The effect of varying albumin concentration of the hydraulic conductivity of the rabbit common carotid artery

Tarbell, John M.; Lever, M. J.; Caro, C.G.

doi:10.1016/0026-2862(88)90063-5

Cited by 65 publications

(66 citation statements)

References 17 publications

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“…The transients observed were similar to those seen in a previous study with this artery preparation (Tarbell et al 1988) and are currently not understood. After flushing fresh solutions through the vessel and on the other occasions when flow was stopped, the transmural flux invariably fell with time before reaching a new steady state (Fig.…”

Section: Discussionsupporting

confidence: 75%

“…The common carotid arteries of rabbits were cannulated and excised in a manner previously described in detail (Tarbell, Lever & Caro, 1988 (Tedgui, Chiron, Curmi & Juan, 1987) and B turned off to the reservoirs, it was also possible to monitor flow into the lumen of the artery by following the movement of an air bubble towards the vessel in the pressurized capillary tube A. Bubble movement was followed continuously with a travelling microscope which was linked to a recorder via a linear transducer.…”

Section: Methodsmentioning

confidence: 99%

“…The plasma constituents most likely to undergo concentration polarization are proteins, which have low diffusivities and high osmotic reflection coefficients. The formation of a concentrated protein layer at the luminal surface of a vessel would produce a local increase in the colloid osmotic pressure relative to that in the bulk of the solution, and as a result cause a reduction of the transmural flux of fluid (Tarbell, Lever & Caro, 1988).…”

Section: Introductionmentioning

confidence: 99%

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The effect of luminal flow in rabbit carotid artery on transmural fluid transport

Lever¹,

Tarbell²,

Caro³

1992

Experimental Physiology

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SUMMARYThe steady-state flow of fluid across the wall of the isolated rabbit common carotid artery has been measured in the presence and absence of flow within the lumen of the vessel. The perfusate solution contained either 10 or 40 mg ml-' albumin and transmural flux was measured by monitoring the rate of movement of fluid into a chamber enclosing the artery. Vasomotion was minimized by the inclusion of the vasodilator sodium nitrite in both the perfusate and the outer bathing solution. A relatively slow luminal flow caused a reversible increase in the transmural flux by 20 30 % relative to the value in the absence of flow. The mechanism responsible for the increasc is not clear, but since it was not affccted by the H1 antagonist, mepyramine, it would not appear to have been mediated by histamine release.

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Section: Discussionsupporting

confidence: 75%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The effect of luminal flow in rabbit carotid artery on transmural fluid transport

Lever¹,

Tarbell²,

Caro³

1992

Experimental Physiology

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“…There is little previous work on the physiological effect of intra-articular protein, although viscosity-related reductions in interstitial flow by albumin have been described in artery walls (Tarbell, Lever & Caro, 1987). Edlund (1949) injected haemoglobin into rabbit knees (55 g 1`, 7 r r = 25 cmH20) and found no change in the characteristic shape of the trans-synovial pressure-flow relation: but quantitative comparisons between the haemoglobin and control curves were not made.…”

Section: Relation To Previous Studiesmentioning

confidence: 99%

Effect of extravascular plasma protein on pressure‐flow relations across synovium in anaesthetized rabbits.

McDonald

Levick

1993

The Journal of Physiology

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SUMMARY1. The effect of extravascular plasma protein on fluid flux through interstitial matrix was investigated in vivo by studying the pressure-flow relation across synovium during intra-articular infusions of protein solutions (usually bovine serum albumin). Synovium is a sheet of non-epithelial cells separated by interstitium-filled gaps, beneath which are fenestrated capillaries: synovium regulates synovial fluid volume and composition.2. Albumin solutions (10-150 g l-) of measured oncotic pressure and viscosity were infused at known pressure into the synovial cavity of knees of anaesthetized rabbits. Flow across the synovial lining in the steady state (absorption rate Q8) was recorded at a series of joint pressures (Ps) to define the pressure-flow relation. Krebs solution was infused into the opposite knee as a control (26 animals).3. Infusion of a low albumin concentration (10 g l-, bovine or rabbit) or diluted rabbit serum revealed no specific effect of plasma protein on interstitial matrix permeability (cf. specific protein effect on capillary glycocalyx permeability). Physiological (22-5 g l-') and higher concentrations reduced trans-synovial absorption rate. The slope of the pressure-flow relation was reduced and the pressure intercept displaced to the right (i.e. P, at zero flow was raised).4. Slope dQo/dP, correlated negatively with intra-articular viscosity (P= 0-001-0-04), in keeping with viscous interstitial flow. The reduction in normalized slope, however, did not equal the reduction in fluidity (1/viscosity) quantitatively. It is proposed that apparent fluidity within the interstitial matrix is higher than in the bulk phase due to steric exclusion of albumin (radius 3-55 nm) by the interstitial glycosaminoglycans. The latter form spaces of estimated mean hydraulic radius 14-18 nm in synovium.5. The joint-pressure intercept at zero net trans-synovial flow was displaced 0.015 cmH20 per cmH20 intra-articular oncotic pressure (nr,; S.E.M. + 0-006). Thus large trans-synovial osmotic gradients were not maintained at physiological flow velocities. The 1-5 % displacement of the P, intercept by nr, was attributed principally to interstitial albumin exerting pericapillary oncotic pressure and enhancing net Starling filtration pressure. Indeed, net trans-synovial flow at low

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“…Although mass transport in tissue culture involves multiple biochemical species, studies focused on other tissue types, such as skin, cartilage, oculartissues, and blood vessels have clearly established the importance of adequate oxygen (Abraham et al, 2013;Ai and Vafai, 2006;Chung and Vafai, ;Chung and Vafai, 2013;de Monte et al, 2013;Denny and Walsh, ;Ethier and Moore, 1997;Gill et al, 2011;Johnson et al, 2009;Kaazempur-Mofrad et al, 2005;Karner and Perktold, 2000;Khakpour and Vafai, 2008;Kumar et al, 2004;Liu et al, 2011;Prosi et al, 2005;Stangeby and Ethier, 2002;Tarbell et al, 1988;Wang et al, 2009) and glucose delivery. (Boubriak et al, 2006;Converti et al, 1996;Day et al, 2013;Gao and Xu, 2011;Koutny, 2011a;Koutny, 2011b;Martineau, 2012;Mokhbi Soukane et al, 2007).…”

Section: Chapter 5: Mass Transport Modelmentioning

confidence: 99%

Movement Effects on the Flow Physics and Nutrient Delivery in Engineered Valvular Tissues

Salinas¹

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The effect of varying albumin concentration of the hydraulic conductivity of the rabbit common carotid artery

Cited by 65 publications

References 17 publications

The effect of luminal flow in rabbit carotid artery on transmural fluid transport

The effect of luminal flow in rabbit carotid artery on transmural fluid transport

Effect of extravascular plasma protein on pressure‐flow relations across synovium in anaesthetized rabbits.

Movement Effects on the Flow Physics and Nutrient Delivery in Engineered Valvular Tissues

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