The effect of underlying diabetes disease on clinical outcome and survival in patients with Covid-19: a propensity score matching study

Ghadamgahi, Fatemeh; Tapak, Leili; Bashirian, Saeed; Amiri, Rahimpour; Roshanaei, Ghodratollah

doi:10.1007/s40200-021-00922-z

Cited by 3 publications

(1 citation statement)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After deleting duplicates, we identified 2463 studies from four databases and then screened articles by title and full text according to the study's objectives. Finally, 69 studies were included in the meta-analysis (Figure 1), of which 62 studies had assessed risk factors for death from COVID 28–89 ); 13 studies determined risk factors for severity (( 41,50,53–55,65,…”

Section: Resultsmentioning

confidence: 99%

Risk Factors Associated with Severity and Death from COVID-19 in Iran: A Systematic Review and Meta-Analysis Study

Mehri

Ghorbani

Farhadi-Babadi

et al. 2023

J Intensive Care Med

View full text Add to dashboard Cite

Objectives: This study aims to investigate the risk factors associated with severity and death from COVID-19 through a systematic review and meta-analysis of the published documents in Iran. Methods: A systematic search was performed based on all articles indexed in Scopus, Embase, Web of Science (WOS), PubMed, and Google Scholar in English and Scientific Information Database (SID) and Iranian Research Institute for Information Science and Technology (IRA)NDOC indexes in Persian. To assess quality, we used the Newcastle Ottawa Scale. Publication bias was assessed using Egger's tests. Forest plots were used for a graphical description of the results. We used HRs, and ORs reported for the association between risk factors and COVID-19 severity and death. Results: Sixty-nine studies were included in the meta-analysis, of which 62 and 13 had assessed risk factors for death and severity, respectively. The results showed a significant association between death from COVID-19 and age, male gender, diabetes, hypertension, cardiovascular disease (CVD), cerebrovascular disease, chronic kidney disease (CKD), Headache, and Dyspnea. We observed a significant association between increased white blood cell (WBC), decreased Lymphocyte, increased blood urea nitrogen (BUN), increased creatinine, vitamin D deficiency, and death from COVID-19. There was only a significant relationship between CVD and disease severity. Conclusion: It is recommended that the predictive risk factors of COVID-19 severity and death mentioned in this study to be used for therapeutic and health interventions, to update clinical guidelines and determine patients’ prognoses.

show abstract

Section: Resultsmentioning

confidence: 99%

Risk Factors Associated with Severity and Death from COVID-19 in Iran: A Systematic Review and Meta-Analysis Study

Mehri

Ghorbani

Farhadi-Babadi

et al. 2023

J Intensive Care Med

View full text Add to dashboard Cite

show abstract

The Role of Diabetes on the mortality rate of Patients with COVID-19: A systematic review

Saki,

Nemati,

Ebrahimi

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Type 2 Diabetes Mellitus (T2DM) as a burgeoning health concern in the context of COVID-19 emphasizes the need for solicitous attention and tailored preventive strategies to reduce morbidity and mortality risk. Consistent with this attitude, this systematic review aimed to highlight a wide range of predictive factors that could be related to worse outcomes in COVID-19_DM patients. Methods: The search was done in Pub Med, Web of Sciences, and Science Direct databases using keywords Diabetes, COVID-19, and mortality rates from September 2020 until April 2022 to identify and evaluate the numerous possible prognostic factors that are associated with significant mortality rates in COVID-19_DM patients. Results: Among more than 1200 Studies, 10 articles were considered eligible for more evaluation and were taken forward to the full-text review. Additionally, among more than 25000 COVID-19 patients and more than 6000 COVID-19_DM patients, older age and male gender were the most important mortality-related predictors in COVID-19_DM patients which were pointed out in 5 and 4 studies respectively. It should be noted, that high D-dimer and blood glucose levels could potentiate the risk of death in COVID-19_DM patients. Conclusion: In conclusion and in addition to older age, male gender, high D-dimer, and blood glucose levels, there were several determinant factors like high ferritin, Procalcitonin, A1C (HBA1C), White Blood Cell (WBC), C-Reactive Protein (CRP) level, and also lower Oxygen (O2) saturation and lymphocyte count that are related with the mortality risk in patients. Likewise, pulmonary involvement and some medications like exogenous insulin could result in a debilitating condition in COVID-19_DM patients.

show abstract

Evaluating the Effect of Underlying Pulmonary Disease on the Clinical Outcome and survival among Patients with COVID-19: Using Propensity Score Matching

Safari,

Ghadamgahi,

Faradmal

et al. 2024

TOPHJ

Self Cite

View full text Add to dashboard Cite

Background: Coronavirus (Covid-19) is a life-threatening factor throughout the world. Having an underlying disease among the patients with this disease diminishes the clinical effectiveness and increases their mortality rate. Hence, the study was carried out to compare the clinical outcomes in patients with COVID-19 with and without pulmonary disease using propensity score matching. Methods: This case-control study was conducted on 299 COVID-19 patients with pulmonary disease (case group) and 299 COVID-19 patients without pulmonary diseases (control group). Matching the patients in the case and control groups was done using propensity score matching. Logistic regression was used to assess the effect of factors on the patient's clinical outcome (recovery-death), and the Cox model was used to determine the factors affecting patient survival. Data were analyzed in R software. Results: The mean (SD) of the patients' age in the case and control groups was 65.49 (15.55) and 65.67 (15.55), respectively. The results of the logistic regression model showed that age, pulmonary disease, nausea, and blood oxygen affect patient death. The results of the Cox proportional-hazards model indicated that the variables of age, blood oxygen, and pulmonary had a significant effect on patient survival. Conclusion: Given the high mortality rate among patients with COVID-19 and chronic pulmonary disease, these patients are considered a high-risk group and need special care.

show abstract

The effect of underlying diabetes disease on clinical outcome and survival in patients with Covid-19: a propensity score matching study

Cited by 3 publications

References 50 publications

Risk Factors Associated with Severity and Death from COVID-19 in Iran: A Systematic Review and Meta-Analysis Study

Risk Factors Associated with Severity and Death from COVID-19 in Iran: A Systematic Review and Meta-Analysis Study

The Role of Diabetes on the mortality rate of Patients with COVID-19: A systematic review

Evaluating the Effect of Underlying Pulmonary Disease on the Clinical Outcome and survival among Patients with COVID-19: Using Propensity Score Matching

Contact Info

Product

Resources

About