The effect of vitamin B6 on dexamethasone-induced depression in mice model of despair

Mesripour, Azadeh; Alhimma, Fatima; Hajhashemi, Valiollah

doi:10.1080/1028415x.2018.1442184

Cited by 30 publications

(23 citation statements)

References 24 publications

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“…Pyridoxamine, one form of vitamin B6, is important for synthesis of many neurotransmitters such as GABA, serotonin, dopamine, noradrenaline, histamine, glycine, and d-serine, and currently used as therapeutics for autism 30 . It also has been reported that vitamin B6 administration attenuates depression-like behaviors in dexamethasone-induced depression model mice 31 . In addition, β-alanine administration has been reported to improve behaviors of depression in post-traumatic stress disorder (PTSD) model mice by increasing carnosine levels in the brain and maintaining hippocampal BDNF expression, an important target of antidepressants 32 , 33 .…”

Section: Discussionmentioning

confidence: 93%

Decrease of α-defensin impairs intestinal metabolite homeostasis via dysbiosis in mouse chronic social defeat stress model

Suzuki

Nakamura

Shimizu

et al. 2021

Sci Rep

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Psychological stress has been reported to relate to dysbiosis, imbalance of the intestinal microbiota composition, and contribute to the onset and exacerbation of depression, though, underlying mechanisms of psychological stress-related dysbiosis have been unknown. It has been previously established that α-defensins, which are effector peptides of innate enteric immunity produced by Paneth cells in the small intestine, play an important role in regulation of the intestinal microbiota. However, the relationship between disruption of intestinal ecosystem and α-defensin under psychological stress is yet to be determined. Here we show using chronic social defeat stress (CSDS), a mouse depression model that (1) the exposure to CSDS significantly reduces α-defensin secretion by Paneth cells and (2) induces dysbiosis and significant composition changes in the intestinal metabolites. Furthermore, (3) they are recovered by administration of α-defensin. These results indicate that α-defensin plays an important role in maintaining homeostasis of the intestinal ecosystem under psychological stress, providing novel insights into the onset mechanism of stress-induced depression, and may further contribute to discovery of treatment targets for depression.

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Section: Discussionmentioning

confidence: 93%

Decrease of α-defensin impairs intestinal metabolite homeostasis via dysbiosis in mouse chronic social defeat stress model

Suzuki

Nakamura

Shimizu

et al. 2021

Sci Rep

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“…This was proven earlier since it was shown that Dex dose dependently increased the immobility time during the FST. 20 By adding the Syn mixture the immobility time in the FST was reduced not only when Dex was injected as single dose but also when it was administered for seven days. This showed that Syn mixture could have preventive effects on Dex induced mental disorders.…”

Section: Discussionmentioning

confidence: 99%

“…19 Furthermore, administration of dexamethasone (Dex) and corticosterone have produced depression-like behaviors in animal models. 20,21 Previously the antidepressant effects of a synbiotic (Syn; probiotic + prebiotic) mixture was proved in animal model of depression. 22 The mixture was chosen on the basis that Lactobacilli and Bifidobacteria have antidepressant effects in animal studies thus a manufactured premixed product was chosen that comprised these genus and also a prebiotic, fructo-oligosaccharides.…”

Section: Introductionmentioning

confidence: 99%

A synbiotic mixture ameliorated depressive behavior induced by dexamethasone or water avoidance stress in mice model

Mesripour¹,

rakhshankhah²

2019

tjps

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Objective: Stress and glucocorticoid drugs disrupts the hypothalamic-pituitary-adrenal axis that is one major causes of depression. The benefits of probiotics may extend to systems beyond the gastrointestinal tract; i.e. the central nervous system. Thus, a synbiotic (probiotic+prebiotic) mixture effect was investigated on dexamethasone (Dex) and stress induced depression. Methods: Male albino mice were used, the forced swimming test (FST) measured despair, while sucrose preference test measured anhedonia. The synbiotic regimen (12.5 × 10 6 CFU) was inserted in drinking water for 7 days. Dex was administered subcutaneously either single-dose on the test day or for 7 days. Water avoidance stress (WAS) induction, 1 hour each day for 4 days. Results: Drinking synbiotic reduced the immobility time during FST (54±7 sec vs, 111±6 sec water group, p<0.001). Dex injection significantly increased the immobility time (single-dose=166±6 sec, and 7 day=174±9 sec) compared to the control groups, while adding synbiotic to their drink reduced it (single dose= 81 ± 6.6 sec, and 7 days= 84 ± 14 sec), indicating that synbiotic reversed Dex induced depression. WAS increased immobility time (148±11 sec, vs sham 99±6 sec, p<0.001) in FST test, by adding the synbiotic treatment following WAS, the immobility time decreased (81 ± 6.5 sec).The synbiotic groups also had a higher percentage of sucrose preference. Conclusion: The synbiotic mixture prevented the effects of WAS, acute or sub-acute Dex induced depression in mice. Therefore, probiotics might be useful and safe supplements to prevent depression related to stress or glucocorticoid therapies that deserves further evaluation.

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“…The model was established based on previous glucocorticoid‐induced depression (Kv et al, ; Mesripour, Alhimma, & Hajhashemi, ) and had been slightly modified. Sixty mice were randomly divided into control and CORT groups.…”

Section: Methodsmentioning

confidence: 99%

Long‐term stability and characteristics of behavioral, biochemical, and molecular markers of three different rodent models for depression

et al. 2019

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Objective:The present study was designed to explore the long-term differences between three mouse models for depression. Method:In the present study, the unpredictable chronic mild stress (UCMS) model, the glucocorticoid/corticosterone model, and the olfactory bulbectomy model were compared at two, three, and five weeks after model induction. Behavioral testing performed included forced-swimming, tail suspension, open-field and elevated plusmaze tests. In addition, 5-hydroxytryptamine (5-HT) and dopamine levels, and mRNA and protein expressions related to 5-HT synthesis, transport, and signaling were analyzed in the hippocampus of tested animals. Results:Our results revealed that each model demonstrated a specific profile of markers, whereas the stability of them differed over testing time. Conclusions:Each model provided a unique set of advantages that can be considered depending on the context and aims of each study. Among the three models, the UCMS model was mostly stable and appeared to the best model for testing long-term depression-like state. K E Y W O R D S 5-HT, corticosterone, depression model, glucocorticoid, olfactory bulbectomy, UCMS How to cite this article: Zhu H, Tao Y, Wang T, et al. Long-term stability and characteristics of behavioral, biochemical, and molecular markers of three different rodent models for depression. Brain Behav. 2020;10:e01508. https ://doi.

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The effect of vitamin B6 on dexamethasone-induced depression in mice model of despair

Abstract: Vitamin B6 prevented DEX-induced depression possibly by altering the GR function. Thus Vitamin B6 could be promising in patients suffering from GC-induced psychiatric adverse effects and probably controlling stress and preventing its affective disorder out comes.

Cited by 30 publications

References 24 publications

Decrease of α-defensin impairs intestinal metabolite homeostasis via dysbiosis in mouse chronic social defeat stress model

Decrease of α-defensin impairs intestinal metabolite homeostasis via dysbiosis in mouse chronic social defeat stress model

A synbiotic mixture ameliorated depressive behavior induced by dexamethasone or water avoidance stress in mice model

Long‐term stability and characteristics of behavioral, biochemical, and molecular markers of three different rodent models for depression

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