The effect of ursodeoxycholic acid in liver functional restoration of patients with obstructive jaundice after endoscopic treatment: a prospective, randomized, and controlled study

Fekaj, Enver; Gjata, Arben; Maxhuni, Mehmet

doi:10.1186/1471-2482-13-38

Cited by 6 publications

(5 citation statements)

References 19 publications

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“…In primary rat hepatocytes, UDCA was shown to downregulate p53 expression and prevent apoptosis signaling through reduction of Bcl- 2(B-cell lymphoma 2) associated X protein (Bax) expression, mitochondrial translocation, and cytochrome c release [14]. Clinical studies showed that UDCA intervention was able to restore the liver function of obstructive jaundice patients after endoscopic treatment [75]. Intrahepatic cholestasis (ICP) is a pregnancy liver disorder that is reported to affect pregnancy during the third trimester and is mostly treated with UDCA.…”

Section: The Most Hydrophilic Bile Acids—ursodeoxycholic Acidmentioning

confidence: 99%

Overview of Bile Acids Signaling and Perspective on the Signal of Ursodeoxycholic Acid, the Most Hydrophilic Bile Acid, in the Heart

Hanafi

Kadir

et al. 2018

Biomolecules

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Bile acids (BA) are classically known as an important agent in lipid absorption and cholesterol metabolism. Nowadays, their role in glucose regulation and energy homeostasis are widely reported. BAs are involved in various cellular signaling pathways, such as protein kinase cascades, cyclic AMP (cAMP) synthesis, and calcium mobilization. They are ligands for several nuclear hormone receptors, including farnesoid X-receptor (FXR). Recently, BAs have been shown to bind to muscarinic receptor and Takeda G-protein-coupled receptor 5 (TGR5), both G-protein-coupled receptor (GPCR), independent of the nuclear hormone receptors. Moreover, BA signals have also been elucidated in other nonclassical BA pathways, such as sphingosine-1-posphate and BK (large conductance calcium- and voltage activated potassium) channels. Hydrophobic BAs have been proven to affect heart rate and its contraction. Elevated BAs are associated with arrhythmias in adults and fetal heart, and altered ratios of primary and secondary bile acid are reported in chronic heart failure patients. Meanwhile, in patients with liver cirrhosis, cardiac dysfunction has been strongly linked to the increase in serum bile acid concentrations. In contrast, the most hydrophilic BA, known as ursodeoxycholic acid (UDCA), has been found to be beneficial in improving peripheral blood flow in chronic heart failure patients and in protecting the heart against reperfusion injury. This review provides an overview of BA signaling, with the main emphasis on past and present perspectives on UDCA signals in the heart.

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Section: The Most Hydrophilic Bile Acids—ursodeoxycholic Acidmentioning

confidence: 99%

Overview of Bile Acids Signaling and Perspective on the Signal of Ursodeoxycholic Acid, the Most Hydrophilic Bile Acid, in the Heart

Hanafi

Kadir

et al. 2018

Biomolecules

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“…Непрерывная заместительная почечная терапия и прерывистый гемодиализ эффективны у пациентов с тяжелым сепсисом и острой почечной недостаточностью. Плазмосорбция и плазмофильтрация снижают уровень билирубина и других токсических метаболитов, образующихся на фоне МЖ и холестаза, но пролонгированный эффект отмечается только при адекватной билиарной декомпрессии [44][45][46].…”

Section: раздел 2 консервативные методы лечения больных с мжunclassified

Diagnostic and conservative treatment nuances in patients with obstructive jaundice: in the wake of Russian consensus

Khatkov¹,

Евгеньевич²,

Avanesyan³

et al. 2021

Terapevticheskii arkhiv

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The research was performed at the Loginov Moscow Clinical Scientific Center. It is based on Russian obstructive jaundice (OJ) consensus results, considered at the 45th annual Central Research Institute of Gastroenterology Scientific session Oncological issues in the gastroenterologist practice (1 March 2019). The article objective is to note the diagnostic and conservative treatment current issues in patients with OJ. The increase in the number of patients with OJ of different etiology provides problem actuality. In a large number of cases, medical treatment is delayed due to inadequate diagnostic and management, while correct patients routing today can be provided regardless of medical institution level. In this article the examination steps and conservative treatment role in patients with biliary obstruction management are presented.

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“…Clinical studies show that UDCA intervention able to restore the liver function of obstructive jaundice patients after the endoscopic treatment [86]. Intrahepatic cholestasis (ICP) is a pregnancy liver disorder reported to affect pregnancy during the third trimester and mostly treated with UDCA.…”

Section: Udca As a Therapeutic Agentmentioning

confidence: 99%

Bile Acid Signaling and Cardioprotection

Hanafi¹,

As²,

Sh³

2018

Preprint

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Bile acids (BA) are classically known as an agent important in lipid absorption and cholesterol metabolism. Nowadays, BAs have been found to be involved in various cellular signaling pathways such as protein kinase cascades, cyclic AMP (cAMP) synthesis and calcium mobilization. In addition, they have also been shown to regulate glucose and energy homeostasis. Bile acids are ligands for several nuclear hormone receptors, including FXR. Recently, muscarinic receptor and TGR5, G-protein-coupled receptor (GPCR), have been suggested to play a role in bile acid activity which is independent of nuclear hormone receptors. Moreover, BAs have also been studied in other GPCR associated pathways, namely sphingosine-1-posphate and glucagon receptor. Hydrophobic bile acids have been proven to affect heart rate and its contraction. Elevated bile acids are associated with arrhythmias in adults and fetal heart. Altered ratios of primary and secondary bile acid are reported in chronic heart failure patients. Meanwhile in patients with liver cirrhosis, cardiac dysfunction has been strongly linked to the increase of serum bile acid concentrations. In contrast, the most hydrophilic BA known as ursodeoxycholic acid has been found beneficial in improving peripheral blood flow in chronic heart failure patients and protecting heart against reperfusion injury.

show abstract

The effect of ursodeoxycholic acid in liver functional restoration of patients with obstructive jaundice after endoscopic treatment: a prospective, randomized, and controlled study

Cited by 6 publications

References 19 publications

Overview of Bile Acids Signaling and Perspective on the Signal of Ursodeoxycholic Acid, the Most Hydrophilic Bile Acid, in the Heart

Overview of Bile Acids Signaling and Perspective on the Signal of Ursodeoxycholic Acid, the Most Hydrophilic Bile Acid, in the Heart

Diagnostic and conservative treatment nuances in patients with obstructive jaundice: in the wake of Russian consensus

Bile Acid Signaling and Cardioprotection

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