“…The observations on patients with chronic congestive heart failure re ported here are in agreement with more fragmentary earlier studies by Howard and Leathart [7], who in 1951 first reported patients with left ventri cular failure who increased their pulse pressure upon upright tilt, without changing their heart rate, as well as with several more recent studies of the hemodynamic effects of orthostatic stress upon patients in heart failure [3,4,11,13]. Together with these earlier studies, the present investigations establish that tolerance of orthostatic stress is increased in chronic con gestive heart failure, resulting in excellent tolerance of acute depletion of plasma volume as well as chronic immobilization, and suggest that increased circulatory blood volume, increased sympathetic tone and possibly chronic hypoxia [9] play a role in this tolerance.…”