The effect of trisomic chromosomes on spatial genome organization and global transcription in embryonic stem cells
Mengfan Li,
Junsheng Yang,
Rong Xiao
et al.
Abstract:Aneuploidy frequently occurs in cancer and developmental diseases such as Down syndrome, with its functional consequences implicated in dosage effects on gene expression and global perturbation of stress response and cell proliferation pathways. However, how aneuploidy affects spatial genome organization remains less understood. In this study, we addressed this question by utilizing the previously established isogenic wild‐type (WT) and trisomic mouse embryonic stem cells (mESCs). We employed a combination of … Show more
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