The effect of using tadalafil 5 mg/day on neutrophil–lymphocyte and platelet–lymphocyte ratios in mild‐medium and severe erectile dysfunction patients; and comparison of clinical response

Abstract

To examine the relation between NLR (neutrophil–lymphocyte ratio) and PLR (platelet–lymphocyte ratio) rates and the severity of ED (erectile dysfunction) and the effect of tadalafil 5 mg/day on these, a total of 143 patients were retrospectively evaluated. Sixty‐three patients with ED who came for follow‐up examinations in the 1st month of the treatment were included as the study group, and 80 men who were not diagnosed with ED were as the control group. The age and Charlson Comorbidity Indexes (CCI) of the study and control groups were compared with the IIEF 5, NLR and PLR values before and after the treatment. The mean age and median CCI were higher in the severe ED group (p < 0.05). The mean NLR and PLR values were lower in the control group (p < 0.001). In the study group, the NLR and PLR values decreased with the increase in the IIEF 5 scores (p < 0.001). The ROC curve was significant for the NLR and PLR scores (AUC = 0.779, [95% CI: 0.698–0.860]; AUC = 0.754, [95% CI: 0.670–0.838] p < 0.001). Although more prospective and randomized studies are needed, the systemic inflammation decreases and the clinical symptoms improve in patients who use tadalafil 5 mg/day.

The effect of cardiovascular morbidity on clinical response provided by tadalafil in patients with erectile dysfunction

“…Findings associated with this result are also different in other studies. Porst et al (2014) observed higher improvement following daily tadalafil administration in patients with mild ED, whereas Demirci & Ozgur (2019) observed higher recovery rates in severe ED patients. On the other hand, Suetomi et al (2008) observed that both baseline and post-treatment IIEF scores were inversely correlated with an increase in the number of MetS components.…”

The interaction between inflammation, urinary symptoms and erectile dysfunction in early‐stage prostate cancer treated with brachytherapy

“…In the study by Demirci & Ozgur (2019), the NLR increased with ED severity: in patients with mild‐moderate ED ( n = 30), the mean value was 1.83 compared to patients with severe ED ( n = 33) who had a mean NLR of 1.93.…”

“…We chose this cut‐off of NLR ≥ 3 versus <3 because it is very close to the mean value and has been used in previous studies analysing the influence of NLR on ED. Demirci and Ozgur (2019) showed a significant inverse correlation between the NLR and the IIEF‐5 score. Ventimiglia et al.…”

“…Chronic inflammation may be one of the factors contributing to ED, BPH and prostate cancer (Vlachopoulos et al., 2007). Patients with ED seem to generally have low‐grade systemic inflammation, as evidenced by elevated inflammatory markers including the neutrophil‐to‐lymphocyte ratio (NLR; Demirci & Ozgur, 2019; De Marzo et al., 2007; Nguyen et al., 2014; Vlachopoulos et al., 2007). NLR has shown a correlation not only with ED (Demirci & Ozgur, 2019) but also with severe urinary symptoms in patients with BPH (Ozer et al., 2017; Tanik et al., 2014).…”

A systematic review and meta‐analysis of the relationship between erectile dysfunction and the neutrophil‐to‐lymphocyte and platelet‐to‐lymphocyte ratios

“…Then, 11 studies with full text were further reviewed for eligibility of our meta-analysis, excluding 27 records for unrelating to our topic. Eventually, 7 studies were remained for our meta-analysis, meeting the predefined inclusion criteria (Akbas et al, 2016;Aslan et al, 2019;Demirci & Ozgur, 2019;Demirci et al, 2020;Erdogan et al, 2020;Liao et al, 2021;Sambel et al, 2018). Among the 7 eligible studies, a total of 929 ED patients and 737 healthy controls were included in our meta-analysis.…”