The effect of Tualang honey in enhancing post tonsillectomy healing process. An open labelled prospective clinical trial

Lazim, Norhafiza Mat; Abdullah, Baharudin; Salim, Rosdan

doi:10.1016/j.ijporl.2012.11.036

Cited by 33 publications

(37 citation statements)

References 9 publications

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“…This honey has been extensively studied and has been found to have therapeutic benefits in treating various medical conditions, including protecting post-menopausal bone structure [18], promoting burn wound contraction with antibacterial effects [19], [20], enhancing post-tonsillectomy healing [21], and inhibiting the growth of various cancer cells [22]–[24]. Generally, honey has been traditionally used to treat eye-related diseases [25], [26].…”

Section: Introductionmentioning

confidence: 99%

Tualang Honey Improves Human Corneal Epithelial Progenitor Cell Migration and Cellular Resistance to Oxidative Stress In Vitro

et al. 2014

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Stem cells with enhanced resistance to oxidative stress after in vitro expansion have been shown to have improved engraftment and regenerative capacities. Such cells can be generated by preconditioning them with exposure to an antioxidant. In this study we evaluated the effects of Tualang honey (TH), an antioxidant-containing honey, on human corneal epithelial progenitor (HCEP) cells in culture. Cytotoxicity, gene expression, migration, and cellular resistance to oxidative stress were evaluated. Immunofluorescence staining revealed that HCEP cells were holoclonal and expressed epithelial stem cell marker p63 without corneal cytokeratin 3. Cell viability remained unchanged after cells were cultured with 0.004, 0.04, and 0.4% TH in the medium, but it was significantly reduced when the concentration was increased to 3.33%. Cell migration, tested using scratch migration assay, was significantly enhanced when cells were cultured with TH at 0.04% and 0.4%. We also found that TH has hydrogen peroxide (H2O2) scavenging ability, although a trace level of H2O2 was detected in the honey in its native form. Preconditioning HCEP cells with 0.4% TH for 48 h showed better survival following H2O2-induced oxidative stress at 50 µM than untreated group, with a significantly lower number of dead cells (15.3±0.4%) were observed compared to the untreated population (20.5±0.9%, p<0.01). Both TH and ascorbic acid improved HCEP viability following induction of 100 µM H2O2, but the benefit was greater with TH treatment than with ascorbic acid. However, no significant advantage was demonstrated using 5-hydroxymethyl-2-furancarboxaldehyde, a compound that was found abundant in TH using GC/MS analysis. This suggests that the cellular anti-oxidative capacity in HCEP cells was augmented by native TH and was attributed to its antioxidant properties. In conclusion, TH possesses antioxidant properties and can improve cell migration and cellular resistance to oxidative stress in HCEP cells in vitro.

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Section: Introductionmentioning

confidence: 99%

Tualang Honey Improves Human Corneal Epithelial Progenitor Cell Migration and Cellular Resistance to Oxidative Stress In Vitro

et al. 2014

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“…Intra‐operative administration and postoperative consumption of honey after adeno‐tonsillectomy or tonsillectomy in children led to VAS improvement, less use of painkillers and faster tonsillary fossa healing . In patients who required micro‐vascular‐free tissue reconstruction after the operation of head and neck cancer, honey dressing did not lead to less wound site infection.…”

Section: Resultsmentioning

confidence: 97%

Honey and beehive products in otorhinolaryngology: a narrative review

Henatsch

Wesseling

Kross

et al. 2016

Clinical Otolaryngology

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A total of 36 studies were identified and evaluated. Eighteen studies investigated their effect in oral infections, seven in infection of the respiratory tract, six in rhino-sinusal diseases, four investigated the use in tonsillectomy and head and neck surgery and one study explored the preventive effect in otitis media. Honey can be considered as effective (additional) treatment in mucositis, childhood cough, persistent post-infectious cough and after tonsillectomy. Propolis may have a role in the treatment of (aphthous) stomatitis, mouth ulcer and prevention of acute otitis media. Royal jelly showed to reduce mucositis. In the presented studies, beehive products proved to be safe, with only minor adverse reactions. Studies showed to be diverse and had some methodological limitations.

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“…4 The assessment of tonsillar fossae healing has been described at macroscopic (direct examination) 5 or microscopic levels (punch biopsies). 5,6 Experimental models in humans have primarily evaluated healing through either subjective direct clinical examination of the tonsillar fossae, 7-32 serial photography of the area, 33,34 or the use of magnetic resonance imaging (MRI). 35…”

Section: Results and Analysismentioning

confidence: 99%

Wound healing after tonsillectomy – a review of the literature

et al. 2018

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ObjectiveTo summarise the available literature related to wound healing post tonsillectomy, including the stages of healing, experimental models for assessing healing (in animals and humans) and the various factors that affect wound healing.MethodsA search of the English literature was conducted using the Ovid Medline database, with the search terms ‘tonsillectomy’ or ‘tonsil’ and ‘wound healing’. Thirty-one articles that objectively assessed tonsillectomy wound healing were included for analysis.ResultsThe majority of assessments in humans investigating tonsillectomy wound healing involve serial direct clinical examinations of the oral cavity. Many patient and surgical factors have been shown to affect wound healing after tonsillectomy. There is some research to suggest that the administration of adjunctive treatment in the post-operative period may be beneficial to tonsillectomy wound healing.ConclusionWound healing post tonsillectomy has been poorly researched. Having a better understanding of the process of wound healing would allow surgeons to potentially prevent, anticipate and manage complications from the surgery that arise as part of the healing process.

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The effect of Tualang honey in enhancing post tonsillectomy healing process. An open labelled prospective clinical trial

Cited by 33 publications

References 9 publications

Tualang Honey Improves Human Corneal Epithelial Progenitor Cell Migration and Cellular Resistance to Oxidative Stress In Vitro

Tualang Honey Improves Human Corneal Epithelial Progenitor Cell Migration and Cellular Resistance to Oxidative Stress In Vitro

Honey and beehive products in otorhinolaryngology: a narrative review

Wound healing after tonsillectomy – a review of the literature

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