The effect of venous congestion on the blood clotting system

Egeberg, O.

doi:10.3109/00365516309051305

Cited by 21 publications

(4 citation statements)

References 15 publications

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“…This probably reflects the careful avoidance of contact activation during collection and handling. As observed by Egeberg (1963) it is likely that contact activation rather than difficult venepuncture is the major technical cause for a in vitvo rise in factor VII.…”

Section: Discussionmentioning

confidence: 91%

Factor VII in an Industrial Population

et al. 1974

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Factor-VII levels were measured in members of an industrial population participating in a long-term prospective study of arterial disease. A modified semi-automated method with an artificially prepared factor-VII deficient plasma, one batch of freeze-dried thromboplastin and one freeze-dried pooled reference plasma was used throughout. All calculations were carried out on a programmable desk calculator.Mean factor-VII levels in men and in women never on oral contraceptives were similar (age-adjusted means 95.0% and 92.4% respectively). A very highly significant increase in factor VII was found in women on the low oestrogen contraceptive pill (age-adjusted mean 134.8% compared to 92.4% in women never on oral contraceptives).There was a highly significant rise in factor-VII activity with age in both men and women. In men, factor VII rose 0.45% per year, whereas in women it increased at the rate of 1.1% per year. The difference in the slopes of these regression lines for men and women was significant. At younger ages, the mean levels for women were lower than for men, while at older ages the reverse was true.No relationship with ABO blood groups or secretor status were found. Venepunctures noted as difficult appeared to have no effect on factor-VII levels.Factor VII is the coagulation factor required for the activation of factor X with tissue extracts. Increased levels of factor VII are described in pregnancy (Alexander et al, 1956;Rutherford et al, 1964; Amris & Starup, 1967) and in women on oral contraceptives (Rutherford et al,

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Section: Discussionmentioning

confidence: 91%

Factor VII in an Industrial Population

et al. 1974

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“…Intcrcsting corrclations between the blood coagulation and fibrinolytic mechanisms and the adrenergic systcm can be observed through pharmacological stimulation. Infusion of adrcnalinc in man induces a striking, although transient, increase of factor-VIII plasma level (Marciniak, 1957;higram, 1961;Libre et al, 1968) with a hypercoagulability pattern in the thromboelastogram (Ambanelli et al, 1963) and readily detected activation of fibrinolysis (Biggs et al, 1947;Sherry et al, 1959;Genton et al, 1961;Ambanelli et a!, 1963). These observations suggest that the variations following venous stasis could be mediated by the adrenergic systcm, and the present availability of drugs with a selective blocking effect on alpha-and on bcta-receptors of this system offered the opportunity of an in vivo study in man.…”

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confidence: 99%

Effect of Alpha‐ and Beta‐blocking Drugs on the Clotting and Fibrinolytic Response to Venous Stasis in Man

et al. 1973

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Summary. The changes in coagulability and in fibrinolytic activity induced in local blood by venous stasis in man are not prevented by blocking of alpha‐ and beta‐adrenergic receptors. Administration of l‐propranolol and of l‐propranolol plus phentolamine in adequate doses just before the execution of a tourniquet test failed to inhibit the major changes, i.e. rise in factor‐VIII level, shortening of partial thromboplastin time (PTT) and euglobulin lysis time (ELT), hypercoagulable pattern on thromboelastogram, following venous stasis. Some other clotting tests remained unchanged in all experimental conditions. Physiopathological implications of these results are discussed, taking into account the possible role of the adrenergic system in the control of a postulated equilibrium between blood coagulation and fibrinolysis.

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“…Spöttl Venous occlusion is reported to produce a marked increase in fibrino lytic activity in the blood [1,3,9,17,20,21,25]. Postocclusional release of plasminogen activator (PA) -probably from the vasa vasorum [17,21,25] -seems to counteract hypercoagulability due to stasis, ischemia, concentration of plasma proteins and activation of the intrinsic clotting system [12]. In patients with venous thrombosis Pandolfi et al [25] demonstrated a decreased PA content of the vessel walls and a weak enhancing of fibrinolytic activity by venous oc clusion.…”

Section: Enhancement Of the Fibrinolytic Activity By Venous Occlusionmentioning

confidence: 99%