The effect of vitamin D deficiency on eradication rates of Helicobacter pylori infection

Abstract

Background/Aim: Many studies have investigated risk factors other than antibiotic resistance linked to Helicobacter pylori (H. pylori) eradication failure. The aim of this study was to study the effect of serum levels of D) on eradication rates of H. pylori infection. Methods: This study included 150 patients diagnosed with H. pylori gastritis using magnifying narrow-band imaging endoscopy supported by stool antigen test. Serum 25-OH vitamin D levels were measured via the Enzyme-Linked Immune Sorbent assay (ELISA) method before starting eradication therapy of H. pylori infection. All patients were treated with clarithromycin-based triple therapy for 14 days. H. pylori eradication was determined via a stool antigen test performed 4 weeks after the end of therapy. According to the serum level of 25-OH vitamin D levels, the patients were divided into two groups: group I (sufficient) had a vitamin D level of ≥20 ng/mL, while group II (deficient) had a vitamin D level of <20 ng/mL. Results: Our results revealed that eradication was successful in 105 (70%) patients and failed in 45 (30%) patients. The mean 25[OH]D level was significantly lower in the eradication failure group compared to the successful treatment group (14.7 AE 4.5 vs 27.41 AE 7.1; P < 0.001). Furthermore, there were significantly more patients with deficient 25[OH]D levels in the failed treatment group, 30 (66.6%), compared to the successful group, 10 (9.5%) (P < 0.001). Conclusions: Our results demonstrated that 25-OH vitamin D deficiency may be considered a risk factor related to eradication failure of H. pylori infection. In addition, a further randomized trial to evaluate the effect of vitamin D supplementation in H. pylori eradication is mandatory.

Influence of serum vitamin D level on Helicobacter pylori eradication: A multi‐center, observational, prospective and cohort study

“…Several clinical studies have illustrated that vitamin D analogs may have anti‐ H. pylori antimicrobial effects . Some studies have also found that serum vitamin D levels may have an impact on H. pylori eradication …”

“…Vitamin D regulates the calcium and phosphorus metabolism needed for bone formation, and the influence of vitamin D on H. pylori infection and eradication rates has recently been widely investigated. Several clinical studies have illustrated that vitamin D analogs may have anti‐ H. pylori antimicrobial effects . Cytological research has also found that vitamin D 3 decomposition product 1 (VDP1) can lyse H. pylori bacterial cells by inducing the collapse of the cell membrane …”

“…Several clinical studies have illustrated that vitamin D analogs may have anti-H. pylori antimicrobial effects. [4][5][6][7][8][9][10] Cytological research has also found that vitamin D 3 decomposition product 1 (VDP1) can lyse H. pylori bacterial cells by inducing the collapse of the cell membrane. 11,12 However, the correlation between vitamin D levels and H. pylori has not been fully illustrated, and studies on the impact of serum vitamin D levels on H. pylori eradication were mostly of small sample sizes.…”

“…Another study found that the alkyl of indene, a product of vitamin D decomposition, had the key conformation of interaction with the di-14:0 DMPE in the lipid membrane component of H. pylori, which eventually induced lysis, and the absence of alkyl led to the loss of a bactericidal effect on H. pylori 12. Several clinical studies have illustrated that vitamin D analogs may have anti-H. pylori antimicrobial effects [4][5][6][7][8][9][10]. Some studies have also found that serum vitamin D levels may have an impact on H. pylori eradication [7][8][9].…”

Effect of vitamin D on Helicobacter pylori infection and eradication: A meta‐analysis

“…Our search identified 182 related references, of which 10 papers met our inclusion criteria . The flowchart describing the process of study selection is shown in Figure .…”