The Effect of Uranium Poisoning on Plasma Diodrast Clearance and Renal Plasma Flow in the Dog

Bobey, Milton E.; Longley, Lesa; Dickes, Robert; Price, J. Waide; Hayman, J. M.

doi:10.1152/ajplegacy.1943.139.1.155

Cited by 40 publications

(6 citation statements)

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“…He noted the absence of urine formation in spite of normal or augmented glomerular filtration. Additional evidence cited for the occurrence of abnormal tubular permeability is the finding of negative TmD's 3 by Bobey et al (7) and of decreased creatinine/inulin clearance ratios by Richards, Westfall, and Bott (8) in experimental uranium poisoning in dogs; the demonstration of negative TmPAH values by Redish, West, White-1 Indebtedness is gratefully acknowledged to the U. S. Standard Products Co., of Woodworth, Wisconsin, for furnishing inulin in generous amounts for parenteral use in this work. 2 Sarah Welt Fellow, permanent address: Department of Medicine, The Mount Sinai Hospital, New York City.…”

mentioning

confidence: 97%

Carbon Tetrachloride Poisoning in Man. I. The Mechanisms of Renal Failure and Recovery 1

Sirota¹,

Warmbrand²

1949

J. Clin. Invest.

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mentioning

confidence: 97%

Carbon Tetrachloride Poisoning in Man. I. The Mechanisms of Renal Failure and Recovery 1

Sirota¹,

Warmbrand²

1949

J. Clin. Invest.

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“…Inulin and diodone were injected subcutaneously as one injection. This mode of administration has recently been used with satisfactory results by several investigators (Findley & White, 1940; Heinbecker, Rolf & White, 1943;Bobey, Longley, Dickes, Price & Hayman, 1943). The doses per animal ranged from 2-0 to 4-0 ml.…”

mentioning

confidence: 98%

The mechanism of water diuresis in normal rats and rabbits as analysed by inulin and diodone clearances

Dicker¹,

Heller²

1945

The Journal of Physiology

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Renal clearances of inulin and diodone, and hence certain important aspects of renal function, have hitherto only been incompletely studied in small laboratory animals. Kaplan & Smith (1935) estimated inulin clearances in rabbits and found that, in contrast to certain other mammalian species like the dog and human adults, inulin clearances increased with increasing urine flow. Diodone clearances in rabbits do not seem to have been recorded. Determination of inulin and diodone clearances in rats have recently been reported (Friedman & Livingstone, 1942). However, there are several features of the experimental technique used by these investigators which would seem to limit the usefulness of their results. (1) The urine samples were obtained from anaesthetized animals (type of anaesthetic not stated). (2) Owing probably to the use of an anaesthetic, the urine flow of their animals was uniformly very low (M. = 0-0033 ml./100 g./min., S.D. = + 0.00157) and this in spite of the fact that a saline diuretic (2 % sodium sulphate) had been administered some time before the experiment started. (3) Friedman & Livingstone's results, based on experiments on animals with a very limited range of urine flow, do not make it clear whether inulin clearances, and thus glomerular filtration rates, of rats change with alterations in urine flow. That is to say, it is not possible to see from their experiments whether, with reference to this important feature, renal function in the rat conforms to the 'rabbit type' or to the 'human type' of kidney.It is clear that the interrelation between inulin and diodone clearances and rate of urine flow had to be ascertained if, as in the present case, clearance determinations on normal rats and rabbits were meant to precede work which would involve experimental changes of renal function. A study of the renal mechanism of water diuresis was implicit in such an investigation.

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“…The interpretation of both endogenous "creatinine" and inulin clearance data as indicators of glomerular activity during severe renal insufficiency is open to question. There is evidence to suggest that tubular back-diffusion of the glomerular filtrate or some of the filtrate solutes may occur following severe renal injuries (14)(15)(16)(17). Under such circumstances the renal clearances of endogenous "creatinine" and inulin may be considerably lower than the true glomerular filtration rate, and hence the filtered potassium load calculated from these data may be significantly lower than the true values.…”

Section: Discussionmentioning

confidence: 99%

Evidence Suggesting Renal Tubular Excretion of Potassium in Man During Recovery From Acute Renal Insufficiency 1

Sirota¹,

Kroop²,

Warmbrand³

1951

J. Clin. Invest.

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The Effect of Uranium Poisoning on Plasma Diodrast Clearance and Renal Plasma Flow in the Dog

Cited by 40 publications

References 0 publications

Carbon Tetrachloride Poisoning in Man. I. The Mechanisms of Renal Failure and Recovery 1

Carbon Tetrachloride Poisoning in Man. I. The Mechanisms of Renal Failure and Recovery 1

The mechanism of water diuresis in normal rats and rabbits as analysed by inulin and diodone clearances

Evidence Suggesting Renal Tubular Excretion of Potassium in Man During Recovery From Acute Renal Insufficiency 1

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