The Effect of Ventilation on Cerebral Oxygenation. during Hypothermia

I n order to study the relationship between arterial P(:n, and cerebral blood flow (CBF) in hypothermia, the body temperature of artificially ventilated rats was decreased to 22"C, and changes in CBF were evaluated from arteriovenous differences in oxygen content (AVDoe) a t Pace, values of 15, 30, 40 and 60 mm Hg. T h e results were compared to those obtained at normal body temperature (37°C) over the PaCo, range 15-60 mm Hg. Separate experiments were performed to evaluate CBF and ChlRo, at 22°C and a Pa(;o, of 15 mm Hg, using an inert gas technique for CBF. The tissue contents of phosphocreatine, ATP, ADP, AMP and lactate were nicasured in hypothermic animals a t PaCO, values of 15, 30 and 60 mm Hg. T h e results showed that changes in CBF were of the same relative magnitude in hypothermia and normothermia when Pacyj, was increased from about 35 to about 60 mm Hg. However, with a decrease in PaCOe the reduction in CBF was much more pronounced in hypothermia, and at Pa(:(), 15 mm Hg CBF was less than 20 "/o of the value measured in normothcrniic and normocapnic animals. T h e results of the metabolite measurements gave no evidence of tissue hypoxia in spite of the pronounced reduction in CBF. Although the results demonstrate that the brain of a hypotherrnic animal is protected against the harmful effects of a lowered CBF, it may not warrant rccommending hyperventilation in clinical cases of hypothermia, especially not in patients with arteriosclerosis or cerebrovascular diseases.

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Influence of Changes in Arterial P_CO2 on Cerebral Blood Flow and Cerebral Energy State during Hypothermia in the Rat

Hägerdal

Harp

Siesjö

1975

Acta Anaesthesiol Scand

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Literature

2009

Acta Neurologica Scandinavica

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The Effect of Ventilation on Cerebral Oxygenation. during Hypothermia

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Influence of Changes in Arterial P_CO2 on Cerebral Blood Flow and Cerebral Energy State during Hypothermia in the Rat

Influence of Changes in Arterial P_CO2 on Cerebral Blood Flow and Cerebral Energy State during Hypothermia in the Rat

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The Effect of Ventilation on Cerebral Oxygenation. during Hypothermia

Cited by 2 publications

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Influence of Changes in Arterial PCO2 on Cerebral Blood Flow and Cerebral Energy State during Hypothermia in the Rat

Influence of Changes in Arterial PCO2 on Cerebral Blood Flow and Cerebral Energy State during Hypothermia in the Rat

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Influence of Changes in Arterial P_CO2 on Cerebral Blood Flow and Cerebral Energy State during Hypothermia in the Rat

Influence of Changes in Arterial P_CO2 on Cerebral Blood Flow and Cerebral Energy State during Hypothermia in the Rat