlighted a nonlinear association between TyG index and depression in American hypertensive adults.

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“…Numerous epidemiological studies have established that lifestyle factors are the main risk factors associated with dyslipidemia ( 14 , 15 ). Lifestyle factors are generally considered to be the mediators between SES and health ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

Associations of Socioeconomic Status and Healthy Lifestyle With Incidence of Dyslipidemia: A Prospective Chinese Governmental Employee Cohort Study

Ouyang

et al. 2022

Front. Public Health

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ObjectiveThe purpose of the study was to test whether primary lifestyles mediate associations of SES with incidence of dyslipidemia and to explore interaction relations of lifestyles and SES with incidence of dyslipidemia.MethodsWe included 9,901 individuals at baseline from January 2018 to November 2019, and incidence data were updated to 31 December 2020. Dyslipidemia was defined as total cholesterol (TC) 6.2 mmol/L TC ≥ or triglycerides (TG) ≥2.3 mmol/L or low-density lipoprotein cholesterol (LDL-C) ≥4.1 mmol/L or high-density lipoprotein cholesterol (HDL-C) <1.0 mmol/L; or physician diagnosed dyslipidemia or lipid-lowering drugs use. Lifestyles, socioeconomic factors, and personal characteristics were collected by a questionnaire. A latent class analysis based on education, family income, and occupational position was used to assess the SES. Lifestyle score was calculated using cigarette smoking, alcohol consumption, physical activity, and diet. Cox proportional hazard models and multivariate analyses were used to explore the associations. The mediation effect was evaluated using bootstrap method.ResultsParticipant mean age was 36.5 years (SD = 0.11). The cumulative incidence of dyslipidemia was 11.0% over a mean follow-up of 13.4 months. Compared with participants of high SES, those with low SES had higher risk of incidence of dyslipidemia [hazard ratio 1.32, 95% confidence interval (CI): 1.01–1.73], after adjusting for lifestyle scores and other covariates. The proportion mediated by lifestyles was 5.41% (95%CI: 4.17–7.11). A significant additive interaction was found between lifestyles and SES, whereas association between lifestyle and incidence of dyslipidemia was stronger among those of high SES. Additionally, individuals with low SES and no or one healthy lifestyle behavior had a higher risk of developing dyslipidemia than those with high SES and 3 or 4 healthy lifestyles.ConclusionUnhealthy lifestyles play a small moderating role in socioeconomic inequity in incidence of dyslipidemia among Chinese governmental employees, suggesting that promoting healthy lifestyles alone may not significantly reduce socioeconomic inequalities in health, and measures to address other social determinants of health should also be considered alongside.

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The effect of triglycerides in the associations between physical activity, sedentary behavior and depression: An interaction and mediation analysis

Cited by 29 publications

References 57 publications

Relationship between leisure-time physical activity and depressive symptoms under different levels of dietary inflammatory index

Relationship between leisure-time physical activity and depressive symptoms under different levels of dietary inflammatory index

Association between triglyceride glucose index and depression in hypertensive population

Associations of Socioeconomic Status and Healthy Lifestyle With Incidence of Dyslipidemia: A Prospective Chinese Governmental Employee Cohort Study

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