The effect of vitamin C on antigen-induced bronchospasm

Kordansky, Daniel W.; Rosenthal, Richard R.; Norman, Philip S.

doi:10.1016/0091-6749(79)90163-5

Cited by 40 publications

(9 citation statements)

References 13 publications

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“…The results of antioxidant supplementation trials in asthma to date are variable. Vitamin C improved asthma outcomes in some trials ( 40 – 42 ) , but not others ( 43 – 45 ) . Vitamin E supplementation showed no clinical asthma benefit ( 46 ) .…”

Section: Discussionmentioning

confidence: 96%

Reduced circulating antioxidant defences are associated with airway hyper-responsiveness, poor control and severe disease pattern in asthma

Wood

Gibson

2009

Br J Nutr

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Dietary antioxidants are important in protecting against oxidative stress. We have previously demonstrated that circulating dietary antioxidant levels are reduced in asthma. The present study examined the variation in dietary antioxidant levels in asthma, according to airway responsiveness, asthma control and clinical asthma pattern. Peripheral blood was collected from forty-one subjects with stable, persistent asthma. Airway responsiveness was assessed by hypertonic saline challenge. Asthma control was assessed using the Asthma Control Questionnaire. Clinical asthma pattern was determined using Global Initiative for Asthma (GINA) criteria. Whole-blood carotenoids (β-carotene, lycopene, α-carotene, β-cryptoxanthin, lutein/zeaxanthin) and tocopherols (α-, δ-, γ-tocopherol) were measured by HPLC. Plasma antioxidant potential (AOP) was determined by colorimetric assay (OxisResearch, Portland, OR, USA). Asthmatic subjects with airway hyper-responsiveness (AHR) had reduced levels of β-carotene and α-tocopherol compared with those without AHR. Subjects with uncontrolled asthma had low levels of AOP compared with those with controlled or partly controlled asthma. Subjects with a severe persistent clinical asthma pattern had reduced levels of α-tocopherol compared with those with a mild to moderate asthma pattern. We conclude that asthmatic subjects with AHR, uncontrolled asthma and a severe asthma pattern have impaired antioxidant defences and are thus most susceptible to the damaging effects of oxidative stress. This highlights the potential role for antioxidant supplementation in these subjects.

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Section: Discussionmentioning

confidence: 96%

Reduced circulating antioxidant defences are associated with airway hyper-responsiveness, poor control and severe disease pattern in asthma

Wood

Gibson

2009

Br J Nutr

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“…A study of short-term supplementation with vitamin C demonstrated decreased bronchial reactivity to methacholine in asthmatic subjects, 89 although another study showed no beneficial effect on antigen-induced bronchoconstriction of 7 days of supplementation with vitamin C. 90 However, supplementation with a combination of vitamins C, E and β-carotene resulted in a significant protective effect on lung function in street workers exposed to high ozone concentrations in Mexico City, and in the same city, supplementation with vitamins C and E reduced the adverse effect of ozone exposure on the airways of asthmatic children. 91,92 Similarly, vitamin C and E supplements provided partial protection against the acute effects of ozone on lung function in a group of Dutch cyclists, 93 and in adults with asthma.…”

Section: Vitamins C and Ementioning

confidence: 99%

Oxidative stress and antioxidant deficiencies in asthma: potential modification by diet

Misso

Thompson

2005

Redox Report

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The lungs of asthmatic patients are exposed to oxidative stress due to the generation of reactive oxygen and nitrogen species as a consequence of chronic airway inflammation. Increased concentrations of NO*, H2O2 and 8-isoprostane have been measured in exhaled breath and induced sputum of asthmatic patients. O2*-, NO*, and halides interact to form highly reactive species such as peroxynitrite and HOBr, which in turn cause nitration and bromination of protein tyrosine residues. Oxidative stress may also reduce glutathione levels and cause inactivation of antioxidant enzymes such as superoxide dismutase, with a consequent increase in apoptosis, shedding of airway epithelial cells and airway remodelling. The oxidant/antioxidant equilibrium in asthmatic patients may be further perturbed by low dietary intakes of the antioxidant vitamins C and E, selenium and flavonoids, with a consequent lowering of the concentrations of these and other non-dietary antioxidants such as bilirubin and albumin in plasma and airway epithelial lining fluid. Although supplementation with vitamins C and E appears to offer protection against the adverse effects of ozone, recent randomised, placebo-controlled trials of vitamin C or E supplements for patients with mild asthma have not shown significant benefits over standard therapy. However, genetic variation in glutathione S-transferase may influence the susceptibility of asthmatic individuals to oxidative stress and the extent to which they are likely to benefit from antioxidant supplementation. Long-term prospective trials are required to determine whether modification of dietary intake will benefit asthma patients and reduce the socio-economic burden of asthma in the community.

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“…46 Al igual que este, otros estudios reportaron que no existe evidencia sufi ciente para incluir a la vitamina C en el tratamiento del asma. 45,47,48 En cuanto al asma inducida por ejercicio (AIE), se ha especulado que la combinación del ácido ascórbico con vitamina E brinda mayor benefi cio que la ad- OH HO HO ministración de estas vitaminas por separado. 49 Sin embargo, no existe evidencia contundente del benefi cio de la administración concomitante de estos nutrientes en el AIE.…”

Section: Vitamina Cunclassified

Vitaminas antioxidantes en asma

Barrera-Mendoza

Ayala-Mata

Cortés‐Rojo

et al. 2018

RAM

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Asthma is a condition of unknown etiology characterized by chronic airway inflammation. Cells that mediate the inflammatory response generate reactive oxygen species that, together with other respiratory tract naturally-occurring oxidant species, produce a rupture of the redox balance, generating oxidative stress. It has been proposed that oxidative stress can be reverted by supplemental or dietary intake of antioxidant vitamins such as vitamin A, C, D and E, and this way relieve, improve or protect people with asthma. In this research, observational and placebo-controlled trials with regard to the role of antioxidant vitamins in the course of asthma, published between 1979 and 2016, were reviewed. The search engines were Google and Google Scholar, whereas consulted databases were PubMed and The Cochrane Library. There were 75 articles relevant to the subject that were found and reviewed, and it was concluded that it is not clear if the intake of supplements of these vitamins has any beneficial clinical effect on asthma control. Further controlled, longer trials are needed to elucidate the role of these nutrients in the course of asthma.

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The effect of vitamin C on antigen-induced bronchospasm

Cited by 40 publications

References 13 publications

Reduced circulating antioxidant defences are associated with airway hyper-responsiveness, poor control and severe disease pattern in asthma

Reduced circulating antioxidant defences are associated with airway hyper-responsiveness, poor control and severe disease pattern in asthma

Oxidative stress and antioxidant deficiencies in asthma: potential modification by diet

Vitaminas antioxidantes en asma

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