The effect of vasectomy on the testes of inbred Lewis rats

Neaves, William B.

doi:10.1530/jrf.0.0540405

Cited by 38 publications

(20 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If penetration of aged testicular tubules by lanthanum is a physiologically significant indication of a defective blood-testis barrier, the arrested development of spermatogonia and spermatocytes may be the result of an altered intra-tubular microenvironment. Consistent with this view, Neaves (1978) found lanthanum-permeable 'tight' junctions with reduced sperm production in the testes of vasectomized Lewis rats. However, further explanations of sperm cell attrition must be sought because the integrity of the blood-testis barrier was apparently maintained in the majority of atrophie tubule segments.…”

Section: Discussionsupporting

confidence: 68%

Structure and gametogenic potential of seminiferous tubules in ageing mice

Gosden¹,

Richardson²,

Brown³

et al. 1982

Reproduction

View full text Add to dashboard Cite

The gametogenic potential of young male CBA/Ca mice aged 4-5 months was compared with that of animals 20-23 months of age which had recently ceased to sire offspring. The older mice had substantially lower circulating levels of testosterone and smaller testes. Testicular and epididymal spermatozoa were reduced in number, had more abnormal forms and fewer were progressively motile. Ageing seminiferous tubules varied in the degree of functional atrophy from complete depletion of germ cells to maintenance of sperm production. They were enclosed by a thickened basal lamina and more collagenous connective tissue and occasionally allowed the penetration of lanthanum between Sertoli cells into the ad-luminal compartment. There was no evidence of autosensitization to sperm antigens.

show abstract

Section: Discussionsupporting

confidence: 68%

Structure and gametogenic potential of seminiferous tubules in ageing mice

Gosden¹,

Richardson²,

Brown³

et al. 1982

Reproduction

View full text Add to dashboard Cite

show abstract

“…In contrast to the severe testicular alterations observed in both adult and developing rats with epididymal or efferent duct ligations, changes after vasectomy have been more variable. Lewis rats developed testicular lesions consisting of depletion of germ cells and fusion of spermatids after adult vasectomy (Neaves, 1978;Flickinger et al, 1987;Herr et al, 1987;Chehval et al, 1995), but prepubertal obstruction of the vas deferens did not result in testicular changes (Flickinger et al, 1995), and testicular alterations are less frequent following adult vasectomy in Sprague-Dawley or Wistar strains of rats (Smith, 1962;Flickinger, 1972).…”

Section: Discussionmentioning

confidence: 91%

Degeneration of the seminiferous epithelium following epididymal obstruction in prepubertal rats

et al. 1999

View full text Add to dashboard Cite

The development of the testes was studied in rats following prepubertal obstruction of the epididymis. Male rats received bilateral ligation of the corpus epididymidis or a sham operation at 10 days of age, and temporal changes in testicular morphology and weights of reproductive organs were determined at intervals spanning sexual maturation. Development of the testes was normal through 35 days of age. The initial histological changes in the testes of ligated animals, observed at 56 days, included an increased diameter of the seminiferous tubule lumen, depletion of spermatids, and the presence of multinucleate spermatids. Subsequently, germ cells were greatly depleted in the testes of 91- and 128-day-old rats with ligated epididymides. After puberty, testicular weight and volume declined relative to corresponding sham-operated animals. On the other hand, the weights of the epididymides in ligated animals prior to puberty significantly exceeded those of sham-operated rats but weighed significantly less than those of rats in the sham group after sexual maturation. Testicular alterations occurred after increases in the weights of the epididymides. Testicular changes may have contributed to rather than resulted from an autoimmune response to spermatozoa because testicular alterations preceded increases in antisperm autoantibodies.

show abstract

“…Multinucleated giant cells are common in vasectomy-induced spermatogenic damage, probably as a result of germ cell sloughing, an increase of pressure in the seminiferous tubules and an autoimmune reaction [37,47,51]. A histophysiological study of vasectomized rats indicated that a higher frequency of stage Ⅶ-Ⅷ of the tubular cycle was observed, showing sperm accumulation [25].…”

Section: Discussionmentioning

confidence: 99%

Effect of Short Period Vasectomy on FSH, LH, Inhibin and Testosterone Secretions, and Sperm Motility in Adult Male Rats

et al. 2011

View full text Add to dashboard Cite

The present study was undertaken to clarify changes in secretions of FSH, LH, inhibin and testosterone, and sperm motility after bilateral vasectomy in adult male rats. Bilateral vasectomy was created surgically (treated group) and intact rats were used as control (control group). On days 3,5,7,14,30, 60, and 90 after surgery, plasma concentrations of FSH, LH, inhibin, and testosterone were measured by radioimmunoassay, and sperm motility characteristics were measured by computer-assisted sperm analysis (CASA). The results show that weights of epididymides significantly increased in vasectomized rats as compared to control rats. Histologically, damage to spermatogenesis was observed in vasectomized rats. Multinucleated giant cells were observed in the lumen of some seminiferous tubules, and there were degenerative spermatids in the epididymides of vasectomized rats. Plasma levels of LH, FSH, and testosterone only decreased on day 3 after vasectomy; however, plasma levels of ir-inhibin significantly increased on day 3 after vasectomy. In addition, the sperm motility parameters, straight-line velocity, curvilinear velocity, deviation of the sperm head from the mean trajectory and the maximum amplitude of lateral head displacement were decreased from day 60 after vasectomy. These results suggest that vasectomy reduces sperm motility starting from day 60 after vasectomy, and early bilateral vasectomy does not strongly affect the endocrine function of the testis, though it may result in damage to spermatogenesis in vasectomized rats.

show abstract

The effect of vasectomy on the testes of inbred Lewis rats

Cited by 38 publications

References 16 publications

Structure and gametogenic potential of seminiferous tubules in ageing mice

Structure and gametogenic potential of seminiferous tubules in ageing mice

Degeneration of the seminiferous epithelium following epididymal obstruction in prepubertal rats

Effect of Short Period Vasectomy on FSH, LH, Inhibin and Testosterone Secretions, and Sperm Motility in Adult Male Rats

Contact Info

Product

Resources

About