The effect of various adjuvants on the humoral immune response of sheep and cattle to soluble and membrane midgut antigens of Boophilus microplus

Jackson, Louise A.; Opdebeeck, J.P.

doi:10.1016/0304-4017(94)00703-f

Cited by 13 publications

(4 citation statements)

References 24 publications

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“…However, its general use has been limited until recently, although it is one of the most efficient adjuvants available. A study on the effect of various adjuvants in a vaccine against cattle tick Boophilus microplus, in both cattle and sheep, has shown that Quil-A was superior to IFA and aluminium hydroxide adjuvant, and it has given greater than 80% protection in both cattle and sheep [34]. It has also been used successfully to induce CD8 þ CTL with synthetic peptides [35].…”

Section: Discussionmentioning

confidence: 99%

Vaccine‐Induced Th1‐Type Responses are Dominant over Th2‐Type Responses in the Short Term whereas Pre‐existing Th2 Responses are Dominant in the Longer Term

et al. 1998

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The effect of adjuvant on induction of human papillomavirus type 16 E7 protein-specific cytotoxic T lymphocytes (CTL) and immunoglobulin G (IgG)2a antibody was studied in C57BL/6 J mice immunized with various adjuvants and E7 protein. Quil-A adjuvant, but not complete Freund's adjuvant (CFA) or Algammulin, induced a T-helper 1 (Th1)-type response to E7, which was characterized by CTL activity against a tumour cell line transfected with E7 protein and by E7-specific IgG2a. All tested adjuvants elicited comparable levels of E7-specific IgG1. The longest duration and greatest magnitude of CTL response was seen following two immunizations with the highest dose of E7 and Quil-A. Simultaneous immunization with a Th1 and a T helper 2 (Th2)-promoting adjuvant gave a Th1-type response. However, E7 and Quil-A were unable to induce a Th1-type response (as measured by the inability to generate anti-E7 IgG2a antibody) in animals with a pre-existing Th2-type response to E7. These results suggest that saponin adjuvants may be suitable for immunotherapy in humans where a Th1-type response is sought, provided that there is no pre-existing Th2-type response to the antigen.

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Section: Discussionmentioning

confidence: 99%

Vaccine‐Induced Th1‐Type Responses are Dominant over Th2‐Type Responses in the Short Term whereas Pre‐existing Th2 Responses are Dominant in the Longer Term

et al. 1998

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“…Finally, the use of crude extracts or purified recombinant antigen, as well as the choice in adjuvant, can also contribute to the efficacy of the final vaccine formulation (Zepp 2010;Leroux-Roels 2010). Examples of the effect of these factors on immunization of cattle with R. microplus antigens have been published (Almazan et al 2011;Jackson and Opdebeeck 1995).…”

Section: Vaccine Antigen Contributing Factorsmentioning

confidence: 99%

A systematic, functional genomics, and reverse vaccinology approach to the identification of vaccine candidates in the cattle tick, Rhipicephalus microplus

Maritz-Olivier

Zyl

Stutzer

2012

Ticks and Tick-borne Diseases

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“…The bovine immune response to DNA, protein, and viral antigens has been studied to assess the relative importance of injection site (Boerhout et al, 2015), adjuvant (Jackson and Opdebeeck, 1995;Rajput et al, 2007;Kateregga et al, 2012), added immunomodulatory proteins (Manoj et al, 2004;Maue et al, 2004), and timing relative to conception (Kramski et al, 2012). However, these studies have typically been quite small, with 1 to 7 animals per group.…”

Section: Introductionmentioning

confidence: 99%

Serum and colostral antibody production in cows immunized with recombinant human tumor necrosis factor

Burton

Kim

Patel

et al. 2016

Journal of Dairy Science

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The use of hyper-immune bovine colostrum as a human therapeutic platform is an emerging technology with potential to deliver the efficacy of antibody therapeutics with the convenience and safety of oral or topical application. It is necessary to understand how the bovine immune system responds to immunization with foreign proteins, both in terms of the serum antibody response and the transfer of antigen-specific antibodies into the colostrum to enable efficient large-scale production of therapeutic antibodies. We have immunized 25 cows with recombinant human tumor necrosis factor (rhTNF) and measured the levels of rhTNF-specific antibodies in the serum and colostrum of these animals. We observed a decline of 84±9% in serum IgG1 concentrations in the final weeks of pregnancy that presumably reflects rapid transport of IgG1 into colostrum. The serum IgG2 levels remained constant, such that the serum IgG1 to IgG2 ratio was 1:20 at parturition. We observed substantial animal-to-animal variability in the levels of anti-rhTNF antibodies in both serum and colostrum samples. In particular, a subset of 4 cows had extraordinarily high colostral anti-rhTNF antibody production. Only a weak correlation was found between the peak serum anti-rhTNF activity and the colostral anti-rhTNF activity in these animals. The 4 cows with high colostral anti-rhTNF activities trended toward higher serum IgG1 loss relative to average colostral anti-rhTNF producers, but this difference was not statistically significant in this small sample. The high-anti-rhTNF-producing cows also exhibited a greater proportion of rhTNF-specific antibodies that bound to bovine IgG1- and IgG2-specific detection antibodies relative to the total anti-rhTNF immunoglobulin population. This finding suggests that the isotype distribution of the anti-rhTNF response is varied between individuals and genetic or environmental factors may increase the yield of antigen-specific colostral antibodies.

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The effect of various adjuvants on the humoral immune response of sheep and cattle to soluble and membrane midgut antigens of Boophilus microplus

Cited by 13 publications

References 24 publications

Vaccine‐Induced Th1‐Type Responses are Dominant over Th2‐Type Responses in the Short Term whereas Pre‐existing Th2 Responses are Dominant in the Longer Term

Vaccine‐Induced Th1‐Type Responses are Dominant over Th2‐Type Responses in the Short Term whereas Pre‐existing Th2 Responses are Dominant in the Longer Term

A systematic, functional genomics, and reverse vaccinology approach to the identification of vaccine candidates in the cattle tick, Rhipicephalus microplus

Serum and colostral antibody production in cows immunized with recombinant human tumor necrosis factor

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