The Effect of Various Types of Fat on the Cholesterol Distribution in the Rat

Abstract

Experiments were conducted with and without addition of 1 per cent cholesterol to diets containing 20 per cent of fats of the following types: 1. corn oil, 2. 19.5 per cent hydrogenated coconut oil and 0.5 per cent corn oil, and 3. 12 per cent hydrogenated coconut oil and 8 per cent olive oil. Following a 3 weeks' pre‐experimental period on a fat free diet adult female rats were given the experimental diets for 6 weeks. In rats given cholesterol corn oil caused the well known transfer of cholesterol from plasma to the liver. In rats given diets containing cholesterol and corn oil the cholesterol content of the liver was considerably higher and serum cholesterol much lower in rats given the diet containing olive oil. The result indicate that linoleic acid probably enhances cholesterol absorption over and above the effect of oleic acid. The carcass cholesterol of rats given corn oil was slightly lower than in rats given type 2 of fat. The difference was statistically significant on cholesterol free diets. When various tissues were analysed corn oil induced transfer to other tissues than the liver could not be observed.

God Liver Oil Induced Removal of Cholesterol in Hypercholesterolemic Essential Fatty Acid Deficient Rats

“…The experiments presented here were done before the experiments in adult rats. (Gran and Nicolaysen 1966) were started. The erroneously high tissue cholesterol values obtained with the Tschugaeff method have been documented by us.…”

“…The rats were killed at the conclusion of the experiments by a stunning blow over the neck and exsanguinated. The methods for tissue analyses have been described by Gran and Nicolaysen (1966).…”

“…The effects of various types of fats, included in substantial proportions in the diet, on the distribution and metabolism of cholesterol have been discussed elsewhere (Gran and Nicolaysen 1966). When the level of fat in the diets is 10-40 per cent, numerous mechanisms known to be active in cholesterol metabolism can come into play.…”

“…When the level of fat in the diets is 10-40 per cent, numerous mechanisms known to be active in cholesterol metabolism can come into play. We refer to a recent discussion by Avigan and Steinberg (1965) and to Gran and Nicolaysen ( 1966).…”

Effects of Okinawan sugar cane rind on serum and liver cholesterol and triglyceride levels in the rat.

“…However, the results of the present study demonstrated that sugar cane rind has an effect on weight control of rats, showing a significant difference between groups II and IV. Kaunitz and Johnson (17), and Gran and Nicolaysen (18) reported that feeding vegetable oil, which contains a high percentage of polyunsaturated fatty acids decreases serum Chol in rats. In our present experiment, rats fed corn oil (containing over 50% linoleic acid) instead of lard (group III) resulted in showing a significantly lower serum Chol level.…”