Background: CAD/CAM Composite is one of the esthetic milled restorations. It has high esthetic properties and modulus of elasticity close to that of dentin. The color stability of composite CAD/CAM restorations is still under investigation. Aim: To evaluate the color stability of milled nano-hybrid composite and hybrid ceramic compared to lithium disilicate after Artificial Accelerated Aging. Materials and Methods: Twenty seven disc-shaped samples (10mm X 2mm) were fabricated in standardized manner. Samples were divided into three equal groups (n=9) according to the material type: Lithium disilicate ceramic (IPS e.max CAD), Hybrid Ceramic (Vita Enamic) and Nano-hybrid CAD/CAM composite (Tetric CAD). Color measurements of the three milled materials were assessed before and after Artificial Accelerated Aging (AAA) in weathering machine for 300 hours using a spectrophotometer based on CIE L*a*b* relative to the standard illumination D65. Color difference was obtained by calculating the difference in color measurements of the specimens before and after accelerated aging using the formula ∆E=[(∆L*) 2 +(∆a*) 2 +(∆b*) 2 ] ½ . Results: There was a statistically significant difference between ΔE of different ceramic types. Tetric CAD showed the highest mean DE (4.29) while there was no statistical significance difference between Vita Enamic and IPS e.max CAD (3.02 and 2.94 respectively). Conclusion: Artificial accelerated aging caused clinically unacceptable color changes in Tetric CAD, while it caused perceptible but clinically acceptable color changes in Vita Enamic and IPS e.max CAD. Color changes after artificial aging is related to the chemical composition of the material.