The effect of vitamin C supplementation on lipid profile of type 2 diabetic patients: a systematic review and meta-analysis of clinical trials

Tareke, Amare Abera; Hadgu, Addis Alem

doi:10.1186/s13098-021-00640-9

Cited by 15 publications

(10 citation statements)

References 44 publications

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“…Previous studies show that supplementation of zinc (Ranasinghe et al 2015), vitamin-B3 (niacin) (McKenney 2004), and vitamin-D (Jafari et al 2016) improve cholesterol levels, suggesting the possibility that those who take these vitamin/mineral supplements are less likely to be diagnosed with dyslipidemia. But there seems to be no adequate evidence to support vitamin C and vitamin E supplementation for dyslipidemia (Hendarto et al 2019;Tareke and Hadgu 2021). We did not find any studies that demonstrated that vitamin/mineral supplementation increased the incidence of dyslipidemia.…”

Section: Taking Vitamin/mineral Supplementsmentioning

confidence: 54%

Who Are Free from Hypertension, Dyslipidemia, and Diabetes Mellitus in the Middle-Aged and Elderly Population of Japan?

Sekizawa

Konishi

2021

Economics, Law, and Institutions in Asia Pacific

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In the present study, we explored who are more (less) likely to be diagnosed with mild lifestyle-related diseases (MLDs) defined as hypertension, dyslipidemia, and diabetes mellitus as a whole among middle-aged and elderly persons. Data from 11 years of the Longitudinal Survey of Middle-Aged and Elderly Persons by the Japanese Ministry of Health, Labour and Welfare were used for the analyses. A complementary log-log model was chosen for the analyses. For men, those who drink alcohol were more likely to be diagnosed with MLDs. Former smokers were more likely to be diagnosed with MLDs than current smokers. Men who perform light exercise four days or more per week or those who perform vigorous exercise one to three days per week were less likely to be diagnosed with MLDs than those who did not exercise or exercised about one day per month. Men who take care of eating amounts were more likely to be diagnosed with MLDs. Men who brush teeth after meals were less likely to be diagnosed with MLDs. For women, those who drink alcohol were less likely to be diagnosed with MLDs. Former smokers were more likely to be diagnosed with MLDs than current smokers. Women who perform moderate exercise four days or more per week were more likely to be diagnosed with MLDs than those who did not exercise or exercised about one day per month. Women who take care of their eating amount or take vitamin/mineral supplements were more likely to be diagnosed with MLDs. Women who eat a variety of foods or maintain appropriate body weight levels were less likely to be diagnosed with MLDs. Some of these results are inconsistent with previous studies, are contrary to current understanding, or are not well known. Hence, further studies with a greater focus on causal relationships are required.

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Section: Taking Vitamin/mineral Supplementsmentioning

confidence: 54%

Who Are Free from Hypertension, Dyslipidemia, and Diabetes Mellitus in the Middle-Aged and Elderly Population of Japan?

Sekizawa

Konishi

2021

Economics, Law, and Institutions in Asia Pacific

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“…At least partly based on its antioxidant properties, AA has been considered as a complementary nutritional treatment for T2DM. However, evidence for the significance and beneficial effect of AA in T2DM has thus far been inconclusive [ 8 , 9 ]. We suspect that one reason for this inconclusive evidence is that combined genetic and dietary factors may greatly influence AA effects on metabolism.…”

Section: Discussionmentioning

confidence: 99%

“…WAT actively regulates whole-body energy homeostasis by storing lipids and secreting adipokines [ 6 ], and HFD-induced obesity is typically associated with increased fat deposition in WAT, induction of WAT inflammation, dysregulation of adipokines, ectopic fat accumulation, and finally T2DM [ 7 ]. However, clinical trials examining the effects of AA on T2DM have thus far been inconclusive [ 8 , 9 ]. We suspect that beneficial effects of AA on metabolism might be influenced by combinations of genetic and environmental factors.…”

Section: Introductionmentioning

confidence: 99%

Vitamin C attenuates predisposition to high-fat diet-induced metabolic dysregulation in GLUT10-deficient mouse model

2022

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Background The development of type 2 diabetes mellitus (T2DM) is highly influenced by complex interactions between genetic and environmental (dietary and lifestyle) factors. While vitamin C (ascorbic acid, AA) has been suggested as a complementary nutritional treatment for T2DM, evidence for the significance and beneficial effects of AA in T2DM is thus far inconclusive. We suspect that clinical studies on the topic might need to account for combination of genetic and dietary factors that could influence AA effects on metabolism. In this study, we tested this general idea using a mouse model with genetic predisposition to diet-induced metabolic dysfunction. In particular, we utilized mice carrying a human orthologous GLUT10G128E variant (GLUT10G128E mice), which are highly sensitive to high-fat diet (HFD)-induced metabolic dysregulation. The genetic variant has high relevance to human populations, as genetic polymorphisms in glucose transporter 10 (GLUT10) are associated with a T2DM intermediate phenotype in nondiabetic population. Results We investigated the impacts of AA supplementation on metabolism in wild-type (WT) mice and GLUT10G128E mice fed with a normal diet or HFD. Overall, the beneficial effects of AA on metabolism were greater in HFD-fed GLUT10G128E mice than in HFD-fed WT mice. At early postnatal stages, AA improved the development of compromised epididymal white adipose tissue (eWAT) in GLUT10G128E mice. In adult animals, AA supplementation attenuated the predisposition of GLUT10G128E mice to HFD-triggered eWAT inflammation, adipokine dysregulation, ectopic fatty acid accumulation, metabolic dysregulation, and body weight gain, as compared with WT mice. Conclusions Taken together, our findings suggest that AA has greater beneficial effects on metabolism in HFD-fed GLUT10G128E mice than HFD-fed WT mice. As such, AA plays an important role in supporting eWAT development and attenuating HFD-induced metabolic dysregulation in GLUT10G128E mice. Our results suggest that proper WAT development is essential for metabolic regulation later in life. Furthermore, when considering the usage of AA as a complementary nutrition for prevention and treatment of T2DM, individual differences in genetics and dietary patterns should be taken into account.

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“…Although observational evidence suggested that serum vitamin C was associated with reduced BP [38,39], meta-analysis of trials found no effects of vitamin C supplementation on BP [40]. Furthermore, recent meta-analyses of randomized trials found that vitamin C supplementation was not associated with TC, TG, LDL, HDL [40][41][42], glucose, HbA1c and insulin [40,43], in line with the findings from multiple MR studies that circulating vitamin C level did not change lipids, BMI, BP [44] and glycemic traits [45]. For vitamin E, MR evidence showed that circulating vitamin E was not associated with BMI, or glucose traits [46].…”

Section: Discussionmentioning

confidence: 99%

Vegetable intake and metabolic risk factors: A Mendelian randomization study

Bešević²

2022

Preprint

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Background: The associations between vegetable intake and metabolic risk factors remain inconsistent. This study was aimed to investigate the association between cooked and raw vegetable intake with serum lipids, body mass index (BMI), blood pressure and glycemic traits. Methods: This was a two sample Mendelian randomization study. Nine and 19 genetic variants were identified from genome wide association studies (GWAS) as instrumental variables for cooked and raw vegetable intake. Summary level statistics were used from GWAS of total cholesterol, triglycerides, high density lipoprotein, low density lipoprotein, systolic blood pressure, diastolic blood pressure, BMI, fasting glucose, fasting insulin, glycated haemoglobin and 2 hour glucose after oral glucose tolerance test. Multivariable MR with inverse variance weighted method was performed as primary analysis, while median-based method and MR Egger method were performed as sensitivity analyses. Results: Vegetable intake was not associated with total cholesterol (-0.06 [-0.30, 0.18] and -0.02 [-0.20, 0.16] for each serving increase of cooked and raw vegetable intake) and triglyceride (-0.12 [-0.36, 0.13] and 0.03 [-0.15, 0.22]). Null evidence was observed for associations between vegetable intake and lipoproteins, blood pressure, BMI, insulin and glycemic measures. Sensitivity analyses generated similar null associations. Conclusions: We found null association between vegetable intake and metabolic risk factors. This is consistent with previous MR findings of null associations between diet-derived antioxidants and metabolic risk factors.

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The effect of vitamin C supplementation on lipid profile of type 2 diabetic patients: a systematic review and meta-analysis of clinical trials

Cited by 15 publications

References 44 publications

Who Are Free from Hypertension, Dyslipidemia, and Diabetes Mellitus in the Middle-Aged and Elderly Population of Japan?

Who Are Free from Hypertension, Dyslipidemia, and Diabetes Mellitus in the Middle-Aged and Elderly Population of Japan?

Vitamin C attenuates predisposition to high-fat diet-induced metabolic dysregulation in GLUT10-deficient mouse model

Vegetable intake and metabolic risk factors: A Mendelian randomization study

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