The effect of vasopressin injection on ovarian reserve in patients with ovarian endometrioma: a randomized controlled trial

Alborzi, Saeed; Poordast, Tahereh; Askary, Elham; Chaman‐Ara, Kefayat; Sorouri, Ziba Zahiri; Kellaii, Elnaz Hosseini Najar; Nahooji, Siavash Pirzadeh

doi:10.1016/j.rbmo.2021.11.024

Cited by 2 publications

(1 citation statement)

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“…Alborzi et al. conducted an RCT to compare ovarian cystectomy after vasopressin injection in the mesovarium space (n=60) and direct cystectomy (n=60) for patients with unilateral OMA (3-6 cm) ( 165 ). The results showed that the control group had significantly higher hemostasis points and bleeding compared with the vasopressin group, but there was no difference between the two groups in postoperative serum levels of AMH and pregnancy outcomes.…”

Section: New Treatment and Target Therapymentioning

confidence: 99%

Impacts of endometrioma on ovarian aging from basic science to clinical management

Tan

Xue

et al. 2023

Front. Endocrinol.

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Endometriosis is a common reproductive disorder characterized by the presence of endometrial implants outside of the uterus. It affects ~1 in 10 women of reproductive age. Endometriosis in the ovary, also known as endometrioma (OMA), is the most frequent implantation site and the leading cause of reproductive failure in affected women. Ovarian aging is one of the characteristic features of OMA, however its underlying mechanism yet to be determined. Accumulated evidence has shown that pelvic and local microenvironments in women with OMA are manifested, causing detrimental effects on ovarian development and functions. Whilst clinical associations of OMA with poor ovarian reserve, premature ovarian insufficiency, and early menopause have been reported. Moreover, surgical ablation, fenestration, and cystectomy of OMA can further damage the normal ovarian reservoir, and trigger hyperactivation of primordial follicles, subsequently resulting in the undesired deterioration of ovarian functions. Nevertheless, there is no effective treatment to delay or restore ovarian aging. This review comprehensively summarised the pathogenesis and study hypothesis of ovarian aging caused by OMA in order to propose potential therapeutic targets and interventions for future studies.

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Section: New Treatment and Target Therapymentioning

confidence: 99%