The Effect of Vitamin D Supplementation on Clinical Outcomes for Critically Ill Patients: A Systemic Review and Meta-Analysis of Randomized Clinical Trials

Shen, Hejuan; Mei, Yijun; Zhang, Kai; Xu, Xin

doi:10.3389/fnut.2021.664940

Cited by 15 publications

(9 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 4–7 Similarly, the rate of morbidity and mortality was considerably high in COVID positive patients having vitamin D deficiency as compared to patients with normal levels of vitamin D. 8–11 However, RCTs showing improvement in the mortality rate with vitamin D supplementation remains non-significant, majorly due to smaller sample size and lower incidence of mortality in the study participants. 12 In contrast, there was another study that documented a positive impact on mortality with vitamin D supplementation. 13 …”

Section: Introductionmentioning

confidence: 99%

Does vitamin D supplementation reduce COVID-19 severity?: a systematic review

Shah

Varna

Sharma

et al. 2022

QJM: An International Journal of Medicine

View full text Add to dashboard Cite

Background and Aim The evidence regarding the efficacy of vitamin D supplementation in reducing severity of COVID-19 is still insufficient. This is partially due to the lack of primary robust trial-based data and heterogenous study designs. This evidence summary, aims to study the effect of vitamin D supplementation on morbidity and mortality in hospitalized COVID-19 patients. Methods For this study, systematic reviews and meta-analysis published from December 2019 to January 2022 presenting the impact of vitamin D supplementation on COVID-19 severity were screened and selected from PubMed and Google scholar. After initial screening, 10 eligible reviews were identified and quality of included reviews were assessed using AMSTAR and GRADE tools and overlapping among the primary studies used were also assessed. Results The number of primary studies included in the systematic reviews ranged from 3-13. Meta-analysis of seven systematic reviews showed strong evidence that vitamin D supplementation reduces the risk of mortality (Odds ratio: 0.48, 95% CI: 0.346-0.664; p < 0.001) in COVID patients. It was also observed that supplementation reduces the need for intensive care (Odds ratio: 0.35; 95%CI: 0.28-0.44; p < 0.001) and mechanical ventilation (Odds ratio: 0.54; 95% CI: 0.411-0.708; p < 0.001) requirement. The findings were robust and reliable as level of heterogeneity was considerably low. Qualitative analysis showed that supplements (oral and IV) are well tolerated, safe and effective in COVID patients. Conclusion Findings of this study shows that vitamin D supplementation is effective in reducing COVID-19 severity. Hence vitamin D should be recommended as an adjuvant therapy for COVID-19.

show abstract

Section: Introductionmentioning

confidence: 99%

Does vitamin D supplementation reduce COVID-19 severity?: a systematic review

Shah

Varna

Sharma

et al. 2022

QJM: An International Journal of Medicine

View full text Add to dashboard Cite

show abstract

“…As a result, vitamin D deficiency could increase the risk of sepsis and inflammation in severely ill patients by diminishing the immune response and modulatory effects on innate immunity. [67][68][69][70][71][72] The strength of this study lies in the fact that it is the first study to analyze the ISARIC-4C Score in COVID-19 patients with deficient vitamin D. The majority of this study's data were collected during the Omicron variation's development and can be utilized to make comparisons to the Delta variant or any other variants. However, this study has several limitations that should be considered to improve the further research.…”

Section: Discussionmentioning

confidence: 99%

Impact of vitamin D deficiency in relation to the clinical outcomes of hospitalized COVID-19 patients

Rachman

Rahmaniyah²,

Khomeini³

et al. 2023

F1000Res

View full text Add to dashboard Cite

Background: Vitamin D deficiency is an emerging public health problem that affects more than one billion people worldwide. Vitamin D has been shown to be effective in preventing and reducing the severity of viral respiratory diseases, including influenza. However, the role of vitamin D in COVID-19 infection remains controversial. This study aimed to analyze the impact of vitamin D deficiency on the clinical outcome of hospitalized COVID-19 patients. Methods: A prospective cohort study was conducted among hospitalized COVID-19 patients at two COVID-19 referral hospitals in Indonesia from October 2021 until February 2022. Results: The median serum 25(OH)D level in 191 hospitalized COVID-19 patients was 13.6 [IQR=10.98] ng/mL. The serum 25(OH)D levels were significantly lower among COVID-19 patients with vitamin D deficiency who had cardiovascular disease (p-value=0.04), the use of a ventilator (p-value=0.004), more severe COVID-19 cases (p-value=0.047), and mortality (p-value=0.002). Furthermore, serum 25(OH)D levels were significantly different between patients with mild and severe COVID-19 cases (p-value=0.019). Serum 25(OH)D levels in moderate and severe COVID-19 cases were significantly different (p-value=0.031). Lower serum 25(OH)D levels were significantly associated with an increased number of comorbidities (p-value=0.03), the severity of COVID-19 (p-value=0.002), and the use of mechanical ventilation (p-value=0.032). Mortality was found in 7.3% of patients with deficient vitamin D levels. However, patients with either sufficient or insufficient vitamin D levels did not develop mortality. Conclusions: COVID-19 patients with vitamin D deficiency were significantly associated with having cardiovascular disease, mortality, more severe COVID-19 cases, and the used of mechanical ventilation. Lower serum 25(OH)D levels were associated with an increased number of comorbidities, COVID-19 severity, and the use of mechanical-ventilation. Thus, we suggest hospitalized COVID-19 patients to reach a sufficient vitamin D status to improve the clinical outcome of the disease.

show abstract

“…As a result, vitamin D deficiency could increase the risk of sepsis and inflammation in severely ill patients by diminishing the immune response and modulatory effects on innate immunity. [78][79][80][81][82][83] Furthermore, several COVID-19 pandemic studies contained some substantial biases and were not representative of the real-world conditions of the COVID-19 pandemic. 84,85 In regions where authorities implemented home isolation and social distancing measures, individuals with mild to moderate cases of COVID-19 were generally not hospitalized.…”

Section: Discussionmentioning

confidence: 99%

Impact of vitamin D deficiency in relation to the clinical outcomes of hospitalized COVID-19 patients

et al. 2023

View full text Add to dashboard Cite

Background: Vitamin D deficiency is an emerging public health problem that affects more than one billion people worldwide. Vitamin D has been shown to be effective in preventing and reducing the severity of viral respiratory diseases, including influenza. However, the role of vitamin D in COVID-19 infection remains controversial. This study aimed to analyze the impact of vitamin D deficiency on the clinical outcome of hospitalized COVID-19 patients. Methods: A prospective cohort study was conducted among hospitalized COVID-19 patients at two COVID-19 referral hospitals in Indonesia from October 2021 until February 2022. Results: The median serum 25(OH)D level in 191 hospitalized COVID-19 patients was 13.6 [IQR=10.98] ng/mL. The serum 25(OH)D levels were significantly lower among COVID-19 patients with vitamin D deficiency who had cardiovascular disease (p-value=0.04), the use of a ventilator (p-value=0.004), more severe COVID-19 cases (p-value=0.047), and mortality (p-value=0.002). Furthermore, serum 25(OH)D levels were significantly different between patients with mild and severe COVID-19 cases (p-value <0.001). Serum 25(OH)D levels in mild and moderate COVID-19 cases were significantly different (p-value=0.002). Lower serum 25(OH)D levels were significantly associated with an increased number of comorbidities (p-value=0.03), the severity of COVID-19 (p-value=0.002), and the use of mechanical ventilation (p-value=0.032). Mortality was found in 7.3% of patients with deficient vitamin D levels. However, patients with either sufficient or insufficient vitamin D levels did not develop mortality. Conclusions: COVID-19 patients with vitamin D deficiency were significantly associated with having cardiovascular disease, mortality, more severe COVID-19 cases, and the used of mechanical ventilation. Lower serum 25(OH)D levels were associated with an increased number of comorbidities, COVID-19 severity, and the use of mechanical-ventilation. Thus, we suggest hospitalized COVID-19 patients to reach a sufficient vitamin D status to improve the clinical outcome of the disease.

show abstract

The Effect of Vitamin D Supplementation on Clinical Outcomes for Critically Ill Patients: A Systemic Review and Meta-Analysis of Randomized Clinical Trials

Cited by 15 publications

References 44 publications

Does vitamin D supplementation reduce COVID-19 severity?: a systematic review

Does vitamin D supplementation reduce COVID-19 severity?: a systematic review

Impact of vitamin D deficiency in relation to the clinical outcomes of hospitalized COVID-19 patients

Impact of vitamin D deficiency in relation to the clinical outcomes of hospitalized COVID-19 patients

Contact Info

Product

Resources

About