The Effect of Uremic Blood on Mixed Leukocyte Reactions and on Cultures of Leukocytes With Phytohemagglutinin

Kasakura, S; Lowknstein, Louis

doi:10.1097/00007890-196703000-00017

Cited by 87 publications

(40 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Variable results of in vitro lympho cyte blastogenesis in uremic patients have been found. Several investigators found that lymphocytes suspended in normal human or fetal calf serum had decreased proliferative response to phytohemagglutinin, concanavalin A, or tuberculin purified protein [18,22,53,54] while others have reported a normal or increased lymphocyte response [11,20,37], One consistent finding is that uremic serum or plasma is inhibitory for normal or uremic lymphocyte responses to mitogens [18, 20, 38. 54, 55], When lymphocytes from uremic patients are washed and resuspended in normal se rum, the suppression is reversed [55,56].…”

Section: Altered In Vitro Lymphocyte Functionmentioning

confidence: 99%

Immune Abnormalities in Renal Failure and Hemodialysis

Kay¹,

Raij²

1986

Blood Purif

View full text Add to dashboard Cite

Considerable work needs to be done in order to understand the immunosupressive effect of ‘uremia’ and the lymphocyte changes induced by hemodialysis. For example, the lymphocyte population dynamics can be further defined using monoclonal antibodies specific for lymphocyte subgroups. In vitro assays are available for lymphokine detection (i.e. IL-1, IL-2 which are important for T cell function) and may be correlated with both the clinical state and overall immunobiological status of hemodialyzed patients. The possibility of specifically delineating the extent of the immune system dysfunction in renal failure patients (on or off dialysis) is at hand. With this knowledge it will be possible to manipulate their management so as to minimize function alterations.

show abstract

Section: Altered In Vitro Lymphocyte Functionmentioning

confidence: 99%

Immune Abnormalities in Renal Failure and Hemodialysis

Kay¹,

Raij²

1986

Blood Purif

View full text Add to dashboard Cite

show abstract

“…One reasonable explanation could be that at least some of these tumors or even some of those with a later appearance were already present at the time of transplantation, but were small and undetected, and grew rapidly under the influence of the immunosuppressive therapy. This raises the question whether chronic renal failure per se may predispose the patient to malignant disease (15) by virtue of the well known depression in uremia of immune responses (6,10,13,32).…”

Section: Borderline Lesionsmentioning

confidence: 99%

Malignant Tumors Arising De Novo in Immunosuppressed Organ Transplant Recipients

Penn¹,

Starzl²

1972

Transplantation

290

View full text Add to dashboard Cite

SummaryDe novo malignant tumors have been observed throughout the world in 75 chronic survivors of organ transplantation, including 16 of our own patients. The incidence of tumors was approximately 80 times greater than in the average population in a comparable age range. Chronic uremia may have predisposed to the development of some of the tumors, but this has not yet been proved. It seems clear that the predominant etiology was chronic immunosuppression posttransplantation. Forty-four of the patients had epithelial tumors and in 31 the lesions were of mesenchymal origin. On the average the malignancies appeared 29 months after transplantation. Lymphomas showed an unusual predilection for involvement of the central nervous system.

show abstract

“…'apidly under the intiuence of the immunosuppressh-e therapy. This rnises the question whether chronic renal failure per se may predispose the patient to malignant disease (15) by virtue of the well known depression in uremia of immune responses (6,10,13,32).…”

Section: Borderline Lesionsmentioning

confidence: 99%

Malignant tumors arising de novo in immuno-suppressed organ transplant recipients

Penn¹,

Starzl²

1973

Plastic and Reconstructive Surgery

View full text Add to dashboard Cite

SUMMARYDe novo malignant tumors have been observed throughout the world in 75 chronic survivors of organ transplantation, including 16 of our own patients. The incidence of tumors was approximately 80 times greater than in the average population in a comparable age range. Chronic uremia may have predisposed to the development of some of the tumors, but this has not yet been proved. It seems clear that the predominant etiology was chronic immunosuppression post-transplantation. Forty-four of the patients had epithelial tumors and in 31 the lesions were of mesenchymal origin. On the average the malignancies appeared 29 months after transplantation. Lymphomas showed an unusual predilection for involvement of the central nervous system. Carcinomas of the skin, lip, and uterine cervix were successfully treated by conventional techniques. On the other hand, carcinomas of the thoracic or abdominal organs and mesenchymal tumors led or contributed to early death in most cases. For this reason drastic reduction or even discontinuance of immunosuppression should be considered in the management of these , latter tumors.

show abstract

The Effect of Uremic Blood on Mixed Leukocyte Reactions and on Cultures of Leukocytes With Phytohemagglutinin

Cited by 87 publications

References 0 publications

Immune Abnormalities in Renal Failure and Hemodialysis

Immune Abnormalities in Renal Failure and Hemodialysis

Malignant Tumors Arising De Novo in Immunosuppressed Organ Transplant Recipients

Malignant tumors arising de novo in immuno-suppressed organ transplant recipients

Contact Info

Product

Resources

About