2017
DOI: 10.4103/1735-1995.200271
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The effect of Vitamin D and calcium plus Vitamin D on leg cramps in pregnant women: A randomized controlled trial

Abstract: Background:This study intended to determine the effects of Vitamin D and calcium-Vitamin D in treating leg cramps in pregnant women.Materials and Methods:This study was conducted as a double-blind randomized controlled clinical trial on 126 participants, 18–35-year-old pregnant women with a minimum of two leg cramps per week who were referred to health-care centers in Tabriz-Iran in 2013. The participants were allocated to three 42 member groups using a randomized block design. For 42 days, the intervention gr… Show more

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Cited by 20 publications
(29 citation statements)
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“…Even though LCs were common among the pregnant mothers in this study, the description of LCs in terms of its frequency, duration and severity of pain suggests that LCs might be tolerable by them. They appeared to have less frequent LCs compared to the pregnant women in two randomised control trials (Dahle et al, 1995;Mirghafourvand et al, 2017). In our study, about half of the pregnant mothers had once to twice LCs in a week.…”
Section: Figure 1: Study Low At the Health Cliniccontrasting
confidence: 41%
See 1 more Smart Citation
“…Even though LCs were common among the pregnant mothers in this study, the description of LCs in terms of its frequency, duration and severity of pain suggests that LCs might be tolerable by them. They appeared to have less frequent LCs compared to the pregnant women in two randomised control trials (Dahle et al, 1995;Mirghafourvand et al, 2017). In our study, about half of the pregnant mothers had once to twice LCs in a week.…”
Section: Figure 1: Study Low At the Health Cliniccontrasting
confidence: 41%
“…A Cochrane systematic review on interventions for LCs in pregnancy using magnesium, calcium or vitamin B12 supplements showed inconclusive evidence of their effectiveness (Zhou et al, 2015). A randomized control trial revealed that calcium with vitamin D, or vitamin D alone did not help in reducing the frequency, duration and pain intensity of LC in pregnancy (Mirghafourvand et al, 2017). Nonpharmacological treatment such as leg stretchers or massage also showed limited evidence in treating LCs.…”
Section: Introductionmentioning
confidence: 99%
“…The scale was also used in a previous study of pregnant women in Tabriz-Iran. (Mirghafourvand, Mohammad-Alizadeh-Charandabi, Mansouri, Najafi, & Khodabandeh, 2015) 2.6 | Data analysis…”
Section: Data Collection Toolsmentioning
confidence: 99%
“…The mechanism of LMCs during pregnancy is unclear (4) and their possible causes are metabolic and physiological changes during pregnancy (4,6), increased pressure on the leg muscles, pressure on the blood vessels and nerves due to uterine enlargement, imbalance between absorption and excretion of electrolytes and vitamins and the need for fetuses to absorb minerals and vitamins from their mothers (4)(5)(6)(7)(8).…”
Section: Introductionmentioning
confidence: 99%