The Effect of Viola odorata Flower Syrup on the Cough of Children With Asthma

Abstract

This study aimed to investigate the effect of violet syrup on cough alleviation in children with intermittent asthma. In a parallel, double-blind, randomized controlled trial, 182 children aged 2 to 12 years with intermittent asthma were randomly assigned 1:1 to receive violet syrup or placebo along with the common standard treatments in both groups (short-acting β-agonist). Both groups were evaluated in terms of the duration until cough suppression was achieved. No significant difference was observed in basic characteristics. The duration lasting to yield more than 50% cough reduction and 100% cough suppression was significantly less in the violet syrup group compared to placebo (P = .001, P < .001, respectively). There was no significant difference in therapeutic effects between boys and girls. There was a significant inverse correlation between the age of children and rate of cough alleviation and suppression by violet syrup. This study showed that the adjuvant use of violet syrup with short-acting β-agonist can enhance the cough suppression in children with intermittent asthma.

A Critical Review on Phytochemistry, Pharmacology of Viola odorata L. and Related Multipotential Products in Traditional Persian Medicine

“…odorata syrup from flowers on suppression and alleviation of cough in children with intermittent asthma has been evaluated recently. Accordingly, this product was more effective than placebo and could be introduced as an adjuvant along with short‐acting β‐agonists (Qasemzadeh et al, ).…”

Use of complementary and alternative medicine among paediatric patients with hepatogastrointestinal diseases

“…Complementary and alternative medicine is commonly used in the Iranian population, especially herbal medicine (12,13). Several studies have been done on the pattern and associated factors of CAM use in different diseases, and prevalence ranged from 10% to 67%.…”

Clinical validation of efficacy and safety of herbal cough formulation “Honitus syrup” for symptomatic relief of acute non-productive cough and throat irritation

“…Honitus syrup comprises goodness of ayurvedic herbs such as Tulsi ( O. sanctum Linn. ),[ 5 ] Mulethi ( G. glabra Linn),[ 6 ] Banaphsa ( V. odorata Linn),[ 7 ] Shunthi ( Z. officinale Roscoe),[ 8 ] Vasaka ( A. vasica Nees)[ 9 ] and Pippali ( P. longum Linn. ),[ 10 ] which have been used traditionally for their benefits in respiratory health.…”

“…[ 29 ] As per published clinical studies, V. odorata was found to alleviate cough in children with intermittent asthma. [ 7 ] A. vasica is found to be beneficial in respiratory conditions such as asthma/dyspnea, cough, phthisis, and hoarseness of voice. [ 30 ] Antitussive effects of A. vasica extract have been reported similar to codeine in mechanically and electrically induced coughing in rabbits and guinea-pigs on oral administration.…”

“…Honitus Cough Syrup (Mfd by Dabur India Limited) is a proprietary honey-based Ayurvedic herbal, cough syrup formula comprising goodness of herbs such as Tulsi ( Ocimum sanctum Linn. ),[ 5 ] Mulethi ( Glycyrrhiza glabra Linn),[ 6 ] Banaphsa ( Viola odorata Linn),[ 7 ] Shunthi ( Zingiber officinale Roscoe),[ 8 ] Vasaka ( Adhatoda vasica Nees)[ 9 ] and Pippali ( Piper longum Linn. )[ 10 ] which has been reported to provide effective relief in cough without causing adverse effects like those associated with the use of antihistamines.…”