Ganglion cysts of the wrist are highly prevalent, but a single treatment option is associated with high time and financial costs for the patient. We report a case of a novel treatment option that is simple and efficacious, with a low recurrence rate. Case presentation: A middle-aged woman complained of a cyst on the back of her right wrist, with occasional pain, soreness and swelling on pressure, and limited wrist movement. The patient was clinically diagnosed as "ganglion cyst", and we gave her a acupotomy treatment. After the treatment, the cyst on the back of the wrist disappeared, with no limitation of movement, and there was no recurrence of the cyst 3 months after the treatment. Thus, as a new therapeutic option, acupotomy shows outstanding advantages in the treatment of ganglion cysts. Compared with the traditional surgical options, it is convenient, fast, simple, no scar after surgery, saves the patient's time and economic costs, and avoids the patient's fear of surgery. However, this is only an isolated case, and there is a lack of large sample data to explore its potential mechanism of action.