The effect of vigorous running and cycling on serum COMP, lubricin, and femoral cartilage thickness: a pilot study

Abstract

In the absence of ultrasonographic knee cartilage deformation, the response of serum lubricin and COMP following acute vigorous exercise indicates an increase in joint lubrication and cartilage metabolism, respectively, which appears largely independent of exercise modality.

The effect of aerobic walking and lower body resistance exercise on serum COMP and hyaluronan, in both males and females

“…Serum COMP was analysed using a commercially available sandwich ELISA (Human COMP ELISA kit KA0021, Abnova Corporation, Taiwan) as previously described (Law et al 2015;Roberts et al 2016).…”

“…For example, elevated serum COMP in response to exercise have been associated with decreases in cartilage volume in healthy trained runners (Kersting et al 2005) and a long-term reduction in cartilage thickness in patients with OA (osteoarthritis) (Erhart-Hledik et al 2012). We have previously demonstrated a comparable transient increase in cartilage oligomeric matrix protein (COMP) and lubricin, (biomarkers associated with cartilage catabolism/metabolism and lubrication, respectively) in response to a single bout of approximately 40 minutes of weight bearing exercise (running) and non-weight bearing exercise (cycling) (Roberts et al 2016). Taken together, these findings suggest that an acute increase in serum COMP and lubricin is a normal healthy response to exercise, but that a minimal difference exists in the response to aerobic weight bearing and aerobic nonweight bearing exercise.…”

Knee osteoarthritis and aquatic cycling

“…After correction of the incorrect record, all following records will be checked until successive records free of inconsistencies are found. 92 All data on paper will be stored in a locked archive for a maximum of 15 years. Only the programme coordinator has access to personal data.…”

“…Additionally, research on the effect of exercise on cartilage health and serum biomarkers is still in its infancy. 92 Research in humans and rats suggests that tibiofemoral cartilage might be responsive to aquatic training, 81,93 but further research is required to better understand the exercise induced responses of cartilage and its clinical relevance. Likewise, muscle strength is an important contributor to the improvement of knee pain and physical function, 94,95 but whether aerobic cycling interventions can achieve increases in muscle strength remains unclear.…”

Análise da estrutura e padrão de expressão de lubricina, SMAD2 fosforilada na cadeia de ligação e colágeno tipo I na cartilagem articular da mandíbula durante o envelhecimento

“…Em humanos, a concentração de lubricina sérica aumenta em indivíduos saudáveis submetidos a exercícios de corrida e ciclismo 120 .…”