The Effect of Vitamin D Supplementation in Children With Asthma: A Meta-Analysis

Hao, Meiqi; Xu, Ruoxin; Luo, Nachuan; Liu, Miaowen; Xie, Junping; Zhang, Wen‐Xiong

doi:10.3389/fped.2022.840617

Cited by 9 publications

(5 citation statements)

References 36 publications

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“…No significant adverse events related to supplementation were reported during the study, indicating that vitamin D supplementation at the provided dosage (1000 IU per day) was well-tolerated and did not cause any harm to the participants. Although this study has yielded encouraging results, some limitations need to be acknowledged 12 . First, the study's duration was limited to 12 weeks, and long-term effects of vitamin D supplementation were not explored.…”

Section: Discussionmentioning

confidence: 91%

“…Vitamin D, a fatsoluble secosteroid, has gained considerable attention for its potential immunomodulatory and anti-inflammatory effects. Numerous studies have explored the relationship between vitamin D status and asthma outcomes in children, raising the question of whether vitamin D supplementation could play a role in improving asthma control 1 .…”

Section: Introductionmentioning

confidence: 99%

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The Impact of Vitamin D Supplementation on Asthma Control in Children

Bashir,

Rafaqat,

Lodhi

et al. 2023

PJMHS

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Introduction: Asthma is a common chronic respiratory condition affecting millions of children worldwide. Despite advancements in asthma management, many pediatric patients continue to experience suboptimal control, leading to frequent exacerbations, reduced quality of life, and increased healthcare utilization. Objectives: The main objective of the study is to find the impact of vitamin D supplementation on asthma control in children. Material and methods: A total of 175 pediatric patients aged 6 to 14 years were recruited from the pediatric respiratory clinic at Nawaz Sharif Medical College, Gujrat. Eligible participants were diagnosed with persistent asthma according to the Global Initiative for Asthma (GINA) guidelines. Patients with significant comorbidities, those on vitamin D supplementation, or with a history of vitamin D toxicity were excluded from the study. Results: The study enrolled a total of 175 pediatric patients, with 87 participants in the intervention group and 88 in the control group. The mean age of the participants was 10 years, with a gender distribution of 55% male and 45% female. Baseline characteristics, including age, gender, and asthma severity, were comparable between the two groups. At baseline, the mean ACT score in the intervention group was 14.9, while in the control group, it was 14.7. The mean cACT score was 16.8 in the intervention group and 17.1 in the control group. Practical Implication: This study will be helpful in finding the vitamin D supplementation on asthma control in children. Conclusion: It is concluded that the impact of vitamin D supplementation on asthma control in children provides encouraging evidence for the potential benefits of vitamin D as an adjunctive therapy in pediatric asthma management. The 12-week intervention with daily vitamin D3 supplementation at a dosage of 1000 IU demonstrated significant improvements in asthma control scores and lung function parameters (FEV1 and FVC) in the intervention group compared to the control group. Keywords: Vit-D, Asthma, Patients, Functions

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

The Impact of Vitamin D Supplementation on Asthma Control in Children

Bashir,

Rafaqat,

Lodhi

et al. 2023

PJMHS

View full text Add to dashboard Cite

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“…Similarly, a study by Thakur et al [ 24 ] showed no difference in FEV1 value among analyzed groups. Other meta-analysis by Hao et al [ 45 ] presents an increase in C-ACT score in vitamin D and control groups, as well as lack of impact on FEV1 and FVC% (forced vital capacity) values.…”

Section: Discussionmentioning

confidence: 99%

Relationship between vitamin D and asthma from gestational to adulthood period: a meta-analysis of randomized clinical trials

Sobczak

Pawliczak

2023

BMC Pulm Med

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Background Despite numerous studies investigating vitamin D, its impact on asthma is still unknown. The aim of our meta-analysis is to analyze the vitamin D supplementation influence on asthma prevention and treatment ranging from gestational to adulthood period. Methods Fifteen randomized clinical trials were included after database search. Studies contained the analyzed endpoints: the number of asthma and wheezing occurrence in gestational and infantile periods, the change of childhood/adult asthma control test score and forced expiratory volume in one second (FEV1) in childhood and adulthood periods. Random effects model was used to calculate effect sizes. Results Supplementation by women during pregnancy period decreased the wheezing occurrence in their children by 23% (RR = 0.77; 95% CI [0.64; 0.92]; p < 0.0049, I2 = 0%); whereas had no effect on given asthma parameters during the infantile period. Moreover, vitamin D administration had negative effect on the FEV1 change in children (MD = -3.84; 95% CI [-7.68; -0.01]; p = 0.0497; I2 = 95%), but had positive effect on the change of ACT score in adults (MD = 1.80; 95% CI [0.12; 3.49]; p = 0.0359; I2 = 99%). Conclusions Our meta-analysis showed the varying results depending on patient's life period. It is important to further investigate the role of vitamin D supplementation in asthma management.

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“…Moreover, they report that vitamin D supplementation may impar patients' lung function-reduce FEV1 and FVC% in comparison to placebo groups. 25 Although clinical trials do not show this effect clearly in patients, vitamin D, through VDRs, influences the smooth muscle cells and inhibits their contraction and remodelling. It 26 Overall, most findings seem to be contradictory and more high quality clinical trials are necessary to further explore potential benefits derived from supplementation of vitamin D in patients with asthma.…”

Section: Vitamin Dmentioning

confidence: 99%

Role of dietary supplements in the treatment of asthma - a narrative review

Kozicz,

Kołodziej,

Saiuk

et al. 2024

J Educ Health Sport

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Introduction: Asthma is a common inflammatory disease of airway affecting both adults and children. In a large number of cases asthma remains poorly controlled. There is a need to find an additional therapeutic demeanour alleviating symptoms and lowering the risk complications in a long-term. Recently, increasing number of studies has been examining dietary supplements in regards to their anti-inflammatory, immunomodulatory, anti-remodelling properties and their use in asthmatic patients. Aim of the Study: The aim of the study was to collect and analyse current literature regarding influence of different dietary supplements on the course of asthma in both adults and children. Methods and Materials: Extensive research was conducted using PubMed and Google Scholar, with the primary focus on literature from the past 5 years. Firstly, potential dietary supplements affecting course of asthma were collected. The names of the substances were juxtaposed with term “Asthma” to gather data regarding their effect on occurrence and control of asthma and potential mechanisms responsible for it. Additionally, references from selected articles were included in the analysis. Results: Dietary supplements show promising results in decreasing asthma symptoms and lowering inflammation of airway. However, our study revealed that in current state of knowledge there is a deficit of studies performed on humans, especially large-scale, prospective studies that assess the efficacy of different doses of dietary supplements. Thus, further research of dietary supplements in asthma is needed, especially large-scale randomised controlled trials.

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The Effect of Vitamin D Supplementation in Children With Asthma: A Meta-Analysis

Cited by 9 publications

References 36 publications

The Impact of Vitamin D Supplementation on Asthma Control in Children

The Impact of Vitamin D Supplementation on Asthma Control in Children

Relationship between vitamin D and asthma from gestational to adulthood period: a meta-analysis of randomized clinical trials

Role of dietary supplements in the treatment of asthma - a narrative review

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