The effect of vertebral collapse on spinal bone mineral density measurements in osteoporosis

Ryan, P. J.; Evans, PM; Blake, Glen M.; Fogeman, I

doi:10.1016/0169-6009(92)90812-r

Cited by 48 publications

(13 citation statements)

References 8 publications

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“…Tamoxifen may have estrogen-like effects on bone mineral density and biochemical markers of bone turnover, but only limited or no effect on the occurrence of fractures, or the mechanism of action of tamoxifen on bone metabolism is completely different from that of estrogens. In one investigation it has been shown that bone mineral density may increase although vertebral collapse fractures were seen at the measurement sites [15]. Whether a lower dose of tamoxifen, e.g.…”

Section: Femoral Fractures and Tamoxifen Treatmentmentioning

confidence: 97%

Femoral fractures in postmenopausal breast cancer patients treated with adjuvant tamoxifen

Kristensen

Ejlertsen

Mouridsen

et al. 1996

Breast Cancer Res Tr

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The anti-estrogen tamoxifen is the prevalent endocrine treatment in postmenopausal breast cancer patients. However, nothing is known about the long-term effects of the drug on the skeleton as assessed by the occurrence of fractures. We investigated the occurrence of fractures of the femur in patients from a Danish Breast Cancer Cooperative Group (DBCG) trial initiated in 1977 by a linkage of data from the Danish National Registry of Patients with data from the DBCG registry. 1716 postmenopausal women with high-risk breast cancer were randomized to local radiotherapy with or without tamoxifen, 30 mg daily for 1 year. Fifty-one patients in the control group had one femoral fracture and 64 tamoxifen treated patients had one femoral fracture. Eleven patients in the control group had one trochanteric fracture compared to 27 patients in the tamoxifen group (logrank = 5.28. P = 0.022; hazard ratio = 2.12, 95% CL 1.12, 4.01). The results could not be explained by a longer survival in the tamoxifen group nor by bone metastases with pathological fractures. In conclusion, our study suggests that tamoxifen does not seem to offer protection against fractures in old age and may even increase the risk of fractures at particular sites. This hypothesis needs to be disproved or confirmed in other trials.

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Section: Femoral Fractures and Tamoxifen Treatmentmentioning

confidence: 97%

Femoral fractures in postmenopausal breast cancer patients treated with adjuvant tamoxifen

Kristensen

Ejlertsen

Mouridsen

et al. 1996

Breast Cancer Res Tr

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“…Bone mass of the vertebral body was scored from 0 to 3 [4] according to the trabecular pattern ( Table 3). The fractured vertebrae were excluded from the assessment of osteoporosis so as not to cause misinterpretation of a falsely elevated bone mass [5].…”

Section: Osteoarthritis Methodsmentioning

confidence: 99%

The relationship between osteoarthritis and osteoporosis in the spine

1998

Clin Rheumatol

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The degree of osteoarthritis and osteoporosis in the lumbar spine has been compared in patients with spinal osteoarthritis and osteoporotic fractures and in a normal control group of 252 elderly subjects, to investigate the relationship between osteoarthritis and osteoporosis in the spine. The two indices were highly significantly different in the three groups (p<0.01). The degree of osteoarthritis in the osteoarthritic patients was higher (p<0.01) than in the fracture patients and the normal control subjects, while the degree of osteoporosis in the fracture patients was higher than in osteoarthritic patients and normal controls (p<0.01). These data support the conclusion that osteoarthritis and osteoporosis in the spine are inversely related.

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“…34 Insufficiency fractures of the spine are a common finding in patients undergoing DEXA 42 and have dual significance: (1) the presence of an insufficiency fracture is an important independent factor in the overall fracture risk assessment and (2) fractured vertebral bodies should be omitted from the ROI as their presence will result in an artifactual increase in the reported BMD. 43 Fractures do not change the amount of calcification present within vertebrae; however, loss of height leads to a relative concentration of bone resulting in an absolute increase in the areal bone density. Vertebral fractures are easily recognized on DEXA images owing to the loss of vertebral body height coupled with a sclerotic appearance 2 ( Fig.…”

Section: Osseous Conditions With Focal Increase In Bmd Measurementsmentioning

confidence: 98%

Artifacts and Incidental Findings Encountered on Dual-Energy X-Ray Absorptiometry: Atlas and Analysis

Martineau

Bazarjani

Zuckier

2015

Seminars in Nuclear Medicine

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The effect of vertebral collapse on spinal bone mineral density measurements in osteoporosis

Cited by 48 publications

References 8 publications

Femoral fractures in postmenopausal breast cancer patients treated with adjuvant tamoxifen

Femoral fractures in postmenopausal breast cancer patients treated with adjuvant tamoxifen

The relationship between osteoarthritis and osteoporosis in the spine

Artifacts and Incidental Findings Encountered on Dual-Energy X-Ray Absorptiometry: Atlas and Analysis

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